Mn-Based MRI Contrast Agents: An Overview
MRI contrast agents are required in the clinic to detect some pathologies, such as cancers. Nevertheless, at the moment, only small extracellular and non-specific gadolinium complexes are available for clinicians. Moreover, safety issues have recently emerged concerning the use of gadolinium complex...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/21/7275 |
| _version_ | 1797631561067134976 |
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| author | Céline Henoumont Marie Devreux Sophie Laurent |
| author_facet | Céline Henoumont Marie Devreux Sophie Laurent |
| author_sort | Céline Henoumont |
| collection | DOAJ |
| description | MRI contrast agents are required in the clinic to detect some pathologies, such as cancers. Nevertheless, at the moment, only small extracellular and non-specific gadolinium complexes are available for clinicians. Moreover, safety issues have recently emerged concerning the use of gadolinium complexes; hence, alternatives are urgently needed. Manganese-based MRI contrast agents could be one of these alternatives and increasing numbers of studies are available in the literature. This review aims at synthesizing all the research, from small Mn complexes to nanoparticular agents, including theranostic agents, to highlight all the efforts already made by the scientific community to obtain highly efficient agents but also evidence of the weaknesses of the developed systems. |
| first_indexed | 2024-03-11T11:25:18Z |
| format | Article |
| id | doaj.art-5a06296869d04d59b0de4d10650d84dc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T11:25:18Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5a06296869d04d59b0de4d10650d84dc2023-11-10T15:08:27ZengMDPI AGMolecules1420-30492023-10-012821727510.3390/molecules28217275Mn-Based MRI Contrast Agents: An OverviewCéline Henoumont0Marie Devreux1Sophie Laurent2NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, University of Mons, 19 Avenue Maistriau, 7000 Mons, BelgiumNMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, University of Mons, 19 Avenue Maistriau, 7000 Mons, BelgiumNMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, University of Mons, 19 Avenue Maistriau, 7000 Mons, BelgiumMRI contrast agents are required in the clinic to detect some pathologies, such as cancers. Nevertheless, at the moment, only small extracellular and non-specific gadolinium complexes are available for clinicians. Moreover, safety issues have recently emerged concerning the use of gadolinium complexes; hence, alternatives are urgently needed. Manganese-based MRI contrast agents could be one of these alternatives and increasing numbers of studies are available in the literature. This review aims at synthesizing all the research, from small Mn complexes to nanoparticular agents, including theranostic agents, to highlight all the efforts already made by the scientific community to obtain highly efficient agents but also evidence of the weaknesses of the developed systems.https://www.mdpi.com/1420-3049/28/21/7275Mn complexesMn-based nanoparticlestheranosticmagnetic resonance imaging |
| spellingShingle | Céline Henoumont Marie Devreux Sophie Laurent Mn-Based MRI Contrast Agents: An Overview Molecules Mn complexes Mn-based nanoparticles theranostic magnetic resonance imaging |
| title | Mn-Based MRI Contrast Agents: An Overview |
| title_full | Mn-Based MRI Contrast Agents: An Overview |
| title_fullStr | Mn-Based MRI Contrast Agents: An Overview |
| title_full_unstemmed | Mn-Based MRI Contrast Agents: An Overview |
| title_short | Mn-Based MRI Contrast Agents: An Overview |
| title_sort | mn based mri contrast agents an overview |
| topic | Mn complexes Mn-based nanoparticles theranostic magnetic resonance imaging |
| url | https://www.mdpi.com/1420-3049/28/21/7275 |
| work_keys_str_mv | AT celinehenoumont mnbasedmricontrastagentsanoverview AT mariedevreux mnbasedmricontrastagentsanoverview AT sophielaurent mnbasedmricontrastagentsanoverview |