Prognostic Value of the CHADS2 Score for Adverse Cardiovascular Events in Coronary Artery Disease Patients Without Atrial Fibrillation—A Multi‐Center Observational Cohort Study
BackgroundThe CHADS2 score has mainly been used to predict the likelihood of cerebrovascular accidents in patients with atrial fibrillation. However, increasing attention is being paid to this scoring system for risk stratification of patients with coronary artery disease. We investigated the value...
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Wiley
2017-08-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.117.006355 |
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| author | Noriaki Tabata Eiichiro Yamamoto Seiji Hokimoto Takayoshi Yamashita Daisuke Sueta Seiji Takashio Yuichiro Arima Yasuhiro Izumiya Sunao Kojima Koichi Kaikita Kunihiko Matsui Kazuteru Fujimoto Kenji Sakamoto Hideki Shimomura Ryusuke Tsunoda Toyoki Hirose Natsuki Nakamura Naritsugu Sakaino Shinichi Nakamura Nobuyasu Yamamoto Toshiyuki Matsumura Ichiro Kajiwara Shunichi Koide Tomohiro Sakamoto Koichi Nakao Shuichi Oshima Kenichi Tsujita |
| author_facet | Noriaki Tabata Eiichiro Yamamoto Seiji Hokimoto Takayoshi Yamashita Daisuke Sueta Seiji Takashio Yuichiro Arima Yasuhiro Izumiya Sunao Kojima Koichi Kaikita Kunihiko Matsui Kazuteru Fujimoto Kenji Sakamoto Hideki Shimomura Ryusuke Tsunoda Toyoki Hirose Natsuki Nakamura Naritsugu Sakaino Shinichi Nakamura Nobuyasu Yamamoto Toshiyuki Matsumura Ichiro Kajiwara Shunichi Koide Tomohiro Sakamoto Koichi Nakao Shuichi Oshima Kenichi Tsujita |
| author_sort | Noriaki Tabata |
| collection | DOAJ |
| description | BackgroundThe CHADS2 score has mainly been used to predict the likelihood of cerebrovascular accidents in patients with atrial fibrillation. However, increasing attention is being paid to this scoring system for risk stratification of patients with coronary artery disease. We investigated the value of the CHADS2 score in predicting cardiovascular/cerebrovascular events in coronary artery disease patients without atrial fibrillation. Methods and ResultsThis was a multicenter, observational cohort study. The subjects had been admitted to one of the participating institutions with coronary artery disease requiring percutaneous coronary intervention. We calculated the CHADS2 scores for 7082 patients (mean age, 69.7 years; males, 71.9%) without clinical evidence of atrial fibrillation. Subjects were subdivided into low‐ (0–1), intermediate‐ (2–3), and high‐score (4–6) groups and followed for 1 year. The end point was a composite of cardiovascular/cerebrovascular death, nonfatal myocardial infarction, and ischemic stroke at 1‐year follow‐up. Rates of triple‐vessel/left main trunk disease correlated positively with CHADS2 score categories. CHADS2 scores among single, double, and triple‐vessel/left main trunk groups were 2 (1–2), 2 (1–3), and 2 (2–3), respectively (P<0.001). A total of 194 patients (2.8%) had a cardiovascular/cerebrovascular event, and Kaplan–Meier analysis demonstrated a significantly higher probability of cardiovascular/cerebrovascular events in proportion to a higher CHADS2 score (log‐rank test, P<0.001). Multivariate Cox hazard analysis identified CHADS2 score (per 1 point) as an independent predictor of cardiovascular/cerebrovascular events (hazard ratio, 1.31; 95% CI, 1.17–1.47; P<0.001). ConclusionsThis large cohort study indicated that the CHADS2 score is useful for the prediction of cardiovascular/cerebrovascular events in coronary artery disease patients without atrial fibrillation. |
| first_indexed | 2024-12-18T10:50:48Z |
| format | Article |
| id | doaj.art-5a0e4a2860fd496ca66f6eff41dfd023 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-18T10:50:48Z |
| publishDate | 2017-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-5a0e4a2860fd496ca66f6eff41dfd0232022-12-21T21:10:27ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802017-08-016810.1161/JAHA.117.006355Prognostic Value of the CHADS2 Score for Adverse Cardiovascular Events in Coronary Artery Disease Patients Without Atrial Fibrillation—A Multi‐Center Observational Cohort StudyNoriaki Tabata0Eiichiro Yamamoto1Seiji Hokimoto2Takayoshi Yamashita3Daisuke Sueta4Seiji Takashio5Yuichiro Arima6Yasuhiro Izumiya7Sunao Kojima8Koichi Kaikita9Kunihiko Matsui10Kazuteru Fujimoto11Kenji Sakamoto12Hideki Shimomura13Ryusuke Tsunoda14Toyoki Hirose15Natsuki Nakamura16Naritsugu Sakaino17Shinichi Nakamura18Nobuyasu Yamamoto19Toshiyuki Matsumura20Ichiro Kajiwara21Shunichi Koide22Tomohiro Sakamoto23Koichi Nakao24Shuichi Oshima25Kenichi Tsujita26Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanDepartment of Community Medicine, Kumamoto University Hospital, Kumamoto, JapanDivision of Cardiology, National Hospital Organization Kumamoto Medical Center, Kumamoto, JapanDivision of Cardiology, Kumamoto City Hospital, Kumamoto, JapanDivision of Cardiology, Fukuoka Tokushukai Hospital, Fukuoka, JapanDivision of Cardiology, Kumamoto Red Cross Hospital, Kumamoto, JapanDivision of Cardiology Minamata City Hospital and Medical Center, Minamata, JapanDivision of Cardiology, Shinbeppu Hospital, Beppu, JapanDivision of Cardiology, Amakusa Regional Medical Center, Amakusa, JapanDivision of Cardiology, Hitoyoshi General Hospital, Hitoyoshi, JapanMiyazaki Prefectural Nobeoka Hospital, Nobeoka, JapanDivision of Cardiology, Kumamoto Rosai Hospital, Yatsushiro, JapanDivision of Cardiology, Arao City Hospital, Arao, JapanDivision of Cardiology, Kumamoto General Hospital, Yatsushiro, JapanCardiovascular Center, Kumamoto Saiseikai Hospital, Kumamoto, JapanCardiovascular Center, Kumamoto Saiseikai Hospital, Kumamoto, JapanDivision of Cardiology, Kumamoto Central Hospital, Kumamoto, JapanDepartment of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, JapanBackgroundThe CHADS2 score has mainly been used to predict the likelihood of cerebrovascular accidents in patients with atrial fibrillation. However, increasing attention is being paid to this scoring system for risk stratification of patients with coronary artery disease. We investigated the value of the CHADS2 score in predicting cardiovascular/cerebrovascular events in coronary artery disease patients without atrial fibrillation. Methods and ResultsThis was a multicenter, observational cohort study. The subjects had been admitted to one of the participating institutions with coronary artery disease requiring percutaneous coronary intervention. We calculated the CHADS2 scores for 7082 patients (mean age, 69.7 years; males, 71.9%) without clinical evidence of atrial fibrillation. Subjects were subdivided into low‐ (0–1), intermediate‐ (2–3), and high‐score (4–6) groups and followed for 1 year. The end point was a composite of cardiovascular/cerebrovascular death, nonfatal myocardial infarction, and ischemic stroke at 1‐year follow‐up. Rates of triple‐vessel/left main trunk disease correlated positively with CHADS2 score categories. CHADS2 scores among single, double, and triple‐vessel/left main trunk groups were 2 (1–2), 2 (1–3), and 2 (2–3), respectively (P<0.001). A total of 194 patients (2.8%) had a cardiovascular/cerebrovascular event, and Kaplan–Meier analysis demonstrated a significantly higher probability of cardiovascular/cerebrovascular events in proportion to a higher CHADS2 score (log‐rank test, P<0.001). Multivariate Cox hazard analysis identified CHADS2 score (per 1 point) as an independent predictor of cardiovascular/cerebrovascular events (hazard ratio, 1.31; 95% CI, 1.17–1.47; P<0.001). ConclusionsThis large cohort study indicated that the CHADS2 score is useful for the prediction of cardiovascular/cerebrovascular events in coronary artery disease patients without atrial fibrillation.https://www.ahajournals.org/doi/10.1161/JAHA.117.006355cardiovascular disease risk factorscardiovascular eventscoronary artery diseaserisk stratification |
| spellingShingle | Noriaki Tabata Eiichiro Yamamoto Seiji Hokimoto Takayoshi Yamashita Daisuke Sueta Seiji Takashio Yuichiro Arima Yasuhiro Izumiya Sunao Kojima Koichi Kaikita Kunihiko Matsui Kazuteru Fujimoto Kenji Sakamoto Hideki Shimomura Ryusuke Tsunoda Toyoki Hirose Natsuki Nakamura Naritsugu Sakaino Shinichi Nakamura Nobuyasu Yamamoto Toshiyuki Matsumura Ichiro Kajiwara Shunichi Koide Tomohiro Sakamoto Koichi Nakao Shuichi Oshima Kenichi Tsujita Prognostic Value of the CHADS2 Score for Adverse Cardiovascular Events in Coronary Artery Disease Patients Without Atrial Fibrillation—A Multi‐Center Observational Cohort Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular disease risk factors cardiovascular events coronary artery disease risk stratification |
| title | Prognostic Value of the CHADS2 Score for Adverse Cardiovascular Events in Coronary Artery Disease Patients Without Atrial Fibrillation—A Multi‐Center Observational Cohort Study |
| title_full | Prognostic Value of the CHADS2 Score for Adverse Cardiovascular Events in Coronary Artery Disease Patients Without Atrial Fibrillation—A Multi‐Center Observational Cohort Study |
| title_fullStr | Prognostic Value of the CHADS2 Score for Adverse Cardiovascular Events in Coronary Artery Disease Patients Without Atrial Fibrillation—A Multi‐Center Observational Cohort Study |
| title_full_unstemmed | Prognostic Value of the CHADS2 Score for Adverse Cardiovascular Events in Coronary Artery Disease Patients Without Atrial Fibrillation—A Multi‐Center Observational Cohort Study |
| title_short | Prognostic Value of the CHADS2 Score for Adverse Cardiovascular Events in Coronary Artery Disease Patients Without Atrial Fibrillation—A Multi‐Center Observational Cohort Study |
| title_sort | prognostic value of the chads2 score for adverse cardiovascular events in coronary artery disease patients without atrial fibrillation a multi center observational cohort study |
| topic | cardiovascular disease risk factors cardiovascular events coronary artery disease risk stratification |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.117.006355 |
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