Generation of an induced pluripotent stem cell line (SDASi001-A) from a Schimke immune-osseous dysplasia patient with SMARCAL1 mutations
A human induced pluripotent stem cell (iPSC) line (SDASi001-A) was generated from patient with Schimke immune-osseous dysplasia (SIOD), carrying heterozygous mutations in SMARCAL1 gene. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using non-integrating delivery of OCT4, SOX2, KFL4, B...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506123002039 |
| _version_ | 1797642570318217216 |
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| author | Xingcui Wang Hongxia Zhang Xingbang Wang Weiran Zhou Linlin Dong Na Li Qiuxia He |
| author_facet | Xingcui Wang Hongxia Zhang Xingbang Wang Weiran Zhou Linlin Dong Na Li Qiuxia He |
| author_sort | Xingcui Wang |
| collection | DOAJ |
| description | A human induced pluripotent stem cell (iPSC) line (SDASi001-A) was generated from patient with Schimke immune-osseous dysplasia (SIOD), carrying heterozygous mutations in SMARCAL1 gene. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using non-integrating delivery of OCT4, SOX2, KFL4, BCL-XL and c-MYC. The iPSC line expresses pluripotency markers, displays a normal karyotype, and has the ability to differentiate into cells of three germ layers in vitro. This iPSC line represents a valuable cell model for SIOD in humans. |
| first_indexed | 2024-03-11T14:02:03Z |
| format | Article |
| id | doaj.art-59f1abf1c8794964960cddf25ed1565b |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-03-11T14:02:03Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-59f1abf1c8794964960cddf25ed1565b2023-11-02T04:13:31ZengElsevierStem Cell Research1873-50612023-10-0172103217Generation of an induced pluripotent stem cell line (SDASi001-A) from a Schimke immune-osseous dysplasia patient with SMARCAL1 mutationsXingcui Wang0Hongxia Zhang1Xingbang Wang2Weiran Zhou3Linlin Dong4Na Li5Qiuxia He6Science and Technology Service Platform, Qilu University of Technology (Shandong Academy of Sciences), Ji’nan, Shandong, China; Department of Rheumatology and Immunology, Children’s Hospital Affiliated to Shandong University, Ji’nan, Shandong, ChinaDepartment of Rheumatology and Immunology, Children’s Hospital Affiliated to Shandong University, Ji’nan, Shandong, ChinaDepartment of Geriatric Medicine, Qilu Hospital of Shandong University, Ji’nan, Shandong, ChinaDepartment of Rheumatology and Immunology, Children’s Hospital Affiliated to Shandong University, Ji’nan, Shandong, ChinaDepartment of Rheumatology and Immunology, Children’s Hospital Affiliated to Shandong University, Ji’nan, Shandong, ChinaDermatology Department, Jinan Central Hospital, Ji’nan, Shandong, China; Corresponding authors.Science and Technology Service Platform, Qilu University of Technology (Shandong Academy of Sciences), Ji’nan, Shandong, China; Corresponding authors.A human induced pluripotent stem cell (iPSC) line (SDASi001-A) was generated from patient with Schimke immune-osseous dysplasia (SIOD), carrying heterozygous mutations in SMARCAL1 gene. Peripheral blood mononuclear cells (PBMCs) were reprogrammed using non-integrating delivery of OCT4, SOX2, KFL4, BCL-XL and c-MYC. The iPSC line expresses pluripotency markers, displays a normal karyotype, and has the ability to differentiate into cells of three germ layers in vitro. This iPSC line represents a valuable cell model for SIOD in humans.http://www.sciencedirect.com/science/article/pii/S1873506123002039 |
| spellingShingle | Xingcui Wang Hongxia Zhang Xingbang Wang Weiran Zhou Linlin Dong Na Li Qiuxia He Generation of an induced pluripotent stem cell line (SDASi001-A) from a Schimke immune-osseous dysplasia patient with SMARCAL1 mutations Stem Cell Research |
| title | Generation of an induced pluripotent stem cell line (SDASi001-A) from a Schimke immune-osseous dysplasia patient with SMARCAL1 mutations |
| title_full | Generation of an induced pluripotent stem cell line (SDASi001-A) from a Schimke immune-osseous dysplasia patient with SMARCAL1 mutations |
| title_fullStr | Generation of an induced pluripotent stem cell line (SDASi001-A) from a Schimke immune-osseous dysplasia patient with SMARCAL1 mutations |
| title_full_unstemmed | Generation of an induced pluripotent stem cell line (SDASi001-A) from a Schimke immune-osseous dysplasia patient with SMARCAL1 mutations |
| title_short | Generation of an induced pluripotent stem cell line (SDASi001-A) from a Schimke immune-osseous dysplasia patient with SMARCAL1 mutations |
| title_sort | generation of an induced pluripotent stem cell line sdasi001 a from a schimke immune osseous dysplasia patient with smarcal1 mutations |
| url | http://www.sciencedirect.com/science/article/pii/S1873506123002039 |
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