Human skeletal myopathy myosin mutations disrupt myosin head sequestration

Human skeletal myopathy myosin mutations disrupt myosin head sequestration

Myosin heavy chains encoded by MYH7 and MYH2 are abundant in human skeletal muscle and important for muscle contraction. However, it is unclear how mutations in these genes disrupt myosin structure and function leading to skeletal muscle myopathies termed myosinopathies. Here, we used multiple appro...

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Xehetasun bibliografikoak
Egile Nagusiak: Glenn Carrington, Abbi Hau, Sarah Kosta, Hannah F. Dugdale, Francesco Muntoni, Adele D’Amico, Peter Van den Bergh, Norma B. Romero, Edoardo Malfatti, Juan Jesus Vilchez, Anders Oldfors, Sander Pajusalu, Katrin Õunap, Marta Giralt-Pujol, Edmar Zanoteli, Kenneth S. Campbell, Hiroyuki Iwamoto, Michelle Peckham, Julien Ochala
Formatua: Artikulua
Hizkuntza:English
Argitaratua: American Society for Clinical investigation 2023-11-01
Saila:JCI Insight
Gaiak:
Muscle biology
Sarrera elektronikoa:https://doi.org/10.1172/jci.insight.172322

Internet

https://doi.org/10.1172/jci.insight.172322

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