Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis.
BACKGROUND: Previous studies have yielded conflicting results regarding the relationship between p53 status and response to chemotherapy in patients with gastric cancer. We therefore performed a meta-analysis to expound the relationship between p53 status and response to chemotherapy. METHODS/FINDIN...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3989310?pdf=render |
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| author | Hai-Yuan Xu Wen-Lin Xu Li-Qiang Wang Min-Bin Chen Hui-Ling Shen |
| author_facet | Hai-Yuan Xu Wen-Lin Xu Li-Qiang Wang Min-Bin Chen Hui-Ling Shen |
| author_sort | Hai-Yuan Xu |
| collection | DOAJ |
| description | BACKGROUND: Previous studies have yielded conflicting results regarding the relationship between p53 status and response to chemotherapy in patients with gastric cancer. We therefore performed a meta-analysis to expound the relationship between p53 status and response to chemotherapy. METHODS/FINDINGS: Thirteen previously published eligible studies, including 564 cases, were identified and included in this meta-analysis. p53 positive status (high expression of p53 protein and/or a mutant p53 gene) was associated with improved response in gastric cancer patients who received chemotherapy (good response: risk ratio [RR] = 0.704; 95% confidence intervals [CI] = 0.550-0.903; P = 0.006). In further stratified analyses, association with a good response remained in the East Asian population (RR = 0.657; 95% CI = 0.488-0.884; P = 0.005), while in the European subgroup, patients with p53 positive status tended to have a good response to chemotherapy, although this did not reach statistical significance (RR = 0.828, 95% CI = 0.525-1.305; P = 0.417). As five studies used neoadjuvant chemotherapy (NCT) and one used neoadjuvant chemoradiotherapy (NCRT), we also analyzed these data, and found that p53 positive status was associated with a good response in gastric cancer patients who received chemotherapy-based neoadjuvant treatment (RR = 0.675, 95% CI = 0.463-0.985; P = 0.042). CONCLUSION: This meta-analysis indicated that p53 status may be a useful predictive biomarker for response to chemotherapy in gastric cancer. Further prospective studies with larger sample sizes and better study designs are required to confirm our findings. |
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| id | doaj.art-59e3b562bb1b42b0af1bd723065a989d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T18:24:22Z |
| publishDate | 2014-01-01 |
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| series | PLoS ONE |
| spelling | doaj.art-59e3b562bb1b42b0af1bd723065a989d2022-12-22T03:21:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9537110.1371/journal.pone.0095371Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis.Hai-Yuan XuWen-Lin XuLi-Qiang WangMin-Bin ChenHui-Ling ShenBACKGROUND: Previous studies have yielded conflicting results regarding the relationship between p53 status and response to chemotherapy in patients with gastric cancer. We therefore performed a meta-analysis to expound the relationship between p53 status and response to chemotherapy. METHODS/FINDINGS: Thirteen previously published eligible studies, including 564 cases, were identified and included in this meta-analysis. p53 positive status (high expression of p53 protein and/or a mutant p53 gene) was associated with improved response in gastric cancer patients who received chemotherapy (good response: risk ratio [RR] = 0.704; 95% confidence intervals [CI] = 0.550-0.903; P = 0.006). In further stratified analyses, association with a good response remained in the East Asian population (RR = 0.657; 95% CI = 0.488-0.884; P = 0.005), while in the European subgroup, patients with p53 positive status tended to have a good response to chemotherapy, although this did not reach statistical significance (RR = 0.828, 95% CI = 0.525-1.305; P = 0.417). As five studies used neoadjuvant chemotherapy (NCT) and one used neoadjuvant chemoradiotherapy (NCRT), we also analyzed these data, and found that p53 positive status was associated with a good response in gastric cancer patients who received chemotherapy-based neoadjuvant treatment (RR = 0.675, 95% CI = 0.463-0.985; P = 0.042). CONCLUSION: This meta-analysis indicated that p53 status may be a useful predictive biomarker for response to chemotherapy in gastric cancer. Further prospective studies with larger sample sizes and better study designs are required to confirm our findings.http://europepmc.org/articles/PMC3989310?pdf=render |
| spellingShingle | Hai-Yuan Xu Wen-Lin Xu Li-Qiang Wang Min-Bin Chen Hui-Ling Shen Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis. PLoS ONE |
| title | Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis. |
| title_full | Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis. |
| title_fullStr | Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis. |
| title_full_unstemmed | Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis. |
| title_short | Relationship between p53 status and response to chemotherapy in patients with gastric cancer: a meta-analysis. |
| title_sort | relationship between p53 status and response to chemotherapy in patients with gastric cancer a meta analysis |
| url | http://europepmc.org/articles/PMC3989310?pdf=render |
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