The Role of Wnt Signalling in Chronic Kidney Disease (CKD)
Chronic kidney disease (CKD) encompasses a group of diverse diseases that are associated with accumulating kidney damage and a decline in glomerular filtration rate (GFR). These conditions can be of an acquired or genetic nature and, in many cases, interactions between genetics and the environment a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/11/5/496 |
| _version_ | 1797569193267167232 |
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| author | Soniya A. Malik Kavindiya Modarage Paraskevi Goggolidou |
| author_facet | Soniya A. Malik Kavindiya Modarage Paraskevi Goggolidou |
| author_sort | Soniya A. Malik |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) encompasses a group of diverse diseases that are associated with accumulating kidney damage and a decline in glomerular filtration rate (GFR). These conditions can be of an acquired or genetic nature and, in many cases, interactions between genetics and the environment also play a role in disease manifestation and severity. In this review, we focus on genetically inherited chronic kidney diseases and dissect the links between canonical and non-canonical Wnt signalling, and this umbrella of conditions that result in kidney damage. Most of the current evidence on the role of Wnt signalling in CKD is gathered from studies in polycystic kidney disease (PKD) and nephronophthisis (NPHP) and reveals the involvement of β-catenin. Nevertheless, recent findings have also linked planar cell polarity (PCP) signalling to CKD, with further studies being required to fully understand the links and molecular mechanisms. |
| first_indexed | 2024-03-10T20:07:24Z |
| format | Article |
| id | doaj.art-5a02f1fcd45d4110848c5b65c6baa74c |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T20:07:24Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-5a02f1fcd45d4110848c5b65c6baa74c2023-11-19T23:10:32ZengMDPI AGGenes2073-44252020-04-0111549610.3390/genes11050496The Role of Wnt Signalling in Chronic Kidney Disease (CKD)Soniya A. Malik0Kavindiya Modarage1Paraskevi Goggolidou2Department of Biomedical Science and Physiology, Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1LY, UKDepartment of Biomedical Science and Physiology, Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1LY, UKDepartment of Biomedical Science and Physiology, Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1LY, UKChronic kidney disease (CKD) encompasses a group of diverse diseases that are associated with accumulating kidney damage and a decline in glomerular filtration rate (GFR). These conditions can be of an acquired or genetic nature and, in many cases, interactions between genetics and the environment also play a role in disease manifestation and severity. In this review, we focus on genetically inherited chronic kidney diseases and dissect the links between canonical and non-canonical Wnt signalling, and this umbrella of conditions that result in kidney damage. Most of the current evidence on the role of Wnt signalling in CKD is gathered from studies in polycystic kidney disease (PKD) and nephronophthisis (NPHP) and reveals the involvement of β-catenin. Nevertheless, recent findings have also linked planar cell polarity (PCP) signalling to CKD, with further studies being required to fully understand the links and molecular mechanisms.https://www.mdpi.com/2073-4425/11/5/496Wnt signallingpolycystic kidney diseasenephronophthisisbeta-cateninplanar cell polarity signalling |
| spellingShingle | Soniya A. Malik Kavindiya Modarage Paraskevi Goggolidou The Role of Wnt Signalling in Chronic Kidney Disease (CKD) Genes Wnt signalling polycystic kidney disease nephronophthisis beta-catenin planar cell polarity signalling |
| title | The Role of Wnt Signalling in Chronic Kidney Disease (CKD) |
| title_full | The Role of Wnt Signalling in Chronic Kidney Disease (CKD) |
| title_fullStr | The Role of Wnt Signalling in Chronic Kidney Disease (CKD) |
| title_full_unstemmed | The Role of Wnt Signalling in Chronic Kidney Disease (CKD) |
| title_short | The Role of Wnt Signalling in Chronic Kidney Disease (CKD) |
| title_sort | role of wnt signalling in chronic kidney disease ckd |
| topic | Wnt signalling polycystic kidney disease nephronophthisis beta-catenin planar cell polarity signalling |
| url | https://www.mdpi.com/2073-4425/11/5/496 |
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