Antiviral Natural Products for Arbovirus Infections
Over the course of the last 50 years, the emergence of several arboviruses have resulted in countless outbreaks globally. With a high proportion of infections occurring in tropical and subtropical regions where arthropods tend to be abundant, Asia in particular is a region that is heavily affected b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/12/2796 |
| _version_ | 1797565015953244160 |
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| author | Vanessa Shi Li Goh Chee-Keng Mok Justin Jang Hann Chu |
| author_facet | Vanessa Shi Li Goh Chee-Keng Mok Justin Jang Hann Chu |
| author_sort | Vanessa Shi Li Goh |
| collection | DOAJ |
| description | Over the course of the last 50 years, the emergence of several arboviruses have resulted in countless outbreaks globally. With a high proportion of infections occurring in tropical and subtropical regions where arthropods tend to be abundant, Asia in particular is a region that is heavily affected by arboviral diseases caused by dengue, Japanese encephalitis, West Nile, Zika, and chikungunya viruses. Major gaps in protection against the most significant emerging arboviruses remains as there are currently no antivirals available, and vaccines are only available for some. A potential source of antiviral compounds could be discovered in natural products—such as vegetables, fruits, flowers, herbal plants, marine organisms and microorganisms—from which various compounds have been documented to exhibit antiviral activities and are expected to have good tolerability and minimal side effects. Polyphenols and plant extracts have been extensively studied for their antiviral properties against arboviruses and have demonstrated promising results. With an abundance of natural products to screen for new antiviral compounds, it is highly optimistic that natural products will continue to play an important role in contributing to antiviral drug development and in reducing the global infection burden of arboviruses. |
| first_indexed | 2024-03-10T19:06:03Z |
| format | Article |
| id | doaj.art-59ed22e7270240b29f0141427dc61972 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:06:03Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-59ed22e7270240b29f0141427dc619722023-11-20T04:07:36ZengMDPI AGMolecules1420-30492020-06-012512279610.3390/molecules25122796Antiviral Natural Products for Arbovirus InfectionsVanessa Shi Li Goh0Chee-Keng Mok1Justin Jang Hann Chu2Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, SingaporeLaboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, SingaporeLaboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, SingaporeOver the course of the last 50 years, the emergence of several arboviruses have resulted in countless outbreaks globally. With a high proportion of infections occurring in tropical and subtropical regions where arthropods tend to be abundant, Asia in particular is a region that is heavily affected by arboviral diseases caused by dengue, Japanese encephalitis, West Nile, Zika, and chikungunya viruses. Major gaps in protection against the most significant emerging arboviruses remains as there are currently no antivirals available, and vaccines are only available for some. A potential source of antiviral compounds could be discovered in natural products—such as vegetables, fruits, flowers, herbal plants, marine organisms and microorganisms—from which various compounds have been documented to exhibit antiviral activities and are expected to have good tolerability and minimal side effects. Polyphenols and plant extracts have been extensively studied for their antiviral properties against arboviruses and have demonstrated promising results. With an abundance of natural products to screen for new antiviral compounds, it is highly optimistic that natural products will continue to play an important role in contributing to antiviral drug development and in reducing the global infection burden of arboviruses.https://www.mdpi.com/1420-3049/25/12/2796antiviralnatural productsarbovirus |
| spellingShingle | Vanessa Shi Li Goh Chee-Keng Mok Justin Jang Hann Chu Antiviral Natural Products for Arbovirus Infections Molecules antiviral natural products arbovirus |
| title | Antiviral Natural Products for Arbovirus Infections |
| title_full | Antiviral Natural Products for Arbovirus Infections |
| title_fullStr | Antiviral Natural Products for Arbovirus Infections |
| title_full_unstemmed | Antiviral Natural Products for Arbovirus Infections |
| title_short | Antiviral Natural Products for Arbovirus Infections |
| title_sort | antiviral natural products for arbovirus infections |
| topic | antiviral natural products arbovirus |
| url | https://www.mdpi.com/1420-3049/25/12/2796 |
| work_keys_str_mv | AT vanessashiligoh antiviralnaturalproductsforarbovirusinfections AT cheekengmok antiviralnaturalproductsforarbovirusinfections AT justinjanghannchu antiviralnaturalproductsforarbovirusinfections |