Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized Approach
The data regarding the role of progesterone (P4) in reproductive events of endometriosis patients are limited. This prospective study aimed to examine the predictive value of basal P4 serum levels for successful in vitro fertilization (IVF) in patients with primary infertility and endometriosis. The...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/12/10/1639 |
| _version_ | 1797472211864387584 |
|---|---|
| author | Jovan Bila Jelena Dotlic Svetlana Spremovic Radjenovic Snezana Vidakovic Lidija Tulic Jelena Micic Jelena Stojnic Ivana Babovic Aleksandar Dmitrovic Vito Chiantera Antonio Simone Laganà Milan Terzic |
| author_facet | Jovan Bila Jelena Dotlic Svetlana Spremovic Radjenovic Snezana Vidakovic Lidija Tulic Jelena Micic Jelena Stojnic Ivana Babovic Aleksandar Dmitrovic Vito Chiantera Antonio Simone Laganà Milan Terzic |
| author_sort | Jovan Bila |
| collection | DOAJ |
| description | The data regarding the role of progesterone (P4) in reproductive events of endometriosis patients are limited. This prospective study aimed to examine the predictive value of basal P4 serum levels for successful in vitro fertilization (IVF) in patients with primary infertility and endometriosis. The study included 73 patients divided according to endometriosis treatment (surgery vs. control—no treatment). The general data, basal hormonal status, and pregnancy rates were determined for every patient. Clinical pregnancy was achieved in 40.3% of patients, and more often in patients treated for endometriosis before IVF. The regression analysis showed that higher basal P4 serum levels were associated with achieving pregnancy through IVF. When regression was adjusted for the patient and IVF characteristics, higher basal P4 serum levels were associated with pregnancy achievement in both groups of women, along with the basal serum levels of FSH, LH, and AMH; EFI score; and stimulation protocol. The ROC analysis showed that the basal P4 serum level for successful IVF should be ≥0.7ng/mL. The basal P4 serum level cut-off for IVF success in endometriosis patients was determined for the first time. Constructed models for IVF success prediction emphasize the importance of determining the basal P4 serum levels for the personalized treatment of endometriosis-related infertility. |
| first_indexed | 2024-03-09T19:58:55Z |
| format | Article |
| id | doaj.art-59f70a67991d45f6b90171ce0c94df26 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T19:58:55Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-59f70a67991d45f6b90171ce0c94df262023-11-24T00:49:39ZengMDPI AGJournal of Personalized Medicine2075-44262022-10-011210163910.3390/jpm12101639Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized ApproachJovan Bila0Jelena Dotlic1Svetlana Spremovic Radjenovic2Snezana Vidakovic3Lidija Tulic4Jelena Micic5Jelena Stojnic6Ivana Babovic7Aleksandar Dmitrovic8Vito Chiantera9Antonio Simone Laganà10Milan Terzic11Clinic of Obstetrics and Gynecology, University Clinical Centre of Serbia, Dr Koste Todorovica 26, 11000 Belgrade, SerbiaClinic of Obstetrics and Gynecology, University Clinical Centre of Serbia, Dr Koste Todorovica 26, 11000 Belgrade, SerbiaClinic of Obstetrics and Gynecology, University Clinical Centre of Serbia, Dr Koste Todorovica 26, 11000 Belgrade, SerbiaClinic of Obstetrics and Gynecology, University Clinical Centre of Serbia, Dr Koste Todorovica 26, 11000 Belgrade, SerbiaClinic of Obstetrics and Gynecology, University Clinical Centre of Serbia, Dr Koste Todorovica 26, 11000 Belgrade, SerbiaClinic of Obstetrics and Gynecology, University Clinical Centre of Serbia, Dr Koste Todorovica 26, 11000 Belgrade, SerbiaClinic of Obstetrics and Gynecology, University Clinical Centre of Serbia, Dr Koste Todorovica 26, 11000 Belgrade, SerbiaClinic of Obstetrics and Gynecology, University Clinical Centre of Serbia, Dr Koste Todorovica 26, 11000 Belgrade, SerbiaClinic of Obstetrics and Gynecology, University Clinical Centre of Serbia, Dr Koste Todorovica 26, 11000 Belgrade, SerbiaUnit of Gynecologic Oncology, ARNAS “Civico-Di Cristina-Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, ItalyUnit of Gynecologic Oncology, ARNAS “Civico-Di Cristina-Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, ItalyDepartment of Medicine, School of Medicine, Nazarbayev University, Zhanybek-Kerey Khans Street, 5/1, Nur-Sultan 010000, KazakhstanThe data regarding the role of progesterone (P4) in reproductive events of endometriosis patients are limited. This prospective study aimed to examine the predictive value of basal P4 serum levels for successful in vitro fertilization (IVF) in patients with primary infertility and endometriosis. The study included 73 patients divided according to endometriosis treatment (surgery vs. control—no treatment). The general data, basal hormonal status, and pregnancy rates were determined for every patient. Clinical pregnancy was achieved in 40.3% of patients, and more often in patients treated for endometriosis before IVF. The regression analysis showed that higher basal P4 serum levels were associated with achieving pregnancy through IVF. When regression was adjusted for the patient and IVF characteristics, higher basal P4 serum levels were associated with pregnancy achievement in both groups of women, along with the basal serum levels of FSH, LH, and AMH; EFI score; and stimulation protocol. The ROC analysis showed that the basal P4 serum level for successful IVF should be ≥0.7ng/mL. The basal P4 serum level cut-off for IVF success in endometriosis patients was determined for the first time. Constructed models for IVF success prediction emphasize the importance of determining the basal P4 serum levels for the personalized treatment of endometriosis-related infertility.https://www.mdpi.com/2075-4426/12/10/1639progesteroneendometriosissurgeryin vitro fertilizationpersonalized approach |
| spellingShingle | Jovan Bila Jelena Dotlic Svetlana Spremovic Radjenovic Snezana Vidakovic Lidija Tulic Jelena Micic Jelena Stojnic Ivana Babovic Aleksandar Dmitrovic Vito Chiantera Antonio Simone Laganà Milan Terzic Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized Approach Journal of Personalized Medicine progesterone endometriosis surgery in vitro fertilization personalized approach |
| title | Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized Approach |
| title_full | Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized Approach |
| title_fullStr | Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized Approach |
| title_full_unstemmed | Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized Approach |
| title_short | Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized Approach |
| title_sort | predictive value of basal serum progesterone for successful ivf in endometriosis patients the need for a personalized approach |
| topic | progesterone endometriosis surgery in vitro fertilization personalized approach |
| url | https://www.mdpi.com/2075-4426/12/10/1639 |
| work_keys_str_mv | AT jovanbila predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach AT jelenadotlic predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach AT svetlanaspremovicradjenovic predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach AT snezanavidakovic predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach AT lidijatulic predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach AT jelenamicic predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach AT jelenastojnic predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach AT ivanababovic predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach AT aleksandardmitrovic predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach AT vitochiantera predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach AT antoniosimonelagana predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach AT milanterzic predictivevalueofbasalserumprogesteroneforsuccessfulivfinendometriosispatientstheneedforapersonalizedapproach |