Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA

Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA

Upon the discovery of RNA interference (RNAi), canonical small interfering RNA (siRNA) has been recognized to trigger sequence-specific gene silencing. Despite the benefits of siRNAs as potential new drugs, there are obstacles still to be overcome, including off-target effects and immune stimulation...

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Bibliographic Details
Main Authors:	Maria Abdul Ghafoor Raja, Haliza Katas, Muhammad Wahab Amjad
Format:	Article
Language:	English
Published:	Elsevier 2019-09-01
Series:	Asian Journal of Pharmaceutical Sciences
Online Access:	http://www.sciencedirect.com/science/article/pii/S1818087618306330

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