Survival of bronchopulmonary cancers according to radon exposure
IntroductionResidential exposure is estimated to be responsible for nearly 10% of lung cancers in 2015 in France, making it the second leading cause, after tobacco. The Auvergne-Rhône-Alpes region, in the southwest of France, is particularly affected by this exposure as 30% of the population lives i...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1306455/full |
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| author | Juliette Dessemon Juliette Dessemon Olivia Perol Olivia Perol Cécile Chauvel Cécile Chauvel Hugo Noelle Hugo Noelle Thomas Coudon Thomas Coudon Lény Grassot Lény Grassot Nicolas Foray Elodie Belladame Elodie Belladame Jérôme Fayette Françoise Fournie Aurélie Swalduz Eve-Marie Neidhart Pierre Saintigny Mayeul Tabutin Maxime Boussageon Frédéric Gomez Virginie Avrillon Maurice Perol Barbara Charbotel Barbara Charbotel Béatrice Fervers Béatrice Fervers |
| author_facet | Juliette Dessemon Juliette Dessemon Olivia Perol Olivia Perol Cécile Chauvel Cécile Chauvel Hugo Noelle Hugo Noelle Thomas Coudon Thomas Coudon Lény Grassot Lény Grassot Nicolas Foray Elodie Belladame Elodie Belladame Jérôme Fayette Françoise Fournie Aurélie Swalduz Eve-Marie Neidhart Pierre Saintigny Mayeul Tabutin Maxime Boussageon Frédéric Gomez Virginie Avrillon Maurice Perol Barbara Charbotel Barbara Charbotel Béatrice Fervers Béatrice Fervers |
| author_sort | Juliette Dessemon |
| collection | DOAJ |
| description | IntroductionResidential exposure is estimated to be responsible for nearly 10% of lung cancers in 2015 in France, making it the second leading cause, after tobacco. The Auvergne-Rhône-Alpes region, in the southwest of France, is particularly affected by this exposure as 30% of the population lives in areas with medium or high radon potential. This study aimed to investigate the impact of radon exposure on the survival of lung cancer patients.MethodsIn this single-center study, patients with a histologically confirmed diagnosis of lung cancer, and newly managed, were prospectively included between 2014 and 2020. Univariate and multivariate survival analyses were carried out using a non-proportional risk survival model to consider variations in risk over time.ResultsA total of 1,477 patients were included in the analysis. In the multivariate analysis and after adjustment for covariates, radon exposure was not statistically associated with survival of bronchopulmonary cancers (HR = 0.82 [0.54–1.23], HR = 0.92 [0.72–1.18], HR = 0.95 [0.76–1.19] at 1, 3, and 5 years, respectively, for patients residing in category 2 municipalities; HR = 0.87 [0.66–1.16], HR = 0.92 [0.76–1.10], and HR = 0.89 [0.75–1.06] at 1, 3, and 5 years, respectively, for patients residing in category 3 municipalities).DiscussionAlthough radon exposure is known to increase the risk of lung cancer, in the present study, no significant association was found between radon exposure and survival of bronchopulmonary cancers. |
| first_indexed | 2024-03-08T11:55:22Z |
| format | Article |
| id | doaj.art-59eed2ed0592472bacd7aa9539ba0b7b |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-08T11:55:22Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj.art-59eed2ed0592472bacd7aa9539ba0b7b2024-01-24T04:12:48ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-01-011110.3389/fpubh.2023.13064551306455Survival of bronchopulmonary cancers according to radon exposureJuliette Dessemon0Juliette Dessemon1Olivia Perol2Olivia Perol3Cécile Chauvel4Cécile Chauvel5Hugo Noelle6Hugo Noelle7Thomas Coudon8Thomas Coudon9Lény Grassot10Lény Grassot11Nicolas Foray12Elodie Belladame13Elodie Belladame14Jérôme Fayette15Françoise Fournie16Aurélie Swalduz17Eve-Marie Neidhart18Pierre Saintigny19Mayeul Tabutin20Maxime Boussageon21Frédéric Gomez22Virginie Avrillon23Maurice Perol24Barbara Charbotel25Barbara Charbotel26Béatrice Fervers27Béatrice Fervers28Département Prévention Cancer Environnement, Center Léon Bérard, Lyon, FranceFaculté de Médecine Lyon Est, Université de Lyon, Lyon, FranceDépartement Prévention Cancer Environnement, Center Léon Bérard, Lyon, FranceInserm UMR1296, “Radiation: Defense, Health Environment,” Center Léon Bérard, Lyon, FranceCenter of Excellence in Respiratory Pathogens (CERP), Hospices Civils de Lyon, Lyon, FranceCentre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Université Claude Bernard Lyon 1, Lyon, FranceDépartement Prévention Cancer Environnement, Center Léon Bérard, Lyon, FranceFaculté de Médecine Lyon Est, Université de Lyon, Lyon, FranceDépartement Prévention Cancer Environnement, Center Léon Bérard, Lyon, FranceInserm UMR1296, “Radiation: Defense, Health Environment,” Center Léon Bérard, Lyon, FranceDépartement Prévention Cancer Environnement, Center Léon Bérard, Lyon, FranceInserm UMR1296, “Radiation: Defense, Health Environment,” Center Léon Bérard, Lyon, FranceInserm UMR1296, “Radiation: Defense, Health Environment,” Center Léon Bérard, Lyon, FranceDépartement Prévention Cancer Environnement, Center Léon Bérard, Lyon, FranceInserm UMR1296, “Radiation: Defense, Health Environment,” Center Léon Bérard, Lyon, FranceDépartement de Cancérologie Médicale, Center Léon Bérard, Lyon, FranceDépartement Interdisciplinaire de Soins de Support du Patient en Oncologie, Center Léon Bérard, Lyon, FranceDépartement de Cancérologie Médicale, Center Léon Bérard, Lyon, FranceDépartement de Cancérologie Médicale, Center Léon Bérard, Lyon, FranceDépartement de Cancérologie Médicale, Center Léon Bérard, Lyon, FranceDépartement de Chirurgie Cancérologique, Center Léon Bérard, Lyon, FranceInserm UMR1296, “Radiation: Defense, Health Environment,” Center Léon Bérard, Lyon, FranceDépartement de Santé Publique, Center Léon Bérard, Lyon, FranceDépartement de Cancérologie Médicale, Center Léon Bérard, Lyon, FranceDépartement de Cancérologie Médicale, Center Léon Bérard, Lyon, France0Université de Lyon, Université Lyon 1, Université Gustave Eiffel-Ifsttar, Umrestte, UMR, Lyon, France1CRPPE-Lyon, Center Régional de Pathologies Professionnelles et Environnementales de Lyon, Center Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, FranceDépartement Prévention Cancer Environnement, Center Léon Bérard, Lyon, FranceInserm UMR1296, “Radiation: Defense, Health Environment,” Center Léon Bérard, Lyon, FranceIntroductionResidential exposure is estimated to be responsible for nearly 10% of lung cancers in 2015 in France, making it the second leading cause, after tobacco. The Auvergne-Rhône-Alpes region, in the southwest of France, is particularly affected by this exposure as 30% of the population lives in areas with medium or high radon potential. This study aimed to investigate the impact of radon exposure on the survival of lung cancer patients.MethodsIn this single-center study, patients with a histologically confirmed diagnosis of lung cancer, and newly managed, were prospectively included between 2014 and 2020. Univariate and multivariate survival analyses were carried out using a non-proportional risk survival model to consider variations in risk over time.ResultsA total of 1,477 patients were included in the analysis. In the multivariate analysis and after adjustment for covariates, radon exposure was not statistically associated with survival of bronchopulmonary cancers (HR = 0.82 [0.54–1.23], HR = 0.92 [0.72–1.18], HR = 0.95 [0.76–1.19] at 1, 3, and 5 years, respectively, for patients residing in category 2 municipalities; HR = 0.87 [0.66–1.16], HR = 0.92 [0.76–1.10], and HR = 0.89 [0.75–1.06] at 1, 3, and 5 years, respectively, for patients residing in category 3 municipalities).DiscussionAlthough radon exposure is known to increase the risk of lung cancer, in the present study, no significant association was found between radon exposure and survival of bronchopulmonary cancers.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1306455/fullradonlung cancersurvivalenvironmental exposurepublic health |
| spellingShingle | Juliette Dessemon Juliette Dessemon Olivia Perol Olivia Perol Cécile Chauvel Cécile Chauvel Hugo Noelle Hugo Noelle Thomas Coudon Thomas Coudon Lény Grassot Lény Grassot Nicolas Foray Elodie Belladame Elodie Belladame Jérôme Fayette Françoise Fournie Aurélie Swalduz Eve-Marie Neidhart Pierre Saintigny Mayeul Tabutin Maxime Boussageon Frédéric Gomez Virginie Avrillon Maurice Perol Barbara Charbotel Barbara Charbotel Béatrice Fervers Béatrice Fervers Survival of bronchopulmonary cancers according to radon exposure Frontiers in Public Health radon lung cancer survival environmental exposure public health |
| title | Survival of bronchopulmonary cancers according to radon exposure |
| title_full | Survival of bronchopulmonary cancers according to radon exposure |
| title_fullStr | Survival of bronchopulmonary cancers according to radon exposure |
| title_full_unstemmed | Survival of bronchopulmonary cancers according to radon exposure |
| title_short | Survival of bronchopulmonary cancers according to radon exposure |
| title_sort | survival of bronchopulmonary cancers according to radon exposure |
| topic | radon lung cancer survival environmental exposure public health |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1306455/full |
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