Role of Collagen in Airway Mechanics
Collagen is the most abundant airway extracellular matrix component and is the primary determinant of mechanical airway properties. Abnormal airway collagen deposition is associated with the pathogenesis and progression of airway disease. Thus, understanding how collagen affects healthy airway tissu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
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| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/8/1/13 |
| _version_ | 1797410758014795776 |
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| author | Lumei Liu Brooke Stephens Maxwell Bergman Anne May Tendy Chiang |
| author_facet | Lumei Liu Brooke Stephens Maxwell Bergman Anne May Tendy Chiang |
| author_sort | Lumei Liu |
| collection | DOAJ |
| description | Collagen is the most abundant airway extracellular matrix component and is the primary determinant of mechanical airway properties. Abnormal airway collagen deposition is associated with the pathogenesis and progression of airway disease. Thus, understanding how collagen affects healthy airway tissue mechanics is essential. The impact of abnormal collagen deposition and tissue stiffness has been an area of interest in pulmonary diseases such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease. In this review, we discuss (1) the role of collagen in airway mechanics, (2) macro- and micro-scale approaches to quantify airway mechanics, and (3) pathologic changes associated with collagen deposition in airway diseases. These studies provide important insights into the role of collagen in airway mechanics. We summarize their achievements and seek to provide biomechanical clues for targeted therapies and regenerative medicine to treat airway pathology and address airway defects. |
| first_indexed | 2024-03-09T04:34:50Z |
| format | Article |
| id | doaj.art-59e766d35c5149b09c69f85b569244f5 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-09T04:34:50Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-59e766d35c5149b09c69f85b569244f52023-12-03T13:30:34ZengMDPI AGBioengineering2306-53542021-01-01811310.3390/bioengineering8010013Role of Collagen in Airway MechanicsLumei Liu0Brooke Stephens1Maxwell Bergman2Anne May3Tendy Chiang4Center of Regenerative Medicine, Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43215, USACollege of Medicine, The Ohio State University, Columbus, OH 43210, USADepartment of Otolaryngology-Head & Neck Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USASection of Pulmonary Medicine, Nationwide Children’s Hospital, Columbus, OH 43205, USACenter of Regenerative Medicine, Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, OH 43215, USACollagen is the most abundant airway extracellular matrix component and is the primary determinant of mechanical airway properties. Abnormal airway collagen deposition is associated with the pathogenesis and progression of airway disease. Thus, understanding how collagen affects healthy airway tissue mechanics is essential. The impact of abnormal collagen deposition and tissue stiffness has been an area of interest in pulmonary diseases such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease. In this review, we discuss (1) the role of collagen in airway mechanics, (2) macro- and micro-scale approaches to quantify airway mechanics, and (3) pathologic changes associated with collagen deposition in airway diseases. These studies provide important insights into the role of collagen in airway mechanics. We summarize their achievements and seek to provide biomechanical clues for targeted therapies and regenerative medicine to treat airway pathology and address airway defects.https://www.mdpi.com/2306-5354/8/1/13collagenairway mechanicsstiffnessairway disease |
| spellingShingle | Lumei Liu Brooke Stephens Maxwell Bergman Anne May Tendy Chiang Role of Collagen in Airway Mechanics Bioengineering collagen airway mechanics stiffness airway disease |
| title | Role of Collagen in Airway Mechanics |
| title_full | Role of Collagen in Airway Mechanics |
| title_fullStr | Role of Collagen in Airway Mechanics |
| title_full_unstemmed | Role of Collagen in Airway Mechanics |
| title_short | Role of Collagen in Airway Mechanics |
| title_sort | role of collagen in airway mechanics |
| topic | collagen airway mechanics stiffness airway disease |
| url | https://www.mdpi.com/2306-5354/8/1/13 |
| work_keys_str_mv | AT lumeiliu roleofcollageninairwaymechanics AT brookestephens roleofcollageninairwaymechanics AT maxwellbergman roleofcollageninairwaymechanics AT annemay roleofcollageninairwaymechanics AT tendychiang roleofcollageninairwaymechanics |