The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes
Background Clonal hematopoiesis of indeterminate potential (CHIP) has been reported to be associated with increased cardiovascular disease, aging and insulin resistance. Despite the debate of causal contribution of CHIP on metabolic diseases, we want to explore whether CHIP is related to diabetic pe...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2022-04-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2021-1337.pdf |
| _version_ | 1811302857741172736 |
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| author | Tae Jung Oh Han Song Youngil Koh Sung Hee Choi |
| author_facet | Tae Jung Oh Han Song Youngil Koh Sung Hee Choi |
| author_sort | Tae Jung Oh |
| collection | DOAJ |
| description | Background Clonal hematopoiesis of indeterminate potential (CHIP) has been reported to be associated with increased cardiovascular disease, aging and insulin resistance. Despite the debate of causal contribution of CHIP on metabolic diseases, we want to explore whether CHIP is related to diabetic peripheral neuropathy (DPN). Methods This study analyzed the prevalence of CHIP in patients with type 2 diabetes classified according to DPN status. Logistic regression analysis was used to evaluate the association between CHIP and DPN. Results CHIP was more prevalent in subjects without DPN than those with DPN (19.9% vs. 8.8%, respectively; P=0.013). Individuals having any CHIP, or DNA methyltransferase 3A (DNMT3A) CHIP were less likely to have any abnormality shown in DPN test; the adjusted odds ratio were 0.85 (95% confidence interval [CI], 0.73 to 1.00) and 0.70 (95% CI, 0.56 to 0.89), respectively. Interestingly, DNMT3A CHIP showed the negative association, but Tet methylcytosine dioxygenase 2 (TET2) CHIP showed the positive association with abnormal feet electrochemical skin conductance level. Conclusion On the contrary to expectations, CHIP was negatively associated with DPN. Functional linking between the mutation in hematopoietic cells and DPN, and the opposite role of DNMT3A and TET2 should be investigated. |
| first_indexed | 2024-04-13T07:36:52Z |
| format | Article |
| id | doaj.art-5a1125ad88f24276995bb94c5a6b2973 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-04-13T07:36:52Z |
| publishDate | 2022-04-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-5a1125ad88f24276995bb94c5a6b29732022-12-22T02:56:07ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782022-04-0137224324810.3803/EnM.2021.13372291The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 DiabetesTae Jung Oh0Han Song1Youngil Koh2Sung Hee Choi3 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Genome Opinion Incorporation, Seoul, Korea Genome Opinion Incorporation, Seoul, Korea Department of Internal Medicine, Seoul National University College of Medicine, Seoul, KoreaBackground Clonal hematopoiesis of indeterminate potential (CHIP) has been reported to be associated with increased cardiovascular disease, aging and insulin resistance. Despite the debate of causal contribution of CHIP on metabolic diseases, we want to explore whether CHIP is related to diabetic peripheral neuropathy (DPN). Methods This study analyzed the prevalence of CHIP in patients with type 2 diabetes classified according to DPN status. Logistic regression analysis was used to evaluate the association between CHIP and DPN. Results CHIP was more prevalent in subjects without DPN than those with DPN (19.9% vs. 8.8%, respectively; P=0.013). Individuals having any CHIP, or DNA methyltransferase 3A (DNMT3A) CHIP were less likely to have any abnormality shown in DPN test; the adjusted odds ratio were 0.85 (95% confidence interval [CI], 0.73 to 1.00) and 0.70 (95% CI, 0.56 to 0.89), respectively. Interestingly, DNMT3A CHIP showed the negative association, but Tet methylcytosine dioxygenase 2 (TET2) CHIP showed the positive association with abnormal feet electrochemical skin conductance level. Conclusion On the contrary to expectations, CHIP was negatively associated with DPN. Functional linking between the mutation in hematopoietic cells and DPN, and the opposite role of DNMT3A and TET2 should be investigated.http://www.e-enm.org/upload/pdf/enm-2021-1337.pdfdiabetic neuropathiesclonal hematopoiesisrisk factors |
| spellingShingle | Tae Jung Oh Han Song Youngil Koh Sung Hee Choi The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes Endocrinology and Metabolism diabetic neuropathies clonal hematopoiesis risk factors |
| title | The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes |
| title_full | The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes |
| title_fullStr | The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes |
| title_full_unstemmed | The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes |
| title_short | The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes |
| title_sort | presence of clonal hematopoiesis is negatively associated with diabetic peripheral neuropathy in type 2 diabetes |
| topic | diabetic neuropathies clonal hematopoiesis risk factors |
| url | http://www.e-enm.org/upload/pdf/enm-2021-1337.pdf |
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