Bacterial Profile and Antimicrobial Resistance of Infections Among Hospitalized Burn Patients in Asia: A Systematic Review
Burn injuries cause a considered number of deaths, mainly due to infections. Many low and middle-income countries in Asia lack data on the causes of burn infections and their antimicrobials susceptibility patterns. This systematic review was conducted to analyze Asian studies on the main agents of i...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Salahaddin University-Erbil
2024-02-01
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| Series: | Zanco Journal of Pure and Applied Sciences |
| Subjects: | |
| Online Access: | https://zancojournal.su.edu.krd/index.php/JPAS/article/view/475 |
| _version_ | 1797303239914291200 |
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| author | Zean Zefenkey Salah Mahdi Al-Bader Hama Tellawi |
| author_facet | Zean Zefenkey Salah Mahdi Al-Bader Hama Tellawi |
| author_sort | Zean Zefenkey |
| collection | DOAJ |
| description | Burn injuries cause a considered number of deaths, mainly due to infections. Many low and middle-income countries in Asia lack data on the causes of burn infections and their antimicrobials susceptibility patterns. This systematic review was conducted to analyze Asian studies on the main agents of infection among hospitalized burn patients and their antimicrobials resistance to guide the empirical treatment which is very important for nosocomial infection control.
A literature search was performed in electronic databases to identify related studies between 2013 and 2022. All the finding studies were screened to ensure compliance with including criteria.
After the full screening of the articles, 24 studies were included in this work. The majority of pathogens were gram-negative bacteria (63.5%). The pooled prevalence of isolated bacteria of burn infection revealed that A. baumannii (23.8%), P. aeruginosa (20%), S. aureus (19.7%), and K. pneumoniae (11.5%) were the most frequent. According to the pooled results of Antimicrobial Susceptibility Testing (AST) of the included studies, most strains of isolated bacteria were multidrug-resistant (MDR). For gram-negative bacteria, the susceptibility pattern varies greatly according to the genus. The levofloxacin is the only common effective antimicrobial in different percentages. Methicillin-resistant Staphylococcus aureus (MRSA) accounted for 70.4% of the isolated S. aureus. Vancomycin and linezolid have a high susceptibility for all gram-positive cocci.
This review suggests that the empirical therapy of hospitalized burn patients in Asia should depend on the combination of antimicrobials that include levofloxacin to prevent increasing MDR emergence in the future. Further studies should be conducted to confirm the clinical effect of these procedures. |
| first_indexed | 2024-03-07T23:50:01Z |
| format | Article |
| id | doaj.art-59fed8762cd842c18ab467afe4f09af7 |
| institution | Directory Open Access Journal |
| issn | 2218-0230 2412-3986 |
| language | English |
| last_indexed | 2024-03-07T23:50:01Z |
| publishDate | 2024-02-01 |
| publisher | Salahaddin University-Erbil |
| record_format | Article |
| series | Zanco Journal of Pure and Applied Sciences |
| spelling | doaj.art-59fed8762cd842c18ab467afe4f09af72024-02-19T08:29:19ZengSalahaddin University-ErbilZanco Journal of Pure and Applied Sciences2218-02302412-39862024-02-0136110.21271/ZJPAS.36.1.2Bacterial Profile and Antimicrobial Resistance of Infections Among Hospitalized Burn Patients in Asia: A Systematic ReviewZean ZefenkeySalah Mahdi Al-BaderHama TellawiBurn injuries cause a considered number of deaths, mainly due to infections. Many low and middle-income countries in Asia lack data on the causes of burn infections and their antimicrobials susceptibility patterns. This systematic review was conducted to analyze Asian studies on the main agents of infection among hospitalized burn patients and their antimicrobials resistance to guide the empirical treatment which is very important for nosocomial infection control. A literature search was performed in electronic databases to identify related studies between 2013 and 2022. All the finding studies were screened to ensure compliance with including criteria. After the full screening of the articles, 24 studies were included in this work. The majority of pathogens were gram-negative bacteria (63.5%). The pooled prevalence of isolated bacteria of burn infection revealed that A. baumannii (23.8%), P. aeruginosa (20%), S. aureus (19.7%), and K. pneumoniae (11.5%) were the most frequent. According to the pooled results of Antimicrobial Susceptibility Testing (AST) of the included studies, most strains of isolated bacteria were multidrug-resistant (MDR). For gram-negative bacteria, the susceptibility pattern varies greatly according to the genus. The levofloxacin is the only common effective antimicrobial in different percentages. Methicillin-resistant Staphylococcus aureus (MRSA) accounted for 70.4% of the isolated S. aureus. Vancomycin and linezolid have a high susceptibility for all gram-positive cocci. This review suggests that the empirical therapy of hospitalized burn patients in Asia should depend on the combination of antimicrobials that include levofloxacin to prevent increasing MDR emergence in the future. Further studies should be conducted to confirm the clinical effect of these procedures.https://zancojournal.su.edu.krd/index.php/JPAS/article/view/475nosocomial infectionsmultidrug resistanceempirical therapya. baumanniip. aeruginosas. aureus. |
| spellingShingle | Zean Zefenkey Salah Mahdi Al-Bader Hama Tellawi Bacterial Profile and Antimicrobial Resistance of Infections Among Hospitalized Burn Patients in Asia: A Systematic Review Zanco Journal of Pure and Applied Sciences nosocomial infections multidrug resistance empirical therapy a. baumannii p. aeruginosa s. aureus. |
| title | Bacterial Profile and Antimicrobial Resistance of Infections Among Hospitalized Burn Patients in Asia: A Systematic Review |
| title_full | Bacterial Profile and Antimicrobial Resistance of Infections Among Hospitalized Burn Patients in Asia: A Systematic Review |
| title_fullStr | Bacterial Profile and Antimicrobial Resistance of Infections Among Hospitalized Burn Patients in Asia: A Systematic Review |
| title_full_unstemmed | Bacterial Profile and Antimicrobial Resistance of Infections Among Hospitalized Burn Patients in Asia: A Systematic Review |
| title_short | Bacterial Profile and Antimicrobial Resistance of Infections Among Hospitalized Burn Patients in Asia: A Systematic Review |
| title_sort | bacterial profile and antimicrobial resistance of infections among hospitalized burn patients in asia a systematic review |
| topic | nosocomial infections multidrug resistance empirical therapy a. baumannii p. aeruginosa s. aureus. |
| url | https://zancojournal.su.edu.krd/index.php/JPAS/article/view/475 |
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