Comparison of the Mean Level of C3 & C4 Complements in Pre-eclamptic Patients and Normal Pregnancy
Background: Hypertension is still an important cause of mortality in mother, fetus and neonate. Up to 25% of perinatal mortality in developing countries is due to hypertension. The role of immunologic factors in development of pre-eclampsia is increasing. Decreased level of C3 & C4 complements...
| Main Authors: | , |
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| Format: | Article |
| Language: | fas |
| Published: |
Isfahan University of Medical Sciences
2007-08-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/34 |
| _version_ | 1797716517878497280 |
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| author | Shahnaz Aram Ali Shahbazi |
| author_facet | Shahnaz Aram Ali Shahbazi |
| author_sort | Shahnaz Aram |
| collection | DOAJ |
| description | Background:
Hypertension is still an important cause of mortality in mother, fetus and neonate. Up to 25% of perinatal mortality in developing countries is due to hypertension. The role of immunologic factors in development of pre-eclampsia is increasing. Decreased level of C3 & C4 complements in pre-eclamptic patients has been documented in some studies. The goal of this study is to compare the level of C3 & C4 in patients with normal pregnancy versus those with pre-eclampsia.
Methods:
This cross-sectional study was performed during one year, among pregnant women with a gestational age of more than 20 weeks and blood pressure over 140/90 mmHg plus proteinuria over 300 mg in 24h-urine or over 30 mg/dl in random urine. We selected 23 pre-eclamptic cases and 34 controls.
Findings:
Mean level of C3 in pre-eclamptic patients was 98.8±25.82 mg/dl and 112.5±29.03 mg/dl in controls (p<0.005). Mean level of C4 in pre-eclamptic patients was 27.9±10.62 mg/dl and 35±11.25 mg/dl in controls (p<0.05).
Conclusion:
In this study, the level of C3 & C4 in pre-eclamptic patients was lower than in those without pre-eclamsia. It is suggested that decreased level of these complements can be considered as a predictive factor of pre-eclampsia. More studies are warranted in this field.
Key words:
Preeclampsia, complement (C3 & C4), pregnancy |
| first_indexed | 2024-03-12T08:22:36Z |
| format | Article |
| id | doaj.art-59e542802cd042f9911d39ba93e24c9a |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:22:36Z |
| publishDate | 2007-08-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-59e542802cd042f9911d39ba93e24c9a2023-09-02T18:20:31ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2007-08-012483373333Comparison of the Mean Level of C3 & C4 Complements in Pre-eclamptic Patients and Normal PregnancyShahnaz AramAli ShahbaziBackground: Hypertension is still an important cause of mortality in mother, fetus and neonate. Up to 25% of perinatal mortality in developing countries is due to hypertension. The role of immunologic factors in development of pre-eclampsia is increasing. Decreased level of C3 & C4 complements in pre-eclamptic patients has been documented in some studies. The goal of this study is to compare the level of C3 & C4 in patients with normal pregnancy versus those with pre-eclampsia. Methods: This cross-sectional study was performed during one year, among pregnant women with a gestational age of more than 20 weeks and blood pressure over 140/90 mmHg plus proteinuria over 300 mg in 24h-urine or over 30 mg/dl in random urine. We selected 23 pre-eclamptic cases and 34 controls. Findings: Mean level of C3 in pre-eclamptic patients was 98.8±25.82 mg/dl and 112.5±29.03 mg/dl in controls (p<0.005). Mean level of C4 in pre-eclamptic patients was 27.9±10.62 mg/dl and 35±11.25 mg/dl in controls (p<0.05). Conclusion: In this study, the level of C3 & C4 in pre-eclamptic patients was lower than in those without pre-eclamsia. It is suggested that decreased level of these complements can be considered as a predictive factor of pre-eclampsia. More studies are warranted in this field. Key words: Preeclampsia, complement (C3 & C4), pregnancyhttp://jims.mui.ac.ir/index.php/jims/article/view/34 |
| spellingShingle | Shahnaz Aram Ali Shahbazi Comparison of the Mean Level of C3 & C4 Complements in Pre-eclamptic Patients and Normal Pregnancy مجله دانشکده پزشکی اصفهان |
| title | Comparison of the Mean Level of C3 & C4 Complements in Pre-eclamptic Patients and Normal Pregnancy |
| title_full | Comparison of the Mean Level of C3 & C4 Complements in Pre-eclamptic Patients and Normal Pregnancy |
| title_fullStr | Comparison of the Mean Level of C3 & C4 Complements in Pre-eclamptic Patients and Normal Pregnancy |
| title_full_unstemmed | Comparison of the Mean Level of C3 & C4 Complements in Pre-eclamptic Patients and Normal Pregnancy |
| title_short | Comparison of the Mean Level of C3 & C4 Complements in Pre-eclamptic Patients and Normal Pregnancy |
| title_sort | comparison of the mean level of c3 c4 complements in pre eclamptic patients and normal pregnancy |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/34 |
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