Expression of substance P, neurokinin 1 receptor, Ki-67 and pyruvate kinase M2 in hormone receptor negative breast cancer and evaluation of impact on overall survival

Expression of substance P, neurokinin 1 receptor, Ki-67 and pyruvate kinase M2 in hormone receptor negative breast cancer and evaluation of impact on overall survival

Abstract Background Chronic inflammation is a hallmark of cancer, and it can be stimulated by many factors. Substance P (SP), through binding to neurokinin 1 receptor (NK1R), and pyruvate kinase M2 (PKM2) play critical roles in cancer development and progression via modulating the tumor microenviron...

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Bibliographic Details
Main Authors: Maha S. Al-Keilani, Roba Bdeir, Rana I. Elstaty, Mohammad A. Alqudah
Format: Article
Language:English
Published: BMC 2023-02-01
Series:BMC Cancer
Subjects:
Substance P
Neurokinin 1 receptor
Pyruvate kinase M2
Ki-67
Breast cancer
Prognosis
Online Access:https://doi.org/10.1186/s12885-023-10633-8

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