Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report
Abstract Background Adenoid cystic carcinoma of the trachea is a rare tumor, characterized by slow growth and low rate of local and distant metastasis. When achievable, complete surgical resection represents the optimal treatment approach, with the highest results in terms of overall survival. Radia...
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13256-019-1996-9 |
| _version_ | 1830358754205368320 |
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| author | Gian Paolo Spinelli Evelina Miele Alessandra Anna Prete Giuseppe Lo Russo Alessandro Di Marzo Claudio Di Cristofano Silverio Tomao |
| author_facet | Gian Paolo Spinelli Evelina Miele Alessandra Anna Prete Giuseppe Lo Russo Alessandro Di Marzo Claudio Di Cristofano Silverio Tomao |
| author_sort | Gian Paolo Spinelli |
| collection | DOAJ |
| description | Abstract Background Adenoid cystic carcinoma of the trachea is a rare tumor, characterized by slow growth and low rate of local and distant metastasis. When achievable, complete surgical resection represents the optimal treatment approach, with the highest results in terms of overall survival. Radiation therapy is a reasonable alternative in cases of inoperable disease. Case presentation We report a case of an 82-year-old white man affected by primary adenoid cystic carcinoma of the trachea, treated with debulking surgery and radiotherapy on the residual disease. A three-dimensional conformal radiation therapy was conducted. The total dose amounted to 70 Gy, administered in 35 fractions of 2 Gy. The medium doses given to the esophagus and lungs were 23 Gy and 4.2 Gy respectively. The maximum dose delivered to the spinal cord was 31 Gy with satisfactory results in terms of local control of the disease. Conclusion A combined approach of surgical resection followed by radiotherapy on the residual disease provided an excellent result in terms of disease control, quality of life, and overall survival in a patient with locally advanced tracheal adenoid cystic carcinoma. |
| first_indexed | 2024-12-20T02:47:17Z |
| format | Article |
| id | doaj.art-5a04f256048c48aa86e4351b538521a9 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-20T02:47:17Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-5a04f256048c48aa86e4351b538521a92022-12-21T19:56:08ZengBMCJournal of Medical Case Reports1752-19472019-03-011311510.1186/s13256-019-1996-9Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case reportGian Paolo Spinelli0Evelina Miele1Alessandra Anna Prete2Giuseppe Lo Russo3Alessandro Di Marzo4Claudio Di Cristofano5Silverio Tomao6UOC of Oncology – ASL Latina – Distretto 1, University of Rome “Sapienza”Department of Hematology/Oncology and Stem Cell Transplantation, Bambino Gesù Children’s Hospital, IRCCSUOC of Oncology – ASL Latina – Distretto 1, University of Rome “Sapienza”UOC of Oncology – ASL Latina – Distretto 1, University of Rome “Sapienza”Radiotherapy Unit, Santa Maria Goretti Hospital, ASLUOC of Pathology, Department of Medical-Surgical Sciences and Bio-Technologies, University of Rome “Sapienza”, Polo Pontino, I.C.O.T.UOC of Oncology – ASL Latina – Distretto 1, University of Rome “Sapienza”Abstract Background Adenoid cystic carcinoma of the trachea is a rare tumor, characterized by slow growth and low rate of local and distant metastasis. When achievable, complete surgical resection represents the optimal treatment approach, with the highest results in terms of overall survival. Radiation therapy is a reasonable alternative in cases of inoperable disease. Case presentation We report a case of an 82-year-old white man affected by primary adenoid cystic carcinoma of the trachea, treated with debulking surgery and radiotherapy on the residual disease. A three-dimensional conformal radiation therapy was conducted. The total dose amounted to 70 Gy, administered in 35 fractions of 2 Gy. The medium doses given to the esophagus and lungs were 23 Gy and 4.2 Gy respectively. The maximum dose delivered to the spinal cord was 31 Gy with satisfactory results in terms of local control of the disease. Conclusion A combined approach of surgical resection followed by radiotherapy on the residual disease provided an excellent result in terms of disease control, quality of life, and overall survival in a patient with locally advanced tracheal adenoid cystic carcinoma.http://link.springer.com/article/10.1186/s13256-019-1996-9Adenoid cystic carcinoma (ACC)TracheaRadiotherapySurgery |
| spellingShingle | Gian Paolo Spinelli Evelina Miele Alessandra Anna Prete Giuseppe Lo Russo Alessandro Di Marzo Claudio Di Cristofano Silverio Tomao Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report Journal of Medical Case Reports Adenoid cystic carcinoma (ACC) Trachea Radiotherapy Surgery |
| title | Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report |
| title_full | Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report |
| title_fullStr | Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report |
| title_full_unstemmed | Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report |
| title_short | Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report |
| title_sort | combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma a case report |
| topic | Adenoid cystic carcinoma (ACC) Trachea Radiotherapy Surgery |
| url | http://link.springer.com/article/10.1186/s13256-019-1996-9 |
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