DDHD1, but Not DDHD2, Suppresses Neurite Outgrowth in SH-SY5Y and PC12 Cells by Regulating Protein Transport From Recycling Endosomes

DDHD1, but Not DDHD2, Suppresses Neurite Outgrowth in SH-SY5Y and PC12 Cells by Regulating Protein Transport From Recycling Endosomes

DDHD1 and DDHD2 are both intracellular phospholipases A1 and hydrolyze phosphatidic acid in vitro. Given that phosphatidic acid participates in neurite outgrowth, we examined whether DDHD1 and DDHD2 regulate neurite outgrowth. Depletion of DDHD1 from SH-SY5Y and PC12 cells caused elongation of neuri...

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Bibliographic Details
Main Authors: Yuki Maemoto, Tomohiro Maruyama, Kazuaki Nemoto, Takashi Baba, Manae Motohashi, Akihiro Ito, Mitsuo Tagaya, Katsuko Tani
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
endosome
phospholipase
neurite
phosphatidic acid
recycling
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00670/full

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