Neutrophilia and its correlation with increased inflammatory response in COVID-19 in diabetic and pre-diabetic patients
Background: Hyperglycemic patients are at a high risk of COVID-19 severity. Neutrophils have been considered critical effector cells in COVID-19 development. Vitamin D deficiency is prevalent in hyperglycemic patients and was found to adversely associate with the neutrophil count. Aim: The goal of t...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-01-01
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| Series: | European Journal of Inflammation |
| Online Access: | https://doi.org/10.1177/1721727X221150338 |
| _version_ | 1797741461574254592 |
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| author | Hayaa M. Alhuthali Mazen Almehmadi Eman F. Ataya Hind A. Alzahrani Amani A. Alrehaili Maha M. Bakhuraysah Fouzeyyah Ali Alsaeedi Ahad Amer Alsaiari Mohamed M. Khalifa Amal F. Gharib |
| author_facet | Hayaa M. Alhuthali Mazen Almehmadi Eman F. Ataya Hind A. Alzahrani Amani A. Alrehaili Maha M. Bakhuraysah Fouzeyyah Ali Alsaeedi Ahad Amer Alsaiari Mohamed M. Khalifa Amal F. Gharib |
| author_sort | Hayaa M. Alhuthali |
| collection | DOAJ |
| description | Background: Hyperglycemic patients are at a high risk of COVID-19 severity. Neutrophils have been considered critical effector cells in COVID-19 development. Vitamin D deficiency is prevalent in hyperglycemic patients and was found to adversely associate with the neutrophil count. Aim: The goal of this work was to evaluate the characteristics of diabetic and pre-diabetic COVID-19 patients and discovered changes in neutrophils and their correlation, if any, with disease clinical presentation. Patients and Methods: The study included total of (514) Covid-19 positive patients confirmed by PCR and recruited from the Prince Mohammad Bin Abdulaziz Hospital in Riyadh, Saudi Arabia. Patient’s clinical characteristics were collected for all patients. Laboratory tests include HbA1c, neutrophil count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), ferritin, D- dimer, 25 hydroxy vitamin D (25(OH)D), and folate. Results: The results found that 286 patients (55.6%) were diabetic, 77 patients (15%) were pre-diabetic and 151 (29.4%) were normoglycaemic. A significant difference was exhibited regarding the neutrophil count and inflammatory factors of COVID-19 severity. Furthermore, the neutrophil count was found to be directly correlated with the severity monitoring biochemical markers for Covid-19: CRP, ESR, ferritin, and D-dimer and inversely associated with vitamin D levels in diabetic and pre-diabetic patients. Conclusion: Our findings highlight the change of neutrophils in COVID-19 diabetic and pre-diabetic patients that was found to correlate positively with CRP, ESR, ferritin, and D-dimer, and negatively with 25(OH)D, but their correlation with the clinical presentation of the disease need further large investigations. |
| first_indexed | 2024-03-12T14:27:17Z |
| format | Article |
| id | doaj.art-59e6b059fe6f4cdba8622d1e884080ad |
| institution | Directory Open Access Journal |
| issn | 2058-7392 |
| language | English |
| last_indexed | 2024-03-12T14:27:17Z |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | European Journal of Inflammation |
| spelling | doaj.art-59e6b059fe6f4cdba8622d1e884080ad2023-08-18T04:07:41ZengSAGE PublishingEuropean Journal of Inflammation2058-73922023-01-012110.1177/1721727X221150338Neutrophilia and its correlation with increased inflammatory response in COVID-19 in diabetic and pre-diabetic patientsHayaa M. AlhuthaliMazen AlmehmadiEman F. AtayaHind A. AlzahraniAmani A. AlrehailiMaha M. BakhuraysahFouzeyyah Ali AlsaeediAhad Amer AlsaiariMohamed M. KhalifaAmal F. GharibBackground: Hyperglycemic patients are at a high risk of COVID-19 severity. Neutrophils have been considered critical effector cells in COVID-19 development. Vitamin D deficiency is prevalent in hyperglycemic patients and was found to adversely associate with the neutrophil count. Aim: The goal of this work was to evaluate the characteristics of diabetic and pre-diabetic COVID-19 patients and discovered changes in neutrophils and their correlation, if any, with disease clinical presentation. Patients and Methods: The study included total of (514) Covid-19 positive patients confirmed by PCR and recruited from the Prince Mohammad Bin Abdulaziz Hospital in Riyadh, Saudi Arabia. Patient’s clinical characteristics were collected for all patients. Laboratory tests include HbA1c, neutrophil count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), ferritin, D- dimer, 25 hydroxy vitamin D (25(OH)D), and folate. Results: The results found that 286 patients (55.6%) were diabetic, 77 patients (15%) were pre-diabetic and 151 (29.4%) were normoglycaemic. A significant difference was exhibited regarding the neutrophil count and inflammatory factors of COVID-19 severity. Furthermore, the neutrophil count was found to be directly correlated with the severity monitoring biochemical markers for Covid-19: CRP, ESR, ferritin, and D-dimer and inversely associated with vitamin D levels in diabetic and pre-diabetic patients. Conclusion: Our findings highlight the change of neutrophils in COVID-19 diabetic and pre-diabetic patients that was found to correlate positively with CRP, ESR, ferritin, and D-dimer, and negatively with 25(OH)D, but their correlation with the clinical presentation of the disease need further large investigations.https://doi.org/10.1177/1721727X221150338 |
| spellingShingle | Hayaa M. Alhuthali Mazen Almehmadi Eman F. Ataya Hind A. Alzahrani Amani A. Alrehaili Maha M. Bakhuraysah Fouzeyyah Ali Alsaeedi Ahad Amer Alsaiari Mohamed M. Khalifa Amal F. Gharib Neutrophilia and its correlation with increased inflammatory response in COVID-19 in diabetic and pre-diabetic patients European Journal of Inflammation |
| title | Neutrophilia and its correlation with increased inflammatory response in COVID-19 in diabetic and pre-diabetic patients |
| title_full | Neutrophilia and its correlation with increased inflammatory response in COVID-19 in diabetic and pre-diabetic patients |
| title_fullStr | Neutrophilia and its correlation with increased inflammatory response in COVID-19 in diabetic and pre-diabetic patients |
| title_full_unstemmed | Neutrophilia and its correlation with increased inflammatory response in COVID-19 in diabetic and pre-diabetic patients |
| title_short | Neutrophilia and its correlation with increased inflammatory response in COVID-19 in diabetic and pre-diabetic patients |
| title_sort | neutrophilia and its correlation with increased inflammatory response in covid 19 in diabetic and pre diabetic patients |
| url | https://doi.org/10.1177/1721727X221150338 |
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