Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage
Abstract Background Inflammatory mechanism has been implicated in delayed cerebral ischemia (DCI) and poor functional outcomes after subarachnoid hemorrhage (SAH). Identification of cytokine patterns associated with inflammation in acute SAH will provide insights into underlying biological processes...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12974-019-1578-1 |
| _version_ | 1818188567160029184 |
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| author | Sung-Ho Ahn Jude P. J. Savarraj Kaushik Parsha Georgene W. Hergenroeder Tiffany R. Chang Dong H. Kim Ryan S. Kitagawa Spiros L. Blackburn H. Alex Choi |
| author_facet | Sung-Ho Ahn Jude P. J. Savarraj Kaushik Parsha Georgene W. Hergenroeder Tiffany R. Chang Dong H. Kim Ryan S. Kitagawa Spiros L. Blackburn H. Alex Choi |
| author_sort | Sung-Ho Ahn |
| collection | DOAJ |
| description | Abstract Background Inflammatory mechanism has been implicated in delayed cerebral ischemia (DCI) and poor functional outcomes after subarachnoid hemorrhage (SAH). Identification of cytokine patterns associated with inflammation in acute SAH will provide insights into underlying biological processes of DCI and poor outcomes that may be amenable to interventions. Methods Serum samples were collected from a prospective cohort of 60 patients with acute non-traumatic SAH at four time periods (< 24 h, 24–48 h, 3–5 days, and 6–8 days after SAH) and concentration levels of 41 cytokines were measured by multiplex immunoassay. Logistic regression analysis was used to identify cytokines associated with DCI and poor functional outcomes. Correlation networks were constructed to identify cytokine clusters. Results Of the 60 patients enrolled in the study, 14 (23.3%) developed DCI and 16 (26.7%) had poor functional outcomes at 3 months. DCI was associated with increased levels of PDGF-ABBB and CCL5 and decreased levels of IP-10 and MIP-1α. Poor functional outcome was associated with increased levels of IL-6 and MCP-1α. Network analysis identified distinct cytokine clusters associated with DCI and functional outcomes. Conclusions Serum cytokine patterns in early SAH are associated with poor functional outcomes and DCI. The significant cytokines primarily modulate the inflammatory response. This supports earlier SAH studies linking inflammation and poor outcomes. In particular, this study identifies novel cytokine patterns over time that may indicate impending DCI. |
| first_indexed | 2024-12-11T23:28:58Z |
| format | Article |
| id | doaj.art-59e4b9dbe770446a9906d5b0270f26ce |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-12-11T23:28:58Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-59e4b9dbe770446a9906d5b0270f26ce2022-12-22T00:46:05ZengBMCJournal of Neuroinflammation1742-20942019-11-0116111010.1186/s12974-019-1578-1Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhageSung-Ho Ahn0Jude P. J. Savarraj1Kaushik Parsha2Georgene W. Hergenroeder3Tiffany R. Chang4Dong H. Kim5Ryan S. Kitagawa6Spiros L. Blackburn7H. Alex Choi8Department of Neurology, Pusan National University School of Medicine, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan HospitalDepartment of Neurosurgery, University of Texas Health Science Center at HoustonDepartment of Neurology, University of Texas Health Science Center at HoustonDepartment of Neurosurgery, University of Texas Health Science Center at HoustonDepartment of Neurosurgery, University of Texas Health Science Center at HoustonDepartment of Neurosurgery, University of Texas Health Science Center at HoustonDepartment of Neurosurgery, University of Texas Health Science Center at HoustonDepartment of Neurosurgery, University of Texas Health Science Center at HoustonDepartment of Neurosurgery, University of Texas Health Science Center at HoustonAbstract Background Inflammatory mechanism has been implicated in delayed cerebral ischemia (DCI) and poor functional outcomes after subarachnoid hemorrhage (SAH). Identification of cytokine patterns associated with inflammation in acute SAH will provide insights into underlying biological processes of DCI and poor outcomes that may be amenable to interventions. Methods Serum samples were collected from a prospective cohort of 60 patients with acute non-traumatic SAH at four time periods (< 24 h, 24–48 h, 3–5 days, and 6–8 days after SAH) and concentration levels of 41 cytokines were measured by multiplex immunoassay. Logistic regression analysis was used to identify cytokines associated with DCI and poor functional outcomes. Correlation networks were constructed to identify cytokine clusters. Results Of the 60 patients enrolled in the study, 14 (23.3%) developed DCI and 16 (26.7%) had poor functional outcomes at 3 months. DCI was associated with increased levels of PDGF-ABBB and CCL5 and decreased levels of IP-10 and MIP-1α. Poor functional outcome was associated with increased levels of IL-6 and MCP-1α. Network analysis identified distinct cytokine clusters associated with DCI and functional outcomes. Conclusions Serum cytokine patterns in early SAH are associated with poor functional outcomes and DCI. The significant cytokines primarily modulate the inflammatory response. This supports earlier SAH studies linking inflammation and poor outcomes. In particular, this study identifies novel cytokine patterns over time that may indicate impending DCI.http://link.springer.com/article/10.1186/s12974-019-1578-1Subarachnoid hemorrhageDelayed cerebral ischemiaFunctional outcomeInflammationCytokine network |
| spellingShingle | Sung-Ho Ahn Jude P. J. Savarraj Kaushik Parsha Georgene W. Hergenroeder Tiffany R. Chang Dong H. Kim Ryan S. Kitagawa Spiros L. Blackburn H. Alex Choi Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage Journal of Neuroinflammation Subarachnoid hemorrhage Delayed cerebral ischemia Functional outcome Inflammation Cytokine network |
| title | Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage |
| title_full | Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage |
| title_fullStr | Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage |
| title_full_unstemmed | Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage |
| title_short | Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage |
| title_sort | inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage |
| topic | Subarachnoid hemorrhage Delayed cerebral ischemia Functional outcome Inflammation Cytokine network |
| url | http://link.springer.com/article/10.1186/s12974-019-1578-1 |
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