Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels

Alzheimer’s disease-associated complement gene variants influence plasma complement protein levels

Abstract Background Alzheimer’s disease (AD) has been associated with immune dysregulation in biomarker and genome-wide association studies (GWAS). GWAS hits include the genes encoding complement regulators clusterin (CLU) and complement receptor 1 (CR1), recognised as key players in AD pathology, a...

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Bibliographic Details
Main Authors: Aurora Veteleanu, Joshua Stevenson-Hoare, Samuel Keat, Nikoleta Daskoulidou, Henrik Zetterberg, Amanda Heslegrave, Valentina Escott-Price, Julie Williams, Rebecca Sims, Wioleta M. Zelek, Sarah M. Carpanini, Bryan Paul Morgan
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Complement system
Biomarkers
Clusterin
Complement receptor 1
C1s
Online Access:https://doi.org/10.1186/s12974-023-02850-6

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