The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver

The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver

ING5 is a component of KAT6A and KAT7 histone lysine acetylation protein complexes. ING5 contains a PHD domain that binds to histone H3 lysine 4 when it is trimethylated, and so functions as a ‘reader’ and adaptor protein. KAT6A and KAT7 function are critical for normal hematopoiesis. To examine the...

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Bibliographic Details
Main Authors: Sophia Y.Y. Mah, Hannah K. Vanyai, Yuqing Yang, Anne K. Voss, Tim Thomas
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
ING5
chromatin
KAT6A
KAT7
fetal
hematopoiesis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1119750/full

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