Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases
The prevalence of type 2 diabetes is increasing world-wide. Thus, it is necessary to better understand its pathogenesis, the risk of diabetes-associated complications and effective treatment strategies. Because type 2 diabetes is a very heterogenous disease, both, related to its pathogenesis and ris...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2019-12-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/10376 |
| _version_ | 1797255141564350464 |
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| author | Norbert Stefan |
| author_facet | Norbert Stefan |
| author_sort | Norbert Stefan |
| collection | DOAJ |
| description | The prevalence of type 2 diabetes is increasing world-wide. Thus, it is necessary to better understand its pathogenesis, the risk of diabetes-associated complications and effective treatment strategies. Because type 2 diabetes is a very heterogenous disease, both, related to its pathogenesis and risk of complications, phenotyping strategies in diabetes may help to tailor the preventive strategies based on the individual’s risk. As the the hyperglycemic state of prediabetes is already associated with an increased risk of cardiometabolic diseases it is necessary to investigate the impact of phenotypes for predictive and preventive outcomes already in this early state of hyperglycemia. In this review artice I discuss how important phenotypes of prediabetes, such as nonalcoholic fatty liver disease, visceral obesity, insulin secretion defect and insulin resistance can be used to improve the prediction and prevention of type 2 diabetes and cardiovascular disease. |
| first_indexed | 2024-03-08T15:20:08Z |
| format | Article |
| id | doaj.art-5a10ac3c042c43b2ac4c81f889878add |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:01:08Z |
| publishDate | 2019-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-5a10ac3c042c43b2ac4c81f889878add2024-03-20T11:48:02ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782019-12-0122657758110.14341/DM1037610485Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseasesNorbert Stefan0University Hospital Tübingen; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich at the University of Tübingen; German Center for Diabetes Research (DZD)The prevalence of type 2 diabetes is increasing world-wide. Thus, it is necessary to better understand its pathogenesis, the risk of diabetes-associated complications and effective treatment strategies. Because type 2 diabetes is a very heterogenous disease, both, related to its pathogenesis and risk of complications, phenotyping strategies in diabetes may help to tailor the preventive strategies based on the individual’s risk. As the the hyperglycemic state of prediabetes is already associated with an increased risk of cardiometabolic diseases it is necessary to investigate the impact of phenotypes for predictive and preventive outcomes already in this early state of hyperglycemia. In this review artice I discuss how important phenotypes of prediabetes, such as nonalcoholic fatty liver disease, visceral obesity, insulin secretion defect and insulin resistance can be used to improve the prediction and prevention of type 2 diabetes and cardiovascular disease.https://www.dia-endojournals.ru/jour/article/view/10376prediabetes, diabetes mellitus type 2profilacticcardiovascular diseases |
| spellingShingle | Norbert Stefan Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases Сахарный диабет prediabetes, diabetes mellitus type 2 profilactic cardiovascular diseases |
| title | Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases |
| title_full | Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases |
| title_fullStr | Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases |
| title_full_unstemmed | Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases |
| title_short | Phenotypes of prediabetes: pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases |
| title_sort | phenotypes of prediabetes pathogenesis and consequences for prediction and prevention of type 2 diabetes and cardiovascular diseases |
| topic | prediabetes, diabetes mellitus type 2 profilactic cardiovascular diseases |
| url | https://www.dia-endojournals.ru/jour/article/view/10376 |
| work_keys_str_mv | AT norbertstefan phenotypesofprediabetespathogenesisandconsequencesforpredictionandpreventionoftype2diabetesandcardiovasculardiseases |