Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms
Long-term or supra-physiological dose of glucocorticoid (GC) application in clinic can lead to impaired bone growth and osteoporosis. The side effects of GC on the skeletal system are particularly serious in growing children, potentially causing growth retardation or even osteoporotic fractures. Chi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1119427/full |
| _version_ | 1797852576976207872 |
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| author | Junying Hua Jianping Huang Gang Li Gang Li Sien Lin Sien Lin Sien Lin Liao Cui |
| author_facet | Junying Hua Jianping Huang Gang Li Gang Li Sien Lin Sien Lin Sien Lin Liao Cui |
| author_sort | Junying Hua |
| collection | DOAJ |
| description | Long-term or supra-physiological dose of glucocorticoid (GC) application in clinic can lead to impaired bone growth and osteoporosis. The side effects of GC on the skeletal system are particularly serious in growing children, potentially causing growth retardation or even osteoporotic fractures. Children’s bone growth is dependent on endochondral ossification of growth plate chondrocytes, and excessive GC can hinder the development of growth plate and longitudinal bone growth. Despite the availability of drugs for treating osteoporosis, they have failed to effectively prevent or treat longitudinal bone growth and development disorders caused by GCs. As of now, there is no specific drug to mitigate these severe side effects. Traditional Chinese Medicine shows potential as an alternative to the current treatments by eliminating the side effects of GC. In summary, this article comprehensively reviews the research frontiers concerning growth and development disorders resulting from supra-physiological levels of GC and discusses the future research and treatment directions for optimizing steroid therapy. This article may also provide theoretical and experimental insight into the research and development of novel drugs to prevent GC-related side effects. |
| first_indexed | 2024-04-09T19:36:33Z |
| format | Article |
| id | doaj.art-59ec22f491ce47b4ade6073b0c512de2 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T19:36:33Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-59ec22f491ce47b4ade6073b0c512de22023-04-04T10:04:28ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-04-011410.3389/fendo.2023.11194271119427Glucocorticoid induced bone disorders in children: Research progress in treatment mechanismsJunying Hua0Jianping Huang1Gang Li2Gang Li3Sien Lin4Sien Lin5Sien Lin6Liao Cui7Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Zhanjiang, ChinaDepartment of Prosthodontics, Yonsei University College of Dentistry, Seoul, Republic of KoreaMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaStem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaMusculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaStem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, ChinaOrthopaedic Center, Affiliated Hospital of Guangdong Medical University, Guangdong Medical University, Zhanjiang, ChinaGuangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Zhanjiang, ChinaLong-term or supra-physiological dose of glucocorticoid (GC) application in clinic can lead to impaired bone growth and osteoporosis. The side effects of GC on the skeletal system are particularly serious in growing children, potentially causing growth retardation or even osteoporotic fractures. Children’s bone growth is dependent on endochondral ossification of growth plate chondrocytes, and excessive GC can hinder the development of growth plate and longitudinal bone growth. Despite the availability of drugs for treating osteoporosis, they have failed to effectively prevent or treat longitudinal bone growth and development disorders caused by GCs. As of now, there is no specific drug to mitigate these severe side effects. Traditional Chinese Medicine shows potential as an alternative to the current treatments by eliminating the side effects of GC. In summary, this article comprehensively reviews the research frontiers concerning growth and development disorders resulting from supra-physiological levels of GC and discusses the future research and treatment directions for optimizing steroid therapy. This article may also provide theoretical and experimental insight into the research and development of novel drugs to prevent GC-related side effects.https://www.frontiersin.org/articles/10.3389/fendo.2023.1119427/fullgrowth hormonegrowth platebone growth suppressionglucocorticoid (GC)chondrocyte 3 |
| spellingShingle | Junying Hua Jianping Huang Gang Li Gang Li Sien Lin Sien Lin Sien Lin Liao Cui Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms Frontiers in Endocrinology growth hormone growth plate bone growth suppression glucocorticoid (GC) chondrocyte 3 |
| title | Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms |
| title_full | Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms |
| title_fullStr | Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms |
| title_full_unstemmed | Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms |
| title_short | Glucocorticoid induced bone disorders in children: Research progress in treatment mechanisms |
| title_sort | glucocorticoid induced bone disorders in children research progress in treatment mechanisms |
| topic | growth hormone growth plate bone growth suppression glucocorticoid (GC) chondrocyte 3 |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1119427/full |
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