Learning Curve for Starting a Successful Single-Centre TAVR Programme with Multiple Devices: Early and Mid-Term Follow-Up
<b>Aims:</b> We report 30-day, 1-year, and 3-year outcomes for a new TAVR programme that used five different transcatheter heart valve (THV) systems. <b>Methods:</b> From 2014 to 2020, 122 consecutive patients with severe aortic stenosis (AS) received TAVR based on the Heart...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/4/1088 |
| _version_ | 1797297869069221888 |
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| author | Balázs Magyari Bálint Kittka Ilona Goják Kristóf Schönfeld László Botond Szapáry Mihály Simon Rudolf Kiss Andrea Bertalan Edit Várady András Gyimesi István Szokodi Iván Gábor Horváth |
| author_facet | Balázs Magyari Bálint Kittka Ilona Goják Kristóf Schönfeld László Botond Szapáry Mihály Simon Rudolf Kiss Andrea Bertalan Edit Várady András Gyimesi István Szokodi Iván Gábor Horváth |
| author_sort | Balázs Magyari |
| collection | DOAJ |
| description | <b>Aims:</b> We report 30-day, 1-year, and 3-year outcomes for a new TAVR programme that used five different transcatheter heart valve (THV) systems. <b>Methods:</b> From 2014 to 2020, 122 consecutive patients with severe aortic stenosis (AS) received TAVR based on the Heart Team decision. Outcomes were analysed for the whole study population and in addition the first 63 patients (Cohort A, 2014 to 2019) were compared to the last 59 patients (Cohort B, 2019 to 2020). Outcomes included VARC-2 definitions and device performance assessed via transthoracic echocardiography by independent high-volume investigators. <b>Results:</b> The mean patient age was 77.9 ± 6.1 years old, and 48 (39.3%) were male. The mean logistic Euroscore II was 4.2 ± 4.5, and the mean STS score was 6.9 ± 4.68. The systems used were as follows: Medtronic Corevalve Evolute R/PRO (82 patients—67.2%); Abbott Portico (13—10.6%); Boston Scientific Lotus (10—8.2%); Meril Myval (11—9%); and Boston Scientific Neo Accurate (6—5%). Access was transfemoral (95.9% of patients); surgical cut down (18% vs. percutaneous 77.8%); subclavian (<i>n</i> = 2); trans-axillary (<i>n</i> = 2); and direct aorta (<i>n</i> = 1). VARC-2 outcomes were as follows: device success rate 97.5%; stroke rate 1.6%; major vascular complication 3.3%; permanent pacemaker implantation 12.4%. At discharge, the incidences of grade I and II aortic regurgitation were 39.95 and 55.5%, respectively. At one year, all-cause mortality was 7.4% without admissions for valve-related dysfunction. The 3-year all-cause mortality and all-stroke rates were 22.9% and 4.1%, respectively. Between the 1-year and 3-year follow-ups, valve-related dysfunction was detected in three patients; one had THV system endocarditis that led to death. There was a remarkable but statistically non-significant decrease in mortality from Cohort A to Cohort B [four (6.3%) vs. one patient (1.7%), <i>p</i> = 0.195] and major vascular complications occurred at a significantly higher rate in the Cohort B [zero (0%) vs. four (6.8% patient, <i>p</i> = 0.036)]. Overall, we found that using multiple devices was safe and allowed for a learning team to achieve a high device success rate from the beginning (97.5%). <b>Conclusions:</b> TAVR with different THV systems showed acceptable early and mid-term outcomes for survival, technical success, and valve-related adverse events in high-risk patients with significant AS, even in the learning curve phase. |
| first_indexed | 2024-03-07T22:26:37Z |
| format | Article |
| id | doaj.art-59f021c2706c4d1bb83c7118f881c9f9 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-07T22:26:37Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-59f021c2706c4d1bb83c7118f881c9f92024-02-23T15:22:15ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01134108810.3390/jcm13041088Learning Curve for Starting a Successful Single-Centre TAVR Programme with Multiple Devices: Early and Mid-Term Follow-UpBalázs Magyari0Bálint Kittka1Ilona Goják2Kristóf Schönfeld3László Botond Szapáry4Mihály Simon5Rudolf Kiss6Andrea Bertalan7Edit Várady8András Gyimesi9István Szokodi10Iván Gábor Horváth11Heart Institute, Medical School, University of Pécs, 7624 Pécs, HungaryHeart Institute, Medical School, University of Pécs, 7624 Pécs, HungaryHeart Institute, Medical School, University of Pécs, 7624 Pécs, HungaryHeart Institute, Medical School, University of Pécs, 7624 Pécs, HungaryHeart Institute, Medical School, University of Pécs, 7624 Pécs, HungaryHeart Institute, Medical School, University of Pécs, 7624 Pécs, HungaryHeart Institute, Medical School, University of Pécs, 7624 Pécs, HungaryHeart Institute, Medical School, University of Pécs, 7624 Pécs, HungaryDepartment of Medical Imaging, Medical School, University of Pécs, 7624 Pécs, HungaryEconNet Research Group, Faculty of Business and Economics, University of Pécs, 7624 Pécs, HungaryHeart Institute, Medical School, University of Pécs, 7624 Pécs, HungaryHeart Institute, Medical School, University of Pécs, 7624 Pécs, Hungary<b>Aims:</b> We report 30-day, 1-year, and 3-year outcomes for a new TAVR programme that used five different transcatheter heart valve (THV) systems. <b>Methods:</b> From 2014 to 2020, 122 consecutive patients with severe aortic stenosis (AS) received TAVR based on the Heart Team decision. Outcomes were analysed for the whole study population and in addition the first 63 patients (Cohort A, 2014 to 2019) were compared to the last 59 patients (Cohort B, 2019 to 2020). Outcomes included VARC-2 definitions and device performance assessed via transthoracic echocardiography by independent high-volume investigators. <b>Results:</b> The mean patient age was 77.9 ± 6.1 years old, and 48 (39.3%) were male. The mean logistic Euroscore II was 4.2 ± 4.5, and the mean STS score was 6.9 ± 4.68. The systems used were as follows: Medtronic Corevalve Evolute R/PRO (82 patients—67.2%); Abbott Portico (13—10.6%); Boston Scientific Lotus (10—8.2%); Meril Myval (11—9%); and Boston Scientific Neo Accurate (6—5%). Access was transfemoral (95.9% of patients); surgical cut down (18% vs. percutaneous 77.8%); subclavian (<i>n</i> = 2); trans-axillary (<i>n</i> = 2); and direct aorta (<i>n</i> = 1). VARC-2 outcomes were as follows: device success rate 97.5%; stroke rate 1.6%; major vascular complication 3.3%; permanent pacemaker implantation 12.4%. At discharge, the incidences of grade I and II aortic regurgitation were 39.95 and 55.5%, respectively. At one year, all-cause mortality was 7.4% without admissions for valve-related dysfunction. The 3-year all-cause mortality and all-stroke rates were 22.9% and 4.1%, respectively. Between the 1-year and 3-year follow-ups, valve-related dysfunction was detected in three patients; one had THV system endocarditis that led to death. There was a remarkable but statistically non-significant decrease in mortality from Cohort A to Cohort B [four (6.3%) vs. one patient (1.7%), <i>p</i> = 0.195] and major vascular complications occurred at a significantly higher rate in the Cohort B [zero (0%) vs. four (6.8% patient, <i>p</i> = 0.036)]. Overall, we found that using multiple devices was safe and allowed for a learning team to achieve a high device success rate from the beginning (97.5%). <b>Conclusions:</b> TAVR with different THV systems showed acceptable early and mid-term outcomes for survival, technical success, and valve-related adverse events in high-risk patients with significant AS, even in the learning curve phase.https://www.mdpi.com/2077-0383/13/4/1088TAVRlearning curveself-expandable transcatheter heart valveballoon-expandable transcatheter heart valveparavalvular leakbicuspid aortic valve and radial paradox |
| spellingShingle | Balázs Magyari Bálint Kittka Ilona Goják Kristóf Schönfeld László Botond Szapáry Mihály Simon Rudolf Kiss Andrea Bertalan Edit Várady András Gyimesi István Szokodi Iván Gábor Horváth Learning Curve for Starting a Successful Single-Centre TAVR Programme with Multiple Devices: Early and Mid-Term Follow-Up Journal of Clinical Medicine TAVR learning curve self-expandable transcatheter heart valve balloon-expandable transcatheter heart valve paravalvular leak bicuspid aortic valve and radial paradox |
| title | Learning Curve for Starting a Successful Single-Centre TAVR Programme with Multiple Devices: Early and Mid-Term Follow-Up |
| title_full | Learning Curve for Starting a Successful Single-Centre TAVR Programme with Multiple Devices: Early and Mid-Term Follow-Up |
| title_fullStr | Learning Curve for Starting a Successful Single-Centre TAVR Programme with Multiple Devices: Early and Mid-Term Follow-Up |
| title_full_unstemmed | Learning Curve for Starting a Successful Single-Centre TAVR Programme with Multiple Devices: Early and Mid-Term Follow-Up |
| title_short | Learning Curve for Starting a Successful Single-Centre TAVR Programme with Multiple Devices: Early and Mid-Term Follow-Up |
| title_sort | learning curve for starting a successful single centre tavr programme with multiple devices early and mid term follow up |
| topic | TAVR learning curve self-expandable transcatheter heart valve balloon-expandable transcatheter heart valve paravalvular leak bicuspid aortic valve and radial paradox |
| url | https://www.mdpi.com/2077-0383/13/4/1088 |
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