Clinical application of the Panbio™ COVID-19 Ag rapid test device and SSf-COVID19 kit for the detection of SARS-CoV-2 infection
Abstract Objective We evaluated the sensitivity and specificity of the Panbio™ COVID-19 Ag rapid test device using nasal swabs and those of the SSf-COVID19 kit, one of RT-PCR tests, using saliva specimens. These tests were compared with RT-PCR tests using nasopharyngeal swabs for the diagnosis of SA...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
|
| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13104-022-06226-6 |
| _version_ | 1811301693622583296 |
|---|---|
| author | Sang-Min Oh Jee-Soo Lee Hyeon Jae Jo Donghwan Kim Dohyeon Park Young Hoon Hwang Yunsang Choi Chan Mi Lee Seungjae Lee Euijin Chang Eunyoung Lee Taek Soo Kim Moon-Woo Seong Pyoeng Gyun Choe Nam Joong Kim |
| author_facet | Sang-Min Oh Jee-Soo Lee Hyeon Jae Jo Donghwan Kim Dohyeon Park Young Hoon Hwang Yunsang Choi Chan Mi Lee Seungjae Lee Euijin Chang Eunyoung Lee Taek Soo Kim Moon-Woo Seong Pyoeng Gyun Choe Nam Joong Kim |
| author_sort | Sang-Min Oh |
| collection | DOAJ |
| description | Abstract Objective We evaluated the sensitivity and specificity of the Panbio™ COVID-19 Ag rapid test device using nasal swabs and those of the SSf-COVID19 kit, one of RT-PCR tests, using saliva specimens. These tests were compared with RT-PCR tests using nasopharyngeal swabs for the diagnosis of SARS-CoV-2 infection. The three diagnostic tests were simultaneously conducted for patients aged ≥ 18 years, who were about to be hospitalized or had been admitted for COVID-19 confirmed by RT-PCR in two research hospitals from August 20 to October 29, 2021. Nasal swabs were tested using the Panbio™ COVID-19 Ag rapid test device. More than 1 mL of saliva was self-collected and tested using the SSf-COVID19 kit. Results In total, 157 patients were investigated; 124 patients who were about to be hospitalized and 33 patients already admitted for COVID-19. The overall sensitivity and specificity of the Panbio™ COVID-19 Ag rapid test device with nasal swabs were 64.7% (95% confidence interval [CI] 47.9–78.5%) and 100.0% (95% CI 97.0–100.0%), respectively. The median time to confirm a positive result was 180 s (interquartile range 60–255 s). The overall sensitivity and specificity of the SSf-COVID19 kit with saliva specimens were 94.1% (95% CI 80.9–98.4%) and 100.0% (95% CI 97.0–100.0%), respectively. |
| first_indexed | 2024-04-13T07:13:16Z |
| format | Article |
| id | doaj.art-59f17178197f493d81d80a7ae45a1d96 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-04-13T07:13:16Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-59f17178197f493d81d80a7ae45a1d962022-12-22T02:56:49ZengBMCBMC Research Notes1756-05002022-12-011511410.1186/s13104-022-06226-6Clinical application of the Panbio™ COVID-19 Ag rapid test device and SSf-COVID19 kit for the detection of SARS-CoV-2 infectionSang-Min Oh0Jee-Soo Lee1Hyeon Jae Jo2Donghwan Kim3Dohyeon Park4Young Hoon Hwang5Yunsang Choi6Chan Mi Lee7Seungjae Lee8Euijin Chang9Eunyoung Lee10Taek Soo Kim11Moon-Woo Seong12Pyoeng Gyun Choe13Nam Joong Kim14Department of Internal Medicine, Seoul National University College of MedicineDepartment of Laboratory Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Laboratory Medicine, Seoul National University College of MedicineDepartment of Laboratory Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineAbstract Objective We evaluated the sensitivity and specificity of the Panbio™ COVID-19 Ag rapid test device using nasal swabs and those of the SSf-COVID19 kit, one of RT-PCR tests, using saliva specimens. These tests were compared with RT-PCR tests using nasopharyngeal swabs for the diagnosis of SARS-CoV-2 infection. The three diagnostic tests were simultaneously conducted for patients aged ≥ 18 years, who were about to be hospitalized or had been admitted for COVID-19 confirmed by RT-PCR in two research hospitals from August 20 to October 29, 2021. Nasal swabs were tested using the Panbio™ COVID-19 Ag rapid test device. More than 1 mL of saliva was self-collected and tested using the SSf-COVID19 kit. Results In total, 157 patients were investigated; 124 patients who were about to be hospitalized and 33 patients already admitted for COVID-19. The overall sensitivity and specificity of the Panbio™ COVID-19 Ag rapid test device with nasal swabs were 64.7% (95% confidence interval [CI] 47.9–78.5%) and 100.0% (95% CI 97.0–100.0%), respectively. The median time to confirm a positive result was 180 s (interquartile range 60–255 s). The overall sensitivity and specificity of the SSf-COVID19 kit with saliva specimens were 94.1% (95% CI 80.9–98.4%) and 100.0% (95% CI 97.0–100.0%), respectively.https://doi.org/10.1186/s13104-022-06226-6COVID-19SARS-CoV-2RT-PCRSalivaAntigen |
| spellingShingle | Sang-Min Oh Jee-Soo Lee Hyeon Jae Jo Donghwan Kim Dohyeon Park Young Hoon Hwang Yunsang Choi Chan Mi Lee Seungjae Lee Euijin Chang Eunyoung Lee Taek Soo Kim Moon-Woo Seong Pyoeng Gyun Choe Nam Joong Kim Clinical application of the Panbio™ COVID-19 Ag rapid test device and SSf-COVID19 kit for the detection of SARS-CoV-2 infection BMC Research Notes COVID-19 SARS-CoV-2 RT-PCR Saliva Antigen |
| title | Clinical application of the Panbio™ COVID-19 Ag rapid test device and SSf-COVID19 kit for the detection of SARS-CoV-2 infection |
| title_full | Clinical application of the Panbio™ COVID-19 Ag rapid test device and SSf-COVID19 kit for the detection of SARS-CoV-2 infection |
| title_fullStr | Clinical application of the Panbio™ COVID-19 Ag rapid test device and SSf-COVID19 kit for the detection of SARS-CoV-2 infection |
| title_full_unstemmed | Clinical application of the Panbio™ COVID-19 Ag rapid test device and SSf-COVID19 kit for the detection of SARS-CoV-2 infection |
| title_short | Clinical application of the Panbio™ COVID-19 Ag rapid test device and SSf-COVID19 kit for the detection of SARS-CoV-2 infection |
| title_sort | clinical application of the panbio™ covid 19 ag rapid test device and ssf covid19 kit for the detection of sars cov 2 infection |
| topic | COVID-19 SARS-CoV-2 RT-PCR Saliva Antigen |
| url | https://doi.org/10.1186/s13104-022-06226-6 |
| work_keys_str_mv | AT sangminoh clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT jeesoolee clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT hyeonjaejo clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT donghwankim clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT dohyeonpark clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT younghoonhwang clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT yunsangchoi clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT chanmilee clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT seungjaelee clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT euijinchang clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT eunyounglee clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT taeksookim clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT moonwooseong clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT pyoenggyunchoe clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection AT namjoongkim clinicalapplicationofthepanbiocovid19agrapidtestdeviceandssfcovid19kitforthedetectionofsarscov2infection |