Autophagic Regulation of Lipid Homeostasis in Cardiometabolic Syndrome
As an important protein quality control process, autophagy is essential for the degradation and removal of long-lived or injured cellular components and organelles. Autophagy is known to participate in a number of pathophysiological processes including cardiometabolic syndrome. Recent findings have...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-05-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fcvm.2018.00038/full |
| _version_ | 1828782342533021696 |
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| author | Mingjie Yang Yingmei Zhang Jun Ren Jun Ren |
| author_facet | Mingjie Yang Yingmei Zhang Jun Ren Jun Ren |
| author_sort | Mingjie Yang |
| collection | DOAJ |
| description | As an important protein quality control process, autophagy is essential for the degradation and removal of long-lived or injured cellular components and organelles. Autophagy is known to participate in a number of pathophysiological processes including cardiometabolic syndrome. Recent findings have shown compelling evidence for the intricate interplay between autophagy and lipid metabolism. Autophagy serves as a major regulator of lipid homeostasis while lipid can also influence autophagosome formation and autophagic signaling. Lipophagy is a unique form of selective autophagy and functions as a fundamental mechanism for clearance of lipid excess in atherosclerotic plaques. Ample of evidence has denoted a novel therapeutic potential for autophagy in deranged lipid metabolism and management of cardiometabolic diseases such as atherosclerosis and diabetic cardiomyopathy. Here we will review the interplays between cardiac autophagy and lipid metabolism in an effort to seek new therapeutic options for cardiometabolic diseases. |
| first_indexed | 2024-12-11T17:47:09Z |
| format | Article |
| id | doaj.art-59fa0792c2df4c998ebd93e56b9963e5 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-11T17:47:09Z |
| publishDate | 2018-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-59fa0792c2df4c998ebd93e56b9963e52022-12-22T00:56:19ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2018-05-01510.3389/fcvm.2018.00038361308Autophagic Regulation of Lipid Homeostasis in Cardiometabolic SyndromeMingjie YangYingmei ZhangJun RenJun RenAs an important protein quality control process, autophagy is essential for the degradation and removal of long-lived or injured cellular components and organelles. Autophagy is known to participate in a number of pathophysiological processes including cardiometabolic syndrome. Recent findings have shown compelling evidence for the intricate interplay between autophagy and lipid metabolism. Autophagy serves as a major regulator of lipid homeostasis while lipid can also influence autophagosome formation and autophagic signaling. Lipophagy is a unique form of selective autophagy and functions as a fundamental mechanism for clearance of lipid excess in atherosclerotic plaques. Ample of evidence has denoted a novel therapeutic potential for autophagy in deranged lipid metabolism and management of cardiometabolic diseases such as atherosclerosis and diabetic cardiomyopathy. Here we will review the interplays between cardiac autophagy and lipid metabolism in an effort to seek new therapeutic options for cardiometabolic diseases.http://journal.frontiersin.org/article/10.3389/fcvm.2018.00038/fullheartautophagylipid metabolismlipophagycardiometabolic diseases |
| spellingShingle | Mingjie Yang Yingmei Zhang Jun Ren Jun Ren Autophagic Regulation of Lipid Homeostasis in Cardiometabolic Syndrome Frontiers in Cardiovascular Medicine heart autophagy lipid metabolism lipophagy cardiometabolic diseases |
| title | Autophagic Regulation of Lipid Homeostasis in Cardiometabolic Syndrome |
| title_full | Autophagic Regulation of Lipid Homeostasis in Cardiometabolic Syndrome |
| title_fullStr | Autophagic Regulation of Lipid Homeostasis in Cardiometabolic Syndrome |
| title_full_unstemmed | Autophagic Regulation of Lipid Homeostasis in Cardiometabolic Syndrome |
| title_short | Autophagic Regulation of Lipid Homeostasis in Cardiometabolic Syndrome |
| title_sort | autophagic regulation of lipid homeostasis in cardiometabolic syndrome |
| topic | heart autophagy lipid metabolism lipophagy cardiometabolic diseases |
| url | http://journal.frontiersin.org/article/10.3389/fcvm.2018.00038/full |
| work_keys_str_mv | AT mingjieyang autophagicregulationoflipidhomeostasisincardiometabolicsyndrome AT yingmeizhang autophagicregulationoflipidhomeostasisincardiometabolicsyndrome AT junren autophagicregulationoflipidhomeostasisincardiometabolicsyndrome AT junren autophagicregulationoflipidhomeostasisincardiometabolicsyndrome |