Analysis and Interpretation of the Impact of Missense Variants in Cancer

Analysis and Interpretation of the Impact of Missense Variants in Cancer

Large scale genome sequencing allowed the identification of a massive number of genetic variations, whose impact on human health is still unknown. In this review we analyze, by an in silico-based strategy, the impact of missense variants on cancer-related genes, whose effect on protein stability and...

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Bibliographic Details
Main Authors:	Maria Petrosino, Leonore Novak, Alessandra Pasquo, Roberta Chiaraluce, Paola Turina, Emidio Capriotti, Valerio Consalvi
Format:	Article
Language:	English
Published:	MDPI AG 2021-05-01
Series:	International Journal of Molecular Sciences
Subjects:	protein structure protein stability protein function single amino acid variant putative cancer driving variant free-energy change
Online Access:	https://www.mdpi.com/1422-0067/22/11/5416

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