129 Anatomical Approaches to Treating Obstructive Sleep Apnea in Patients who Fail CPAP: State of the Art Review
OBJECTIVES/GOALS: The aim of this study was to evaluate current and new anatomical approaches to treating obstructive sleep apnea (OSA) in patients who fail continuous positive airway pressure (CPAP). Understanding the breadth of devices and procedures increases clinical scope of practice and innova...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-04-01
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| Series: | Journal of Clinical and Translational Science |
| Online Access: | https://www.cambridge.org/core/product/identifier/S205986612300211X/type/journal_article |
| _version_ | 1797840475329134592 |
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| author | Phoebe Dijour Mitchell Turley Shri Prabha Shivram Anders Sideris Youseph Yazdi |
| author_facet | Phoebe Dijour Mitchell Turley Shri Prabha Shivram Anders Sideris Youseph Yazdi |
| author_sort | Phoebe Dijour |
| collection | DOAJ |
| description | OBJECTIVES/GOALS: The aim of this study was to evaluate current and new anatomical approaches to treating obstructive sleep apnea (OSA) in patients who fail continuous positive airway pressure (CPAP). Understanding the breadth of devices and procedures increases clinical scope of practice and innovator opportunities. METHODS/STUDY POPULATION: A comprehensive review of literature, FDA approvals, patents, and commercially available technologies was undertaken with regards to anatomical approaches for treating OSA. These include experimental therapies, surgical approaches, and non-surgical ablative procedures. Oral appliances, positive airway pressure devices, and therapeutics were excluded. Key search terms included obstructive sleep apnea,’ anatomy,’ surgery,’ devices,’ experimental therapy,’ innovation,’ technology,’ and translational research.’ Publications were limited to the last five years. Innovations were evaluated for relevance to OSA treatment and then assessed in greater depth based on scientific literature. RESULTS/ANTICIPATED RESULTS: Numbers of preclinical and commercially available innovations pertinent to the anatomical treatment of OSA were reported along with clinically relevant outcome metrics. The greatest number of innovations was found in surgical approaches, including soft-tissue removal, orthognathic surgery, and electrical stimulation. Outcome parameters included safety, efficacy, patient compliance, and mean disease alleviation as a ratio of efficacy to compliance. Innovations were grouped by their intended anatomical targets including retrolingual, palatal, oropharyngeal, epiglottic, nasal, and complete concentric collapse, making special note of gaps in the treatment armamentarium. DISCUSSION/SIGNIFICANCE: In the last decade, sleep surgery has trended toward innovative CPAP alternatives. Nerve stimulation and ablative procedures have grown, but some anatomical presentations have been frequently excluded. These developments present opportunities for innovators to fill persistent gaps in treatment. |
| first_indexed | 2024-04-09T16:15:56Z |
| format | Article |
| id | doaj.art-59fb4f12613e4cd2958e254c7a9e8eda |
| institution | Directory Open Access Journal |
| issn | 2059-8661 |
| language | English |
| last_indexed | 2024-04-09T16:15:56Z |
| publishDate | 2023-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Clinical and Translational Science |
| spelling | doaj.art-59fb4f12613e4cd2958e254c7a9e8eda2023-04-24T05:55:54ZengCambridge University PressJournal of Clinical and Translational Science2059-86612023-04-017393910.1017/cts.2023.211129 Anatomical Approaches to Treating Obstructive Sleep Apnea in Patients who Fail CPAP: State of the Art ReviewPhoebe Dijour0Mitchell Turley1Shri Prabha Shivram2Anders Sideris3Youseph Yazdi4Johns Hopkins UniversityJohns Hopkins UniversityJohns Hopkins UniversityJohns Hopkins UniversityJohns Hopkins UniversityOBJECTIVES/GOALS: The aim of this study was to evaluate current and new anatomical approaches to treating obstructive sleep apnea (OSA) in patients who fail continuous positive airway pressure (CPAP). Understanding the breadth of devices and procedures increases clinical scope of practice and innovator opportunities. METHODS/STUDY POPULATION: A comprehensive review of literature, FDA approvals, patents, and commercially available technologies was undertaken with regards to anatomical approaches for treating OSA. These include experimental therapies, surgical approaches, and non-surgical ablative procedures. Oral appliances, positive airway pressure devices, and therapeutics were excluded. Key search terms included obstructive sleep apnea,’ anatomy,’ surgery,’ devices,’ experimental therapy,’ innovation,’ technology,’ and translational research.’ Publications were limited to the last five years. Innovations were evaluated for relevance to OSA treatment and then assessed in greater depth based on scientific literature. RESULTS/ANTICIPATED RESULTS: Numbers of preclinical and commercially available innovations pertinent to the anatomical treatment of OSA were reported along with clinically relevant outcome metrics. The greatest number of innovations was found in surgical approaches, including soft-tissue removal, orthognathic surgery, and electrical stimulation. Outcome parameters included safety, efficacy, patient compliance, and mean disease alleviation as a ratio of efficacy to compliance. Innovations were grouped by their intended anatomical targets including retrolingual, palatal, oropharyngeal, epiglottic, nasal, and complete concentric collapse, making special note of gaps in the treatment armamentarium. DISCUSSION/SIGNIFICANCE: In the last decade, sleep surgery has trended toward innovative CPAP alternatives. Nerve stimulation and ablative procedures have grown, but some anatomical presentations have been frequently excluded. These developments present opportunities for innovators to fill persistent gaps in treatment.https://www.cambridge.org/core/product/identifier/S205986612300211X/type/journal_article |
| spellingShingle | Phoebe Dijour Mitchell Turley Shri Prabha Shivram Anders Sideris Youseph Yazdi 129 Anatomical Approaches to Treating Obstructive Sleep Apnea in Patients who Fail CPAP: State of the Art Review Journal of Clinical and Translational Science |
| title | 129 Anatomical Approaches to Treating Obstructive Sleep Apnea in Patients who Fail CPAP: State of the Art Review |
| title_full | 129 Anatomical Approaches to Treating Obstructive Sleep Apnea in Patients who Fail CPAP: State of the Art Review |
| title_fullStr | 129 Anatomical Approaches to Treating Obstructive Sleep Apnea in Patients who Fail CPAP: State of the Art Review |
| title_full_unstemmed | 129 Anatomical Approaches to Treating Obstructive Sleep Apnea in Patients who Fail CPAP: State of the Art Review |
| title_short | 129 Anatomical Approaches to Treating Obstructive Sleep Apnea in Patients who Fail CPAP: State of the Art Review |
| title_sort | 129 anatomical approaches to treating obstructive sleep apnea in patients who fail cpap state of the art review |
| url | https://www.cambridge.org/core/product/identifier/S205986612300211X/type/journal_article |
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