Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma

Ubiquitous Aberration in Cholesterol Metabolism across Pancreatic Ductal Adenocarcinoma

Pancreatic cancer (PC) is characterized by metabolic deregulations that often manifest as deviations in metabolite levels and aberrations in their corresponding metabolic genes across the clinical specimens and preclinical PC models. Cholesterol is one of the critical metabolites supporting PC, synt...

Full description

Bibliographic Details
Main Authors:	Venugopal Gunda, Thiago C. Genaro-Mattos, Jyoti B. Kaushal, Ramakanth Chirravuri-Venkata, Gopalakrishnan Natarajan, Kavita Mallya, Paul M. Grandgenett, Karoly Mirnics, Surinder K. Batra, Zeljka Korade, Satyanarayana Rachagani
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Series:	Metabolites
Subjects:	PDAC (pancreatic ductal adenocarcinoma) free cholesterol Dhcr24 Dhcr7 sterol analysis
Online Access:	https://www.mdpi.com/2218-1989/12/1/47

Similar Items

Chemical Inhibition of Sterol Biosynthesis
by: Eric S. Peeples, et al.
Published: (2024-03-01)

Phytophthora capsici sterol reductase PcDHCR7 has a role in mycelium development and pathogenicity
by: Weizhen Wang, et al.
Published: (2022-04-01)

Chronic Aripiprazole and Trazodone Polypharmacy Effects on Systemic and Brain Cholesterol Biosynthesis
by: Zeljka Korade, et al.
Published: (2023-08-01)

TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia
by: Zhao Li, et al.
Published: (2024-04-01)

Metoprolol Inhibits Developmental Brain Sterol Biosynthesis in Mice
by: Luke B. Allen, et al.
Published: (2022-08-01)

Generation and validation of a conditional knockout mouse model for desmosterolosis
by: Babunageswararao Kanuri, et al.
Published: (2021-01-01)

Cholic acid increases plasma cholesterol in Smith-Lemli-Opitz syndrome: A pilot study
by: Ellen R. Elias, et al.
Published: (2024-03-01)

Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer
by: Yuqi Chen, et al.
Published: (2023-01-01)

Identification and Characterization of 24-Dehydrocholesterol Reductase (DHCR24) in the Two-Spotted Cricket, <i>Gryllus bimaculatus</i>
by: Yin Shan Isa Mack, et al.
Published: (2021-09-01)

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death
by: Henna Martiskainen, et al.
Published: (2017-11-01)

Elevated autophagy and mitochondrial dysfunction in the Smith–Lemli–Opitz Syndrome
by: Shaohua Chang, et al.
Published: (2014-01-01)

Effect of DHCR7 on adipocyte differentiation in goats
by: Zhibin Li, et al.
Published: (2024-12-01)

Cellular cholesterol loss by DHCR24 knockdown leads to Aβ production by changing APP intracellular localization
by: Yue Huang, et al.
Published: (2023-05-01)

Identification of genes involved in chicken follicle selection by ONT sequencing on granulosa cells
by: Dandan Li, et al.
Published: (2023-01-01)

DBP rs7041 and DHCR7 rs3829251 are Linked to CD4+ Recovery in HIV Patients on Antiretroviral Therapy
by: Salvador Resino, et al.
Published: (2022-01-01)

The role of DHCR24 in the pathogenesis of AD: re-cognition of the relationship between cholesterol and AD pathogenesis
by: Xiaojing Bai, et al.
Published: (2022-03-01)

Familial DHCR7 genotype presenting as a very mild form of Smith‐Lemli‐Opitz syndrome and lethal holoprosencephaly
by: Suzanna E. L. Temple, et al.
Published: (2020-11-01)

Sterol dysregulation in Smith–Lemli–Opitz syndrome causes astrocyte immune reactivity through microglia crosstalk
by: Bethany A. Freel, et al.
Published: (2022-12-01)

Metabolic engineering of Saccharomyces cerevisiae for 7-dehydrocholesterol overproduction
by: Xiao-Jing Guo, et al.
Published: (2018-07-01)

LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway
by: Ziye Chen, et al.
Published: (2021-09-01)

DPP4 Regulates DHCR24-Mediated Cholesterol Biosynthesis to Promote Methotrexate Resistance in Gestational Trophoblastic Neoplastic Cells
by: Weijie Yuan, et al.
Published: (2021-12-01)

Exploiting in silico structural analysis to introduce emerging genotype–phenotype correlations in DHCR24-related sterol biosynthesis disorder: a case study
by: Dario Cocciadiferro, et al.
Published: (2024-01-01)

Association of Vitamin D Anabolism-Related Gene Polymorphisms and Susceptibility to Uterine Leiomyomas
by: Shangdan Xie, et al.
Published: (2022-06-01)

Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity
by: Nikola Kotur, et al.
Published: (2021-06-01)

Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model
by: Kavita Mallya, et al.
Published: (2020-09-01)

Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway
by: Atikam Qurban, et al.
Published: (2025-01-01)

A study on the functional role of the DHCR24 gene in gonadal differentiation and development of Macrobrachium nipponense
by: Pengfei Cai, et al.
Published: (2024-11-01)

The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children
by: Yuling Zhang, et al.
Published: (2012-07-01)

DHCR24 reverses Alzheimer’s disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice
by: Wen-bin Zhang, et al.
Published: (2023-06-01)

Virtual Screening of Novel 24-Dehydroxysterol Reductase (<i>DHCR24</i>) Inhibitors and the Biological Evaluation of Irbesartan in Cholesterol-Lowering Effect
by: Haozhen Wang, et al.
Published: (2023-03-01)

Combination treatment of docetaxel with caffeic acid phenethyl ester suppresses the survival and the proliferation of docetaxel-resistant prostate cancer cells via induction of apoptosis and metabolism interference
by: Yu-Ke Fu, et al.
Published: (2022-02-01)

DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3β/mTOR Signaling
by: Xiaojing Bai, et al.
Published: (2021-04-01)

Smith-Lemli-Opitz syndrome: Bosnian and Herzegovinian experience
by: Begic N, et al.
Published: (2021-07-01)

The genetic determinants of circulating C3-epimers of 25-hydroxyvitamin D
by: Sirikunya Torugsa, et al.
Published: (2018-06-01)

Biochemical and physiological improvement in a mouse model of Smith–Lemli–Opitz syndrome (SLOS) following gene transfer with AAV vectors
by: Lee Ying, et al.
Published: (2014-01-01)

Microbiome in pancreatic cancer – What is new in 2024?
by: E. Hohmann, et al.
Published: (2024-10-01)

Targeted Therapies in Pancreatic Cancer: A New Era of Precision Medicine
by: Bingyu Li, et al.
Published: (2024-09-01)

Oral mycobiota and pancreatic ductal adenocarcinoma
by: Ailin Wei, et al.
Published: (2022-12-01)

Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers
by: Nagabhishek Sirpu Natesh, et al.
Published: (2021-11-01)

Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling
by: Parthasarathy Seshacharyulu, et al.
Published: (2022-01-01)