群多普利对大鼠脑缺血再灌注损伤的保护作用研究 Neuroprotective Effects of Trandolapril on Rat Cerebral Ischemia-reperfusion Injury
目的 观察群多普利对大鼠局灶性脑缺血损伤的保护作用,并探究其可能作用机制。 方法 采用改良ZeaLonga's法制作大脑中动脉闭塞(middle c erebral a rtery o cclusion,MCAO)模型。将 健康雄性SD大鼠随机分成假手术组、模型组、群多普利低剂量组(5 mg/kg)、群多普利高剂量组 (10 mg/kg)等四组,观察各实验组大鼠神经功能评分、脑梗死体积、脑组织白细胞介素(i nterl euki n, IL)-1β及IL-10含量变化。 结果 与假手术相比,模型组神经功能缺损程度评分显著提高,脑组织IL-1β及IL-10含量显著增加 (P<0.05)...
Main Author: | 周刚,王佳君 |
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Format: | Article |
Language: | zho |
Published: |
Editorial Department of Chinese Journal of Stroke
2018-04-01
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Series: | Zhongguo cuzhong zazhi |
Subjects: | |
Online Access: | http://www.chinastroke.org.cn/CN/article/openArticlePDF.jsp?id=2451 |
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