Alkyl polyglucoside-stabilized emulsion as a prospective vehicle for Usnea barbata CO2-supercritical extract: Assessing stability, safety and efficiency of a topical formulation
Antimicrobial activity of Usnea barbata especially against bacteria involved in pathogenesis of various skin conditions has been well documented in literature. Nevertheless, there are no papers dealing with formulation of its isolates into topical preparations for treatment of skin infectio...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Association of Chemical Engineers of Serbia
2015-01-01
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| Series: | Hemijska Industrija |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0367-598X/2015/0367-598X1500002Z.pdf |
| Summary: | Antimicrobial activity of Usnea barbata especially against bacteria involved
in pathogenesis of various skin conditions has been well documented in
literature. Nevertheless, there are no papers dealing with formulation of its
isolates into topical preparations for treatment of skin infections. In
present study, alkyl polyglucoside (APG) - based vehicle was developed as
carrier of U. barbata CO2-supercritical extract (U-SE) that demonstrated the
best antimicrobial potential in preliminary screening. For comparison, chosen
extract in the same concentration and using the same procedure was
incorporated into a pharmacopoeial vehicle. Comparative evaluation of
physicochemical stability, efficiency and safety proved APG-based vehicle to
possess certain preferential features as carrier of U-SE compared to the
reference one, composing a topical formulation with potential clinical
relevance in treatment of skin infections. [Projekat Ministarstva nauke
Republike Srbije, br. III45017 i br. TR34031] |
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| ISSN: | 0367-598X 2217-7426 |