Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress

Expression of HMGCS2 in intestinal epithelial cells is downregulated in inflammatory bowel disease associated with endoplasmic reticulum stress

IntroductionThe Unfolded Protein Response, a mechanism triggered by the cell in response to Endoplasmic reticulum stress, is linked to inflammatory responses. Our aim was to identify novel Unfolded Protein Response-mechanisms that might be involved in triggering or perpetuating the inflammatory resp...

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Main Authors:	Beatriz Martín-Adrados, Stefanie K. Wculek, Sergio Fernández-Bravo, Raúl Torres-Ruiz, Ana Valle-Noguera, Maria José Gomez-Sánchez, José Carlos Hernández-Walias, Frederico Moraes Ferreira, Ana María Corraliza, David Sancho, Vanesa Esteban, Sandra Rodriguez-Perales, Aránzazu Cruz-Adalia, Helder I. Nakaya, Azucena Salas, David Bernardo, Yolanda Campos-Martín, Elena Martínez-Zamorano, Diego Muñoz-López, Manuel Gómez del Moral, Francisco Javier Cubero, Richard S. Blumberg, Eduardo Martínez-Naves
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Series:	Frontiers in Immunology
Subjects:	inflammatory bowel disease inflammation ER stress HMGCS2 unfolded protein response (UPR)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185517/full

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