CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene <i>setd5</i> Leads to Social Impairments in Zebrafish

CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene <i>setd5</i> Leads to Social Impairments in Zebrafish

Haploinsufficiency of the <i>SETD5</i> gene, encoding a SET domain-containing histone methyltransferase, has been identified as a cause of intellectual disability and Autism Spectrum Disorder (ASD). Recently, the zebrafish has emerged as a valuable model to study neurodevelopmental disor...

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Bibliographic Details
Main Authors: Chiara Gabellini, Cecilia Pucci, Chiara De Cesari, Davide Martini, Caterina Di Lauro, Matteo Digregorio, William Norton, Alessio Zippo, Alessandro Sessa, Vania Broccoli, Massimiliano Andreazzoli
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
<i>setd5</i>
zebrafish
autism
neurodevelopment
behavior
Online Access:https://www.mdpi.com/1422-0067/24/1/167

Internet

https://www.mdpi.com/1422-0067/24/1/167

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