Modification of a Selective NTRK2 Agonist and Confirmation of Activity in a Glaucoma-on-a-Chip Model

Modification of a Selective NTRK2 Agonist and Confirmation of Activity in a Glaucoma-on-a-Chip Model

Abstract Purpose: RNYK is a selective agonist of the neurotrophic tyrosine kinase receptor type 2 (NTRK2) which has been screened from a phage-displayed peptide library. Its sequence is SGVYKVAYDWQH, similar to a native NTRK2 ligand, that is, brain-derived neurotrophic factor (BDNF). The current stu...

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Bibliographic Details
Main Authors: Fatemeh Nafian, Shahin Yazdani, Mohammad Javad Rasaee, Babak Kamali Doust Azad, Narsis Daftarian, Mozhgan Rezaei Kanavi
Format: Article
Language:English
Published: Knowledge E 2024-03-01
Series:Journal of Ophthalmic & Vision Research
Subjects:
agonist brain-derived neurotrophic factor neuroprotection neurotrophic tyrosine receptor kinase
Online Access:https://doi.org/10.18502/jovr.v19i1.15439

Internet

https://doi.org/10.18502/jovr.v19i1.15439

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