Hyperphosphorylation of hepatic proteome characterizes nonalcoholic fatty liver disease in S-adenosylmethionine deficiency

Hyperphosphorylation of hepatic proteome characterizes nonalcoholic fatty liver disease in S-adenosylmethionine deficiency

Summary: Methionine adenosyltransferase 1a (MAT1A) is responsible for hepatic S-adenosyl-L-methionine (SAMe) biosynthesis. Mat1a−/− mice have hepatic SAMe depletion, develop nonalcoholic steatohepatitis (NASH) which is reversed with SAMe administration. We examined temporal alterations in the proteo...

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Main Authors: Aaron E. Robinson, Aleksandra Binek, Komal Ramani, Niveda Sundararaman, Lucía Barbier-Torres, Ben Murray, Vidya Venkatraman, Simion Kreimer, Angela Mc Ardle, Mazen Noureddin, David Fernández-Ramos, Fernando Lopitz-Otsoa, Virginia Gutiérrez de Juan, Oscar Millet, José M. Mato, Shelly C. Lu, Jennifer E. Van Eyk
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:iScience
Subjects:
Human metabolism
Molecular biology
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223000640

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