The Role of DNA Methylation in Stroke Recovery
Epigenetic alterations affect the onset of ischemic stroke, brain injury after stroke, and mechanisms of poststroke recovery. In particular, DNA methylation can be dynamically altered by maintaining normal brain function or inducing abnormal brain damage. DNA methylation is regulated by DNA methyltr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/18/10373 |
| _version_ | 1797487440243458048 |
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| author | Dong-Hee Choi In-Ae Choi Jongmin Lee |
| author_facet | Dong-Hee Choi In-Ae Choi Jongmin Lee |
| author_sort | Dong-Hee Choi |
| collection | DOAJ |
| description | Epigenetic alterations affect the onset of ischemic stroke, brain injury after stroke, and mechanisms of poststroke recovery. In particular, DNA methylation can be dynamically altered by maintaining normal brain function or inducing abnormal brain damage. DNA methylation is regulated by DNA methyltransferase (DNMT), which promotes methylation, DNA demethylase, which removes methyl groups, and methyl-cytosine–phosphate–guanine-binding domain (MBD) protein, which binds methylated DNA and inhibits gene expression. Investigating the effects of modulating DNMT, TET, and MBD protein expression on neuronal cell death and neurorepair in ischemic stroke and elucidating the underlying mechanisms can facilitate the formulation of therapeutic strategies for neuroprotection and promotion of neuronal recovery after stroke. In this review, we summarize the role of DNA methylation in neuroprotection and neuronal recovery after stroke according to the current knowledge regarding the effects of DNA methylation on excitotoxicity, oxidative stress, apoptosis, neuroinflammation, and recovery after ischemic stroke. This review of the literature regarding the role of DNA methylation in neuroprotection and functional recovery after stroke may contribute to the development and application of novel therapeutic strategies for stroke. |
| first_indexed | 2024-03-09T23:47:39Z |
| format | Article |
| id | doaj.art-59e1b380ae5446a48019acf5743721da |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:47:39Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-59e1b380ae5446a48019acf5743721da2023-11-23T16:40:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123181037310.3390/ijms231810373The Role of DNA Methylation in Stroke RecoveryDong-Hee Choi0In-Ae Choi1Jongmin Lee2Center for Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University, Seoul 05029, KoreaCenter for Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University, Seoul 05029, KoreaCenter for Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University, Seoul 05029, KoreaEpigenetic alterations affect the onset of ischemic stroke, brain injury after stroke, and mechanisms of poststroke recovery. In particular, DNA methylation can be dynamically altered by maintaining normal brain function or inducing abnormal brain damage. DNA methylation is regulated by DNA methyltransferase (DNMT), which promotes methylation, DNA demethylase, which removes methyl groups, and methyl-cytosine–phosphate–guanine-binding domain (MBD) protein, which binds methylated DNA and inhibits gene expression. Investigating the effects of modulating DNMT, TET, and MBD protein expression on neuronal cell death and neurorepair in ischemic stroke and elucidating the underlying mechanisms can facilitate the formulation of therapeutic strategies for neuroprotection and promotion of neuronal recovery after stroke. In this review, we summarize the role of DNA methylation in neuroprotection and neuronal recovery after stroke according to the current knowledge regarding the effects of DNA methylation on excitotoxicity, oxidative stress, apoptosis, neuroinflammation, and recovery after ischemic stroke. This review of the literature regarding the role of DNA methylation in neuroprotection and functional recovery after stroke may contribute to the development and application of novel therapeutic strategies for stroke.https://www.mdpi.com/1422-0067/23/18/10373stroketreatmentrecoveryepigeneticsDNA methylationneuroprotection |
| spellingShingle | Dong-Hee Choi In-Ae Choi Jongmin Lee The Role of DNA Methylation in Stroke Recovery International Journal of Molecular Sciences stroke treatment recovery epigenetics DNA methylation neuroprotection |
| title | The Role of DNA Methylation in Stroke Recovery |
| title_full | The Role of DNA Methylation in Stroke Recovery |
| title_fullStr | The Role of DNA Methylation in Stroke Recovery |
| title_full_unstemmed | The Role of DNA Methylation in Stroke Recovery |
| title_short | The Role of DNA Methylation in Stroke Recovery |
| title_sort | role of dna methylation in stroke recovery |
| topic | stroke treatment recovery epigenetics DNA methylation neuroprotection |
| url | https://www.mdpi.com/1422-0067/23/18/10373 |
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