<i>IL1B</i> Polymorphism (rs1143634) and IL-1β Plasma Concentration as Predictors of Nutritional Disorders and Prognostic Factors in Multiple Myeloma Patients
Background: Multiple myeloma (MM) is a hematological neoplasm of the early precursor of B-cells. The most characteristic symptoms observed during MM include hypocalcemia, anemia, bacterial infections, and renal damage. Nutritional disorders, especially malnutrition, are noted in about 35–71% of MM p...
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MDPI AG
2024-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/7/1263 |
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| author | Marcin Mazurek Aneta Szudy-Szczyrek Iwona Homa-Mlak Marek Hus Teresa Małecka-Massalska Radosław Mlak |
| author_facet | Marcin Mazurek Aneta Szudy-Szczyrek Iwona Homa-Mlak Marek Hus Teresa Małecka-Massalska Radosław Mlak |
| author_sort | Marcin Mazurek |
| collection | DOAJ |
| description | Background: Multiple myeloma (MM) is a hematological neoplasm of the early precursor of B-cells. The most characteristic symptoms observed during MM include hypocalcemia, anemia, bacterial infections, and renal damage. Nutritional disorders, especially malnutrition, are noted in about 35–71% of MM patients. Interleukin 1 beta (IL-1β) is a proinflammatory cytokine responsible for muscle atrophy and lipolysis during malnutrition and cachexia. This study aimed to evaluate the usefulness of the <i>IL1B</i> single-nucleotide polymorphism (SNP) (rs1143634) and plasma concentration of IL-1β in the assessment of the risk of nutritional disorders and prognosis in patients with MM. Methods: In our study, 93 patients with the de novo MM were enrolled. The real-time PCR with specific TaqMan probes method was used in genotyping. The IL-1β ELISA kit was used to determine IL-1β concentration in plasma samples. Results: Patients with the CC genotype, compared to the carriers of the other variants of the <i>IL1B</i>, demonstrated significantly higher concentrations of IL-1β in plasma (7.56 vs. 4.97 pg/mL), a significantly higher risk of cachexia (OR = 5.11), and a significantly higher risk of death (HR = 2.03). Moreover, high IL-1β plasma level was related to a significantly higher risk of cachexia (OR = 7.76); however, it was not significantly associated with progression-free survival (PFS) or overall survival (OS). Conclusions: Determination of the <i>IL1B</i> SNP (rs1143634) and plasma concentration of IL-1β may be useful in the assessment of the risk of cachexia and prognosis in patients with MM. |
| first_indexed | 2024-04-24T10:48:52Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-04-24T10:48:52Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5a03d2e5fc744ce192b3748651ae0a222024-04-12T13:15:52ZengMDPI AGCancers2072-66942024-03-01167126310.3390/cancers16071263<i>IL1B</i> Polymorphism (rs1143634) and IL-1β Plasma Concentration as Predictors of Nutritional Disorders and Prognostic Factors in Multiple Myeloma PatientsMarcin Mazurek0Aneta Szudy-Szczyrek1Iwona Homa-Mlak2Marek Hus3Teresa Małecka-Massalska4Radosław Mlak5Department of Human Physiology of Chair of Preclinical Sciences, Medical University of Lublin, 20-080 Lublin, PolandDepartment of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-080 Lublin, PolandDepartment of Human Physiology of Chair of Preclinical Sciences, Medical University of Lublin, 20-080 Lublin, PolandDepartment of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-080 Lublin, PolandDepartment of Human Physiology of Chair of Preclinical Sciences, Medical University of Lublin, 20-080 Lublin, PolandDepartment of Laboratory Diagnostics, Medical University of Lublin, 20-080 Lublin, PolandBackground: Multiple myeloma (MM) is a hematological neoplasm of the early precursor of B-cells. The most characteristic symptoms observed during MM include hypocalcemia, anemia, bacterial infections, and renal damage. Nutritional disorders, especially malnutrition, are noted in about 35–71% of MM patients. Interleukin 1 beta (IL-1β) is a proinflammatory cytokine responsible for muscle atrophy and lipolysis during malnutrition and cachexia. This study aimed to evaluate the usefulness of the <i>IL1B</i> single-nucleotide polymorphism (SNP) (rs1143634) and plasma concentration of IL-1β in the assessment of the risk of nutritional disorders and prognosis in patients with MM. Methods: In our study, 93 patients with the de novo MM were enrolled. The real-time PCR with specific TaqMan probes method was used in genotyping. The IL-1β ELISA kit was used to determine IL-1β concentration in plasma samples. Results: Patients with the CC genotype, compared to the carriers of the other variants of the <i>IL1B</i>, demonstrated significantly higher concentrations of IL-1β in plasma (7.56 vs. 4.97 pg/mL), a significantly higher risk of cachexia (OR = 5.11), and a significantly higher risk of death (HR = 2.03). Moreover, high IL-1β plasma level was related to a significantly higher risk of cachexia (OR = 7.76); however, it was not significantly associated with progression-free survival (PFS) or overall survival (OS). Conclusions: Determination of the <i>IL1B</i> SNP (rs1143634) and plasma concentration of IL-1β may be useful in the assessment of the risk of cachexia and prognosis in patients with MM.https://www.mdpi.com/2072-6694/16/7/1263multiple myelomacancer cachexiamalnutritioninterleukin 1 betasingle-nucleotide polymorphism |
| spellingShingle | Marcin Mazurek Aneta Szudy-Szczyrek Iwona Homa-Mlak Marek Hus Teresa Małecka-Massalska Radosław Mlak <i>IL1B</i> Polymorphism (rs1143634) and IL-1β Plasma Concentration as Predictors of Nutritional Disorders and Prognostic Factors in Multiple Myeloma Patients Cancers multiple myeloma cancer cachexia malnutrition interleukin 1 beta single-nucleotide polymorphism |
| title | <i>IL1B</i> Polymorphism (rs1143634) and IL-1β Plasma Concentration as Predictors of Nutritional Disorders and Prognostic Factors in Multiple Myeloma Patients |
| title_full | <i>IL1B</i> Polymorphism (rs1143634) and IL-1β Plasma Concentration as Predictors of Nutritional Disorders and Prognostic Factors in Multiple Myeloma Patients |
| title_fullStr | <i>IL1B</i> Polymorphism (rs1143634) and IL-1β Plasma Concentration as Predictors of Nutritional Disorders and Prognostic Factors in Multiple Myeloma Patients |
| title_full_unstemmed | <i>IL1B</i> Polymorphism (rs1143634) and IL-1β Plasma Concentration as Predictors of Nutritional Disorders and Prognostic Factors in Multiple Myeloma Patients |
| title_short | <i>IL1B</i> Polymorphism (rs1143634) and IL-1β Plasma Concentration as Predictors of Nutritional Disorders and Prognostic Factors in Multiple Myeloma Patients |
| title_sort | i il1b i polymorphism rs1143634 and il 1β plasma concentration as predictors of nutritional disorders and prognostic factors in multiple myeloma patients |
| topic | multiple myeloma cancer cachexia malnutrition interleukin 1 beta single-nucleotide polymorphism |
| url | https://www.mdpi.com/2072-6694/16/7/1263 |
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