Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma
Colon adenocarcinoma (COAD), ranking third in incidence and second in mortality, is one of the most common cancer types in the world. The initial stages of COAD usually show no obvious clinical symptoms; moreover, effective screening or diagnostic indicators with high sensitivity and specificity are...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2022.849771/full |
| _version_ | 1818199819375607808 |
|---|---|
| author | Chen Pang Hongwei Wang Chengcheng Shen Houjie Liang |
| author_facet | Chen Pang Hongwei Wang Chengcheng Shen Houjie Liang |
| author_sort | Chen Pang |
| collection | DOAJ |
| description | Colon adenocarcinoma (COAD), ranking third in incidence and second in mortality, is one of the most common cancer types in the world. The initial stages of COAD usually show no obvious clinical symptoms; moreover, effective screening or diagnostic indicators with high sensitivity and specificity are lacking, which often leads to missed treatment opportunities. Collagen triple helix repeat containing 1 (CTHRC1) is a glycosylated protein secreted during tissue repair, which reduces collagen matrix deposition and promotes cell migration. Under physiological conditions, the expression of CTHRC1 is conducive to wound healing; however, the pathological overexpression of CTHRC1 promotes tumour growth and proliferation. In this study, we evaluated the application potential of CTHRC1 as an early diagnosis and prognostic survival monitoring biomarker for COAD in addition to unravelling its molecular mechanism in the development of COAD and exploring new therapeutic targets. Therefore, various tumour databases were used to investigate the expression of CTHRC1 in COAD at the mRNA and protein levels. CTHRC1 expression was found to be significantly increased in COAD, regardless of clinical cancer stage, age, sex or race. Moreover, CTHRC1 expression was significantly correlated with poor prognosis and positively correlated with CD8+ T cell, CD4+ T cell, neutrophil, macrophage and dendritic cell infiltration. The relevant function pathways and neighbouring proteins to CTHRC1 in COAD were identified as ROR2, VAPA, LY6E and several collagen family proteins. Therefore, this study suggests that CTHRC1 is a potential diagnostic and prognostic biomarker for patients with COAD. |
| first_indexed | 2024-12-12T02:27:49Z |
| format | Article |
| id | doaj.art-59fafdcd67724daab4d2cad16b54bcc0 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-12T02:27:49Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-59fafdcd67724daab4d2cad16b54bcc02022-12-22T00:41:31ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2022-03-01910.3389/fmolb.2022.849771849771Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon AdenocarcinomaChen Pang0Hongwei Wang1Chengcheng Shen2Houjie Liang3Department of Oncology and Southwest Cancer Centre, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Oncology and Southwest Cancer Centre, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Oncology and Southwest Cancer Centre, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaColon adenocarcinoma (COAD), ranking third in incidence and second in mortality, is one of the most common cancer types in the world. The initial stages of COAD usually show no obvious clinical symptoms; moreover, effective screening or diagnostic indicators with high sensitivity and specificity are lacking, which often leads to missed treatment opportunities. Collagen triple helix repeat containing 1 (CTHRC1) is a glycosylated protein secreted during tissue repair, which reduces collagen matrix deposition and promotes cell migration. Under physiological conditions, the expression of CTHRC1 is conducive to wound healing; however, the pathological overexpression of CTHRC1 promotes tumour growth and proliferation. In this study, we evaluated the application potential of CTHRC1 as an early diagnosis and prognostic survival monitoring biomarker for COAD in addition to unravelling its molecular mechanism in the development of COAD and exploring new therapeutic targets. Therefore, various tumour databases were used to investigate the expression of CTHRC1 in COAD at the mRNA and protein levels. CTHRC1 expression was found to be significantly increased in COAD, regardless of clinical cancer stage, age, sex or race. Moreover, CTHRC1 expression was significantly correlated with poor prognosis and positively correlated with CD8+ T cell, CD4+ T cell, neutrophil, macrophage and dendritic cell infiltration. The relevant function pathways and neighbouring proteins to CTHRC1 in COAD were identified as ROR2, VAPA, LY6E and several collagen family proteins. Therefore, this study suggests that CTHRC1 is a potential diagnostic and prognostic biomarker for patients with COAD.https://www.frontiersin.org/articles/10.3389/fmolb.2022.849771/fullcollagen triple helix repeat containing 1 (CTHRC1)colon adenocarcinoma (COAD)diagnosisprognosisimmune infiltrationfunction pathway |
| spellingShingle | Chen Pang Hongwei Wang Chengcheng Shen Houjie Liang Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma Frontiers in Molecular Biosciences collagen triple helix repeat containing 1 (CTHRC1) colon adenocarcinoma (COAD) diagnosis prognosis immune infiltration function pathway |
| title | Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma |
| title_full | Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma |
| title_fullStr | Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma |
| title_full_unstemmed | Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma |
| title_short | Application Potential of CTHRC1 as a Diagnostic and Prognostic Indicator for Colon Adenocarcinoma |
| title_sort | application potential of cthrc1 as a diagnostic and prognostic indicator for colon adenocarcinoma |
| topic | collagen triple helix repeat containing 1 (CTHRC1) colon adenocarcinoma (COAD) diagnosis prognosis immune infiltration function pathway |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2022.849771/full |
| work_keys_str_mv | AT chenpang applicationpotentialofcthrc1asadiagnosticandprognosticindicatorforcolonadenocarcinoma AT hongweiwang applicationpotentialofcthrc1asadiagnosticandprognosticindicatorforcolonadenocarcinoma AT chengchengshen applicationpotentialofcthrc1asadiagnosticandprognosticindicatorforcolonadenocarcinoma AT houjieliang applicationpotentialofcthrc1asadiagnosticandprognosticindicatorforcolonadenocarcinoma |