The Enhanced Activity of a Plant Mixture from the Brazilian Caatinga Biome against Venereal Trichomonads Confirms the Traditional Use
Women living in the semi-arid region of Caatinga in the northeast of Brazil report the use of plant mixtures to treat diseases in the genitourinary tract. Plant extracts were obtained from barks to simulate traditional use. The anti-trichomonads activity as well as the cytotoxic effect of plant extr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Venereology |
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| Online Access: | https://www.mdpi.com/2674-0710/3/1/2 |
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| author | Nícolas Luiz Feijó Silva Patrícia de Brum Vieira Márcia Vanusa da Silva Alexandre José Macedo Tiana Tasca |
| author_facet | Nícolas Luiz Feijó Silva Patrícia de Brum Vieira Márcia Vanusa da Silva Alexandre José Macedo Tiana Tasca |
| author_sort | Nícolas Luiz Feijó Silva |
| collection | DOAJ |
| description | Women living in the semi-arid region of Caatinga in the northeast of Brazil report the use of plant mixtures to treat diseases in the genitourinary tract. Plant extracts were obtained from barks to simulate traditional use. The anti-trichomonads activity as well as the cytotoxic effect of plant extracts were tested. Herein, we confirmed this traditional knowledge by testing plants aqueous extracts against <i>Trichomonas vaginalis</i> and <i>Tritrichomonas foetus</i>, the etiologic agents of human and bovine trichomoniasis. All plant extracts were active individually against at least one trichomonads species except for <i>Prosopis juliflora</i> and <i>Amburana cearensis</i>. <i>Cedrela</i> sp. was the most active against both trichomonads species. Finally, a mixture of plants used in traditional medicine was evaluated for activity. A mixture containing extracts of the plants <i>Ximenia americana</i>, <i>Anadenanthera colubrina</i> var. <i>cebil</i>, <i>Myracrodruon urundeuva</i>, <i>Sideroxylon obtusifolium</i>, and <i>Amburana cearensis</i> was active against the two trichomonads. This finding confirms the traditional practice by women living in the Caatinga region of using a mixture of plants during sitz baths to treat vaginal infections. Altogether, these results highlight the ethnopharmacological use of <i>Cedrela</i> sp. and of the plant mixture for the treatment of venereal diseases by Caatinga residents. |
| first_indexed | 2024-04-24T17:46:02Z |
| format | Article |
| id | doaj.art-5a131a0876984e3297a52ae91a7b0527 |
| institution | Directory Open Access Journal |
| issn | 2674-0710 |
| language | English |
| last_indexed | 2024-04-24T17:46:02Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Venereology |
| spelling | doaj.art-5a131a0876984e3297a52ae91a7b05272024-03-27T14:07:18ZengMDPI AGVenereology2674-07102024-01-0131152510.3390/venereology3010002The Enhanced Activity of a Plant Mixture from the Brazilian Caatinga Biome against Venereal Trichomonads Confirms the Traditional UseNícolas Luiz Feijó Silva0Patrícia de Brum Vieira1Márcia Vanusa da Silva2Alexandre José Macedo3Tiana Tasca4Faculdade de Farmácia e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, BrazilGrupo de Pesquisa Estresse Oxidativo e Sinalização Celular, Centro Interdisciplinar de Pesquisa em Biotecnologia—CIPBIOTEC, Universidade Federal do Pampa, São Gabriel 97300-000, RS, BrazilCentro de Ciências Biológicas e Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife 50670-901, PE, BrazilFaculdade de Farmácia e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, BrazilFaculdade de Farmácia e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, BrazilWomen living in the semi-arid region of Caatinga in the northeast of Brazil report the use of plant mixtures to treat diseases in the genitourinary tract. Plant extracts were obtained from barks to simulate traditional use. The anti-trichomonads activity as well as the cytotoxic effect of plant extracts were tested. Herein, we confirmed this traditional knowledge by testing plants aqueous extracts against <i>Trichomonas vaginalis</i> and <i>Tritrichomonas foetus</i>, the etiologic agents of human and bovine trichomoniasis. All plant extracts were active individually against at least one trichomonads species except for <i>Prosopis juliflora</i> and <i>Amburana cearensis</i>. <i>Cedrela</i> sp. was the most active against both trichomonads species. Finally, a mixture of plants used in traditional medicine was evaluated for activity. A mixture containing extracts of the plants <i>Ximenia americana</i>, <i>Anadenanthera colubrina</i> var. <i>cebil</i>, <i>Myracrodruon urundeuva</i>, <i>Sideroxylon obtusifolium</i>, and <i>Amburana cearensis</i> was active against the two trichomonads. This finding confirms the traditional practice by women living in the Caatinga region of using a mixture of plants during sitz baths to treat vaginal infections. Altogether, these results highlight the ethnopharmacological use of <i>Cedrela</i> sp. and of the plant mixture for the treatment of venereal diseases by Caatinga residents.https://www.mdpi.com/2674-0710/3/1/2anti-<i>Tritrichomonas foetus</i>anti-<i>Trichomonas vaginalis</i>bovine trichomoniasisCaatinga biomehuman trichomoniasisplant extracts |
| spellingShingle | Nícolas Luiz Feijó Silva Patrícia de Brum Vieira Márcia Vanusa da Silva Alexandre José Macedo Tiana Tasca The Enhanced Activity of a Plant Mixture from the Brazilian Caatinga Biome against Venereal Trichomonads Confirms the Traditional Use Venereology anti-<i>Tritrichomonas foetus</i> anti-<i>Trichomonas vaginalis</i> bovine trichomoniasis Caatinga biome human trichomoniasis plant extracts |
| title | The Enhanced Activity of a Plant Mixture from the Brazilian Caatinga Biome against Venereal Trichomonads Confirms the Traditional Use |
| title_full | The Enhanced Activity of a Plant Mixture from the Brazilian Caatinga Biome against Venereal Trichomonads Confirms the Traditional Use |
| title_fullStr | The Enhanced Activity of a Plant Mixture from the Brazilian Caatinga Biome against Venereal Trichomonads Confirms the Traditional Use |
| title_full_unstemmed | The Enhanced Activity of a Plant Mixture from the Brazilian Caatinga Biome against Venereal Trichomonads Confirms the Traditional Use |
| title_short | The Enhanced Activity of a Plant Mixture from the Brazilian Caatinga Biome against Venereal Trichomonads Confirms the Traditional Use |
| title_sort | enhanced activity of a plant mixture from the brazilian caatinga biome against venereal trichomonads confirms the traditional use |
| topic | anti-<i>Tritrichomonas foetus</i> anti-<i>Trichomonas vaginalis</i> bovine trichomoniasis Caatinga biome human trichomoniasis plant extracts |
| url | https://www.mdpi.com/2674-0710/3/1/2 |
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