Molecular sex differences in human serum.
Sex is an important factor in the prevalence, incidence, progression, and response to treatment of many medical conditions, including autoimmune and cardiovascular diseases and psychiatric conditions. Identification of molecular differences between typical males and females can provide a valuable ba...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3520798?pdf=render |
| _version_ | 1818572744693907456 |
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| author | Jordan M Ramsey Emanuel Schwarz Paul C Guest Nico J M van Beveren F Markus Leweke Matthias Rothermundt Bernhard Bogerts Johann Steiner Liliana Ruta Simon Baron-Cohen Sabine Bahn |
| author_facet | Jordan M Ramsey Emanuel Schwarz Paul C Guest Nico J M van Beveren F Markus Leweke Matthias Rothermundt Bernhard Bogerts Johann Steiner Liliana Ruta Simon Baron-Cohen Sabine Bahn |
| author_sort | Jordan M Ramsey |
| collection | DOAJ |
| description | Sex is an important factor in the prevalence, incidence, progression, and response to treatment of many medical conditions, including autoimmune and cardiovascular diseases and psychiatric conditions. Identification of molecular differences between typical males and females can provide a valuable basis for exploring conditions differentially affected by sex.Using multiplexed immunoassays, we analyzed 174 serum molecules in 9 independent cohorts of typical individuals, comprising 196 males and 196 females. Sex differences in analyte levels were quantified using a meta-analysis approach and put into biological context using k-means to generate clusters of analytes with distinct biological functions. Natural sex differences were established in these analyte groups and these were applied to illustrate sexually dimorphic analyte expression in a cohort of 22 males and 22 females with Asperger syndrome. Reproducible sex differences were found in the levels of 77 analytes in serum of typical controls, and these comprised clusters of molecules enriched with distinct biological functions. Analytes involved in fatty acid oxidation/hormone regulation, immune cell growth and activation, and cell death were found at higher levels in females, and analytes involved in immune cell chemotaxis and other indistinct functions were higher in males. Comparison of these naturally occurring sex differences against a cohort of people with Asperger syndrome indicated that a cluster of analytes that had functions related to fatty acid oxidation/hormone regulation was associated with sex and the occurrence of this condition.Sex-specific molecular differences were detected in serum of typical controls and these were reproducible across independent cohorts. This study extends current knowledge of sex differences in biological functions involved in metabolism and immune function. Deviations from typical sex differences were found in a cluster of molecules in Asperger syndrome. These findings illustrate the importance of investigating the influence of sex on medical conditions. |
| first_indexed | 2024-12-15T00:01:45Z |
| format | Article |
| id | doaj.art-5a148c9f0e184827a33de7b4847ab2b1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-15T00:01:45Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5a148c9f0e184827a33de7b4847ab2b12022-12-21T22:42:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5150410.1371/journal.pone.0051504Molecular sex differences in human serum.Jordan M RamseyEmanuel SchwarzPaul C GuestNico J M van BeverenF Markus LewekeMatthias RothermundtBernhard BogertsJohann SteinerLiliana RutaSimon Baron-CohenSabine BahnSex is an important factor in the prevalence, incidence, progression, and response to treatment of many medical conditions, including autoimmune and cardiovascular diseases and psychiatric conditions. Identification of molecular differences between typical males and females can provide a valuable basis for exploring conditions differentially affected by sex.Using multiplexed immunoassays, we analyzed 174 serum molecules in 9 independent cohorts of typical individuals, comprising 196 males and 196 females. Sex differences in analyte levels were quantified using a meta-analysis approach and put into biological context using k-means to generate clusters of analytes with distinct biological functions. Natural sex differences were established in these analyte groups and these were applied to illustrate sexually dimorphic analyte expression in a cohort of 22 males and 22 females with Asperger syndrome. Reproducible sex differences were found in the levels of 77 analytes in serum of typical controls, and these comprised clusters of molecules enriched with distinct biological functions. Analytes involved in fatty acid oxidation/hormone regulation, immune cell growth and activation, and cell death were found at higher levels in females, and analytes involved in immune cell chemotaxis and other indistinct functions were higher in males. Comparison of these naturally occurring sex differences against a cohort of people with Asperger syndrome indicated that a cluster of analytes that had functions related to fatty acid oxidation/hormone regulation was associated with sex and the occurrence of this condition.Sex-specific molecular differences were detected in serum of typical controls and these were reproducible across independent cohorts. This study extends current knowledge of sex differences in biological functions involved in metabolism and immune function. Deviations from typical sex differences were found in a cluster of molecules in Asperger syndrome. These findings illustrate the importance of investigating the influence of sex on medical conditions.http://europepmc.org/articles/PMC3520798?pdf=render |
| spellingShingle | Jordan M Ramsey Emanuel Schwarz Paul C Guest Nico J M van Beveren F Markus Leweke Matthias Rothermundt Bernhard Bogerts Johann Steiner Liliana Ruta Simon Baron-Cohen Sabine Bahn Molecular sex differences in human serum. PLoS ONE |
| title | Molecular sex differences in human serum. |
| title_full | Molecular sex differences in human serum. |
| title_fullStr | Molecular sex differences in human serum. |
| title_full_unstemmed | Molecular sex differences in human serum. |
| title_short | Molecular sex differences in human serum. |
| title_sort | molecular sex differences in human serum |
| url | http://europepmc.org/articles/PMC3520798?pdf=render |
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