Synthesis and Modification of Hydroxyapatite Nanofiber for Poly(Lactic Acid) Composites with Enhanced Mechanical Strength and Bioactivity
To enhance the bioactivity of poly(lactic acid) (PLA), a potential bone repair material, without the lowering of mechanical strength, hydroxyapatite (HA) was introduced in the form of nanofibers as the filler for application in spinal implant materials. HA nanofibers (HANF) with aspect ratio as high...
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MDPI AG
2021-01-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/1/213 |
| _version_ | 1797411024241950720 |
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| author | Han-Seung Ko Sangwoon Lee Jae Young Jho |
| author_facet | Han-Seung Ko Sangwoon Lee Jae Young Jho |
| author_sort | Han-Seung Ko |
| collection | DOAJ |
| description | To enhance the bioactivity of poly(lactic acid) (PLA), a potential bone repair material, without the lowering of mechanical strength, hydroxyapatite (HA) was introduced in the form of nanofibers as the filler for application in spinal implant materials. HA nanofibers (HANF) with aspect ratio as high as ~100 were synthesized by controlling the starting pH of the reaction. While the tensile and flexural strength of PLA/HANF composites were enhanced compared with those of PLA resin, and were higher for the composites with HANF of higher aspect ratio. To further strengthen the composites, HANF was grafted with PLA chain to form HANF-g-PLA, which could improve the interface between the HANF and matrix PLA. PLA/HANF-g-PLA composites showed even higher tensile and flexural strength than PLA/HANF composites, apparently due to the better dispersion and interfacial adhesion. The composite containing 10 wt% HANF-g-PLA showed the flexural strength of 124 MPa, which was 25% higher than that of PLA resin. In the bioactivity test using a simulated body fluid solution, the rate and uniformity of the apatite growth were observed to be higher for the composites with HANF, and were even higher for those with HANF-g-PLA. This study suggested the possibility of using the PLA/HANF-g-PLA composite in the field of spinal implant materials. |
| first_indexed | 2024-03-09T04:39:00Z |
| format | Article |
| id | doaj.art-5a0e8c4bdf9c4abaa035ddb04d0c167b |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T04:39:00Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-5a0e8c4bdf9c4abaa035ddb04d0c167b2023-12-03T13:24:07ZengMDPI AGNanomaterials2079-49912021-01-0111121310.3390/nano11010213Synthesis and Modification of Hydroxyapatite Nanofiber for Poly(Lactic Acid) Composites with Enhanced Mechanical Strength and BioactivityHan-Seung Ko0Sangwoon Lee1Jae Young Jho2School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, KoreaSchool of Chemical and Biological Engineering, Seoul National University, Seoul 08826, KoreaSchool of Chemical and Biological Engineering, Seoul National University, Seoul 08826, KoreaTo enhance the bioactivity of poly(lactic acid) (PLA), a potential bone repair material, without the lowering of mechanical strength, hydroxyapatite (HA) was introduced in the form of nanofibers as the filler for application in spinal implant materials. HA nanofibers (HANF) with aspect ratio as high as ~100 were synthesized by controlling the starting pH of the reaction. While the tensile and flexural strength of PLA/HANF composites were enhanced compared with those of PLA resin, and were higher for the composites with HANF of higher aspect ratio. To further strengthen the composites, HANF was grafted with PLA chain to form HANF-g-PLA, which could improve the interface between the HANF and matrix PLA. PLA/HANF-g-PLA composites showed even higher tensile and flexural strength than PLA/HANF composites, apparently due to the better dispersion and interfacial adhesion. The composite containing 10 wt% HANF-g-PLA showed the flexural strength of 124 MPa, which was 25% higher than that of PLA resin. In the bioactivity test using a simulated body fluid solution, the rate and uniformity of the apatite growth were observed to be higher for the composites with HANF, and were even higher for those with HANF-g-PLA. This study suggested the possibility of using the PLA/HANF-g-PLA composite in the field of spinal implant materials.https://www.mdpi.com/2079-4991/11/1/213hydroxyapatite nanofiberpoly(lactic acid)polymer compositepolymer graftingmechanical properties |
| spellingShingle | Han-Seung Ko Sangwoon Lee Jae Young Jho Synthesis and Modification of Hydroxyapatite Nanofiber for Poly(Lactic Acid) Composites with Enhanced Mechanical Strength and Bioactivity Nanomaterials hydroxyapatite nanofiber poly(lactic acid) polymer composite polymer grafting mechanical properties |
| title | Synthesis and Modification of Hydroxyapatite Nanofiber for Poly(Lactic Acid) Composites with Enhanced Mechanical Strength and Bioactivity |
| title_full | Synthesis and Modification of Hydroxyapatite Nanofiber for Poly(Lactic Acid) Composites with Enhanced Mechanical Strength and Bioactivity |
| title_fullStr | Synthesis and Modification of Hydroxyapatite Nanofiber for Poly(Lactic Acid) Composites with Enhanced Mechanical Strength and Bioactivity |
| title_full_unstemmed | Synthesis and Modification of Hydroxyapatite Nanofiber for Poly(Lactic Acid) Composites with Enhanced Mechanical Strength and Bioactivity |
| title_short | Synthesis and Modification of Hydroxyapatite Nanofiber for Poly(Lactic Acid) Composites with Enhanced Mechanical Strength and Bioactivity |
| title_sort | synthesis and modification of hydroxyapatite nanofiber for poly lactic acid composites with enhanced mechanical strength and bioactivity |
| topic | hydroxyapatite nanofiber poly(lactic acid) polymer composite polymer grafting mechanical properties |
| url | https://www.mdpi.com/2079-4991/11/1/213 |
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