The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty
Abstract Total knee arthroplasty (TKA) is an effective procedure for pain relief; however, the emergence of postsurgical pain remains a concern. In this study, we investigated the production of nerve growth factor (NGF) and mediators that affect NGF production and their function in the synovial flui...
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Nature Portfolio
2024-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-59685-1 |
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| author | Tomohiro Onodera Koji Iwasaki Masatake Matsuoka Yasuhide Morioka Shinji Matsubara Eiji Kondo Norimasa Iwasaki |
| author_facet | Tomohiro Onodera Koji Iwasaki Masatake Matsuoka Yasuhide Morioka Shinji Matsubara Eiji Kondo Norimasa Iwasaki |
| author_sort | Tomohiro Onodera |
| collection | DOAJ |
| description | Abstract Total knee arthroplasty (TKA) is an effective procedure for pain relief; however, the emergence of postsurgical pain remains a concern. In this study, we investigated the production of nerve growth factor (NGF) and mediators that affect NGF production and their function in the synovial fluid and plasma after TKA. This study included 19 patients (20 knees) who had rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and knee osteoarthritis (OA) who underwent TKA, categorized into OA and non-OA groups. The levels of NGF, inflammatory cytokines, and lipid mediators were analyzed before and after surgery. The intraoperative synovial fluid NGF concentration was more than seven times higher in the non-OA group than in the OA group. The intra-articular NGF levels increased significantly by more than threefold postoperatively in the OA group but not in the non-OA group. Moreover, the levels of inflammatory cytokines and lipid mediators were increased in the synovial fluid of both groups. The intra-articular cytokines or NGF concentrations positively correlated with postoperative pain. Targeted NGF control has the potential to alleviate postsurgical pain in TKA, especially in patients with OA, emphasizing the importance of understanding NGF dynamics under different knee conditions. |
| first_indexed | 2024-04-24T07:15:07Z |
| format | Article |
| id | doaj.art-59ea44335b4f4228b2bd2e24c2ef7976 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T07:15:07Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
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| spelling | doaj.art-59ea44335b4f4228b2bd2e24c2ef79762024-04-21T11:19:27ZengNature PortfolioScientific Reports2045-23222024-04-011411810.1038/s41598-024-59685-1The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplastyTomohiro Onodera0Koji Iwasaki1Masatake Matsuoka2Yasuhide Morioka3Shinji Matsubara4Eiji Kondo5Norimasa Iwasaki6Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Functional Reconstruction for the Knee Joint, Hokkaido UniversityDepartment of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityLaboratory for Drug Discovery and Disease Research, Shionogi & Co. LtdDepartment of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityCentre for Sports Medicine, Hokkaido UniversityDepartment of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityAbstract Total knee arthroplasty (TKA) is an effective procedure for pain relief; however, the emergence of postsurgical pain remains a concern. In this study, we investigated the production of nerve growth factor (NGF) and mediators that affect NGF production and their function in the synovial fluid and plasma after TKA. This study included 19 patients (20 knees) who had rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and knee osteoarthritis (OA) who underwent TKA, categorized into OA and non-OA groups. The levels of NGF, inflammatory cytokines, and lipid mediators were analyzed before and after surgery. The intraoperative synovial fluid NGF concentration was more than seven times higher in the non-OA group than in the OA group. The intra-articular NGF levels increased significantly by more than threefold postoperatively in the OA group but not in the non-OA group. Moreover, the levels of inflammatory cytokines and lipid mediators were increased in the synovial fluid of both groups. The intra-articular cytokines or NGF concentrations positively correlated with postoperative pain. Targeted NGF control has the potential to alleviate postsurgical pain in TKA, especially in patients with OA, emphasizing the importance of understanding NGF dynamics under different knee conditions.https://doi.org/10.1038/s41598-024-59685-1Total knee arthroplastyOsteoarthritisPostoperative painNerve growth factor |
| spellingShingle | Tomohiro Onodera Koji Iwasaki Masatake Matsuoka Yasuhide Morioka Shinji Matsubara Eiji Kondo Norimasa Iwasaki The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty Scientific Reports Total knee arthroplasty Osteoarthritis Postoperative pain Nerve growth factor |
| title | The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty |
| title_full | The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty |
| title_fullStr | The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty |
| title_full_unstemmed | The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty |
| title_short | The alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty |
| title_sort | alterations in nerve growth factor concentration in plasma and synovial fluid before and after total knee arthroplasty |
| topic | Total knee arthroplasty Osteoarthritis Postoperative pain Nerve growth factor |
| url | https://doi.org/10.1038/s41598-024-59685-1 |
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