Evaluation of Radiosensitivity of HeLa Cells Infected with Polio Virus Irradiated by Co 60
ABSTRACT: Introduction & Objective: The main purpose of radiotherapy is exposing enough doses of radiation to tumor tissue and protecting the normal tissues around it. Tumor dose for each session in radiotherapy will be considered based on radiosensitivity of the tissues. The presence of vira...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Yasuj University Of Medical Sciences
2008-04-01
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| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-39-16&slc_lang=en&sid=1 |
| _version_ | 1797991965142286336 |
|---|---|
| author | F Seif MR Baiatiani Kheirolah MJ Baiatiani Kheirolah M Ansari A Sohrabi F Hosseini |
| author_facet | F Seif MR Baiatiani Kheirolah MJ Baiatiani Kheirolah M Ansari A Sohrabi F Hosseini |
| author_sort | F Seif |
| collection | DOAJ |
| description | ABSTRACT:
Introduction & Objective: The main purpose of radiotherapy is exposing enough doses of radiation to tumor tissue and protecting the normal tissues around it. Tumor dose for each session in radiotherapy will be considered based on radiosensitivity of the tissues. The presence of viral diseases in tumoral area can affect the radiosensitivity of cells. This study aimed to evaluate the radiosensitivity of Hela cells infected with poliomyelitis virus irradiated by Co 60.
Materials & Methods: In this study, the radiosensitivity of HeLa cells, with or without the viral infection, after gamma radiation of cobalt 60, was assessed.
Results: Results of comparison of the radisensitivity of infected and uninfected cells indicates that after 2 Gy irradiation by Co 60, polio infection in low, moderate and high virus load, increases the cell death by 20-30%, 30-40% and 70-90% respectively.
Conclusion : Radiosensitivity of tumoral cells increase when they are infected with viral agents. Results of this study showed that non cancer diseases should be considered when prescribing dose fraction in radiotherapy of cancers. |
| first_indexed | 2024-04-11T09:00:28Z |
| format | Article |
| id | doaj.art-59ed6501ae74474194339be3f957bae9 |
| institution | Directory Open Access Journal |
| issn | 1728-6506 1728-6514 |
| language | fas |
| last_indexed | 2024-04-11T09:00:28Z |
| publishDate | 2008-04-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-59ed6501ae74474194339be3f957bae92022-12-22T04:32:48ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65061728-65142008-04-011318995Evaluation of Radiosensitivity of HeLa Cells Infected with Polio Virus Irradiated by Co 60F Seif0MR Baiatiani Kheirolah1MJ Baiatiani Kheirolah2M Ansari3A Sohrabi4F Hosseini5 ABSTRACT: Introduction & Objective: The main purpose of radiotherapy is exposing enough doses of radiation to tumor tissue and protecting the normal tissues around it. Tumor dose for each session in radiotherapy will be considered based on radiosensitivity of the tissues. The presence of viral diseases in tumoral area can affect the radiosensitivity of cells. This study aimed to evaluate the radiosensitivity of Hela cells infected with poliomyelitis virus irradiated by Co 60. Materials & Methods: In this study, the radiosensitivity of HeLa cells, with or without the viral infection, after gamma radiation of cobalt 60, was assessed. Results: Results of comparison of the radisensitivity of infected and uninfected cells indicates that after 2 Gy irradiation by Co 60, polio infection in low, moderate and high virus load, increases the cell death by 20-30%, 30-40% and 70-90% respectively. Conclusion : Radiosensitivity of tumoral cells increase when they are infected with viral agents. Results of this study showed that non cancer diseases should be considered when prescribing dose fraction in radiotherapy of cancers.http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-39-16&slc_lang=en&sid=1KEYWORDS:Radiosensitivity HeLa Cells Polio Virus |
| spellingShingle | F Seif MR Baiatiani Kheirolah MJ Baiatiani Kheirolah M Ansari A Sohrabi F Hosseini Evaluation of Radiosensitivity of HeLa Cells Infected with Polio Virus Irradiated by Co 60 Armaghane Danesh Bimonthly Journal KEYWORDS:Radiosensitivity HeLa Cells Polio Virus |
| title | Evaluation of Radiosensitivity of HeLa Cells Infected with Polio Virus Irradiated by Co 60 |
| title_full | Evaluation of Radiosensitivity of HeLa Cells Infected with Polio Virus Irradiated by Co 60 |
| title_fullStr | Evaluation of Radiosensitivity of HeLa Cells Infected with Polio Virus Irradiated by Co 60 |
| title_full_unstemmed | Evaluation of Radiosensitivity of HeLa Cells Infected with Polio Virus Irradiated by Co 60 |
| title_short | Evaluation of Radiosensitivity of HeLa Cells Infected with Polio Virus Irradiated by Co 60 |
| title_sort | evaluation of radiosensitivity of hela cells infected with polio virus irradiated by co 60 |
| topic | KEYWORDS:Radiosensitivity HeLa Cells Polio Virus |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-39-16&slc_lang=en&sid=1 |
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