NcRNA-regulated CAPZA1 associated with prognostic and immunological effects across lung adenocarcinoma
Recent discoveries have suggested that the F-actin capping protein α1 subunit (CAPZA1) in various human tumors could play a significantly important role in regulating cell proliferation, metastasis, and epithelial–mesenchymal transition. However, the immune-regulating role of CAPZA1 in the initiatio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1025192/full |
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| author | Tingting Qin Wanping Xiang Wanping Xiang Yiming Mao Hongyan Zhai Zhihao Yang Zhihao Yang Hongpan Zhang Hongpan Zhang |
| author_facet | Tingting Qin Wanping Xiang Wanping Xiang Yiming Mao Hongyan Zhai Zhihao Yang Zhihao Yang Hongpan Zhang Hongpan Zhang |
| author_sort | Tingting Qin |
| collection | DOAJ |
| description | Recent discoveries have suggested that the F-actin capping protein α1 subunit (CAPZA1) in various human tumors could play a significantly important role in regulating cell proliferation, metastasis, and epithelial–mesenchymal transition. However, the immune-regulating role of CAPZA1 in the initiation and development of lung adenocarcinoma (LUAD) remains unclear. In our research, we first found that CAPZA1 serves as an oncogene in pan-cancers from the TCGA data and higher CAPZA1 expression process unfavorably prognostic value in LUAD based on starBase database, PrognoScan, and LOGpc database. Then, in our analyses, lncRNAs AC026356.1 in LUAD acted as a competitive endogenous RNA (ceRNA) of miR-30d-5p, which might be the possible regulatory miRNA of CAPZA1 based on the starBase database. Finally, we confirmed that CAPZA1 expression had a tightly positive correlation with immune infiltration cells, immune infiltration markers, TMB, MSI, immune score, stromal score, and immune checkpoints, indicating that CAPZA1 was a markedly reliable therapeutic target for immunological antitumor strategies. In conclusion, our investigations revealed that CAPZA1 might function as an immune-associated biomarker in the development and treatment of LUAD, thereby acting as a promising prognostic and therapeutic target against LUAD. |
| first_indexed | 2024-04-11T01:03:02Z |
| format | Article |
| id | doaj.art-5a174afeb3004328b86801ad77b69118 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T01:03:02Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5a174afeb3004328b86801ad77b691182023-01-04T14:57:59ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.10251921025192NcRNA-regulated CAPZA1 associated with prognostic and immunological effects across lung adenocarcinomaTingting Qin0Wanping Xiang1Wanping Xiang2Yiming Mao3Hongyan Zhai4Zhihao Yang5Zhihao Yang6Hongpan Zhang7Hongpan Zhang8Department of Oncology, Wuhan Third Hospital, Wuhan, Hubei, ChinaNorth Sichuan Medical College, Nanchong, Sichuan, ChinaDepartment of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaSuzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, Jiangsu, ChinaDepartment of Oncology, Linfen People’s Hospital, Linfen, Shanxi, ChinaNorth Sichuan Medical College, Nanchong, Sichuan, ChinaTianjin Key Laboratory of Medical Epigenetics, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, ChinaNorth Sichuan Medical College, Nanchong, Sichuan, ChinaDepartment of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, ChinaRecent discoveries have suggested that the F-actin capping protein α1 subunit (CAPZA1) in various human tumors could play a significantly important role in regulating cell proliferation, metastasis, and epithelial–mesenchymal transition. However, the immune-regulating role of CAPZA1 in the initiation and development of lung adenocarcinoma (LUAD) remains unclear. In our research, we first found that CAPZA1 serves as an oncogene in pan-cancers from the TCGA data and higher CAPZA1 expression process unfavorably prognostic value in LUAD based on starBase database, PrognoScan, and LOGpc database. Then, in our analyses, lncRNAs AC026356.1 in LUAD acted as a competitive endogenous RNA (ceRNA) of miR-30d-5p, which might be the possible regulatory miRNA of CAPZA1 based on the starBase database. Finally, we confirmed that CAPZA1 expression had a tightly positive correlation with immune infiltration cells, immune infiltration markers, TMB, MSI, immune score, stromal score, and immune checkpoints, indicating that CAPZA1 was a markedly reliable therapeutic target for immunological antitumor strategies. In conclusion, our investigations revealed that CAPZA1 might function as an immune-associated biomarker in the development and treatment of LUAD, thereby acting as a promising prognostic and therapeutic target against LUAD.https://www.frontiersin.org/articles/10.3389/fonc.2022.1025192/fullLUADCAPZA1ceRNAprognosisimmunotherapy |
| spellingShingle | Tingting Qin Wanping Xiang Wanping Xiang Yiming Mao Hongyan Zhai Zhihao Yang Zhihao Yang Hongpan Zhang Hongpan Zhang NcRNA-regulated CAPZA1 associated with prognostic and immunological effects across lung adenocarcinoma Frontiers in Oncology LUAD CAPZA1 ceRNA prognosis immunotherapy |
| title | NcRNA-regulated CAPZA1 associated with prognostic and immunological effects across lung adenocarcinoma |
| title_full | NcRNA-regulated CAPZA1 associated with prognostic and immunological effects across lung adenocarcinoma |
| title_fullStr | NcRNA-regulated CAPZA1 associated with prognostic and immunological effects across lung adenocarcinoma |
| title_full_unstemmed | NcRNA-regulated CAPZA1 associated with prognostic and immunological effects across lung adenocarcinoma |
| title_short | NcRNA-regulated CAPZA1 associated with prognostic and immunological effects across lung adenocarcinoma |
| title_sort | ncrna regulated capza1 associated with prognostic and immunological effects across lung adenocarcinoma |
| topic | LUAD CAPZA1 ceRNA prognosis immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1025192/full |
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