Opioids in chronic non cancer pain: rational and selection criteria
The therapeutic efficacy and appearance of side effects of opioid drugs is strongly conditioned by the patient’s individual characteristics. It is impossible to know the patient’s particular pharmacogenomic connotations which determine those phenotypic expressions that make the patient more or less...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Publiediting
2011-03-01
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| Series: | Pathos |
| Subjects: | |
| Online Access: | http://www.pathos-journal.com/doc/Uso_degli_oppiacei_nel_dolore_cronico.pdf |
| _version_ | 1818885796718968832 |
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| author | S. Mameli A. Pili G. M. Pisanu M. Carboni E. Marchi |
| author_facet | S. Mameli A. Pili G. M. Pisanu M. Carboni E. Marchi |
| author_sort | S. Mameli |
| collection | DOAJ |
| description | The therapeutic efficacy and appearance of side effects of opioid drugs is strongly conditioned by the patient’s individual characteristics. It is impossible to know the patient’s particular pharmacogenomic connotations which determine those phenotypic expressions that make the patient more or less sensitive to the administered drug, and that also determine the presence and signifi cance of side effects. Knowledge of the patient’s hepatic opioid metabolization can aid in the choice of a more personalised therapy. To reduce the unpredictability of favourable effects and side effects, it is preferable to choose drugs that are less affected by pharmacological interactions, and that can also compromise the efficacy of the many pharmacological associations that patients undergo, especially elderly patients, who often suffer from serious organ impairments. |
| first_indexed | 2024-12-19T16:11:08Z |
| format | Article |
| id | doaj.art-59e0436d21494a7a8499235763986eaa |
| institution | Directory Open Access Journal |
| issn | 1593-2354 |
| language | English |
| last_indexed | 2024-12-19T16:11:08Z |
| publishDate | 2011-03-01 |
| publisher | Publiediting |
| record_format | Article |
| series | Pathos |
| spelling | doaj.art-59e0436d21494a7a8499235763986eaa2022-12-21T20:14:44ZengPublieditingPathos1593-23542011-03-011811525Opioids in chronic non cancer pain: rational and selection criteriaS. MameliA. PiliG. M. PisanuM. CarboniE. MarchiThe therapeutic efficacy and appearance of side effects of opioid drugs is strongly conditioned by the patient’s individual characteristics. It is impossible to know the patient’s particular pharmacogenomic connotations which determine those phenotypic expressions that make the patient more or less sensitive to the administered drug, and that also determine the presence and signifi cance of side effects. Knowledge of the patient’s hepatic opioid metabolization can aid in the choice of a more personalised therapy. To reduce the unpredictability of favourable effects and side effects, it is preferable to choose drugs that are less affected by pharmacological interactions, and that can also compromise the efficacy of the many pharmacological associations that patients undergo, especially elderly patients, who often suffer from serious organ impairments.http://www.pathos-journal.com/doc/Uso_degli_oppiacei_nel_dolore_cronico.pdfChronic nonmalignant painHepatic opioid metabolizationPharmacological interactions |
| spellingShingle | S. Mameli A. Pili G. M. Pisanu M. Carboni E. Marchi Opioids in chronic non cancer pain: rational and selection criteria Pathos Chronic nonmalignant pain Hepatic opioid metabolization Pharmacological interactions |
| title | Opioids in chronic non cancer pain: rational and selection criteria |
| title_full | Opioids in chronic non cancer pain: rational and selection criteria |
| title_fullStr | Opioids in chronic non cancer pain: rational and selection criteria |
| title_full_unstemmed | Opioids in chronic non cancer pain: rational and selection criteria |
| title_short | Opioids in chronic non cancer pain: rational and selection criteria |
| title_sort | opioids in chronic non cancer pain rational and selection criteria |
| topic | Chronic nonmalignant pain Hepatic opioid metabolization Pharmacological interactions |
| url | http://www.pathos-journal.com/doc/Uso_degli_oppiacei_nel_dolore_cronico.pdf |
| work_keys_str_mv | AT smameli opioidsinchronicnoncancerpainrationalandselectioncriteria AT apili opioidsinchronicnoncancerpainrationalandselectioncriteria AT gmpisanu opioidsinchronicnoncancerpainrationalandselectioncriteria AT mcarboni opioidsinchronicnoncancerpainrationalandselectioncriteria AT emarchi opioidsinchronicnoncancerpainrationalandselectioncriteria |