Tumor-Induced Osteomalacia: A Case Report of Rare Disease and Literature review
Abstract Shivam Bansal Mohit Dhingra Background Oncogenic osteomalacia term used for tumor-induced osteomalacia (TIO) is a...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2023-06-01
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| Series: | South Asian Journal of Cancer |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1768681 |
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| author | Shivam Bansal Vikas Maheshwari Bishwa Bandhu Niraula Anil Regmi Kalyani Sridharan Mohit Dhingra |
| author_facet | Shivam Bansal Vikas Maheshwari Bishwa Bandhu Niraula Anil Regmi Kalyani Sridharan Mohit Dhingra |
| author_sort | Shivam Bansal |
| collection | DOAJ |
| description | Abstract
Shivam Bansal
Mohit Dhingra
Background Oncogenic osteomalacia term used for tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome of abnormal phosphate metabolism secondary to ectopic endocrine tumors. The diagnosis often becomes difficult due to rarity of occurrence and deficient literature. The reconstruction following resection has its own technical difficulties, which are addressed in this article.
Presentation of Case A 39-year-old female presented with pain in bilateral lower limbs and difficulty in mobilizing. The patient had unexplained hypophosphatemia which was diagnosed due to tumor (arising ectopically in greater trochanter), inducing osteomalacia. She was managed successfully with excision of tumor and reconstruction. The biochemical parameters improved drastically within 5 days and fracture healed in 6 weeks' time.
Conclusion TIO is a debilitating disease with significant morbidity due to prolonged onset to diagnosis interval and difficulty in localizing the causative tumor. So thorough clinico-radiological and laboratory parameter correlation is a necessity. A rapid diagnosis followed by complete surgical excision, which remains the gold standard treatment modality that confers favorable prognosis in most patients, with strict vigilance for recurrence is required. |
| first_indexed | 2024-03-13T06:19:37Z |
| format | Article |
| id | doaj.art-5a1905ed299845eabb24a14ea570a62b |
| institution | Directory Open Access Journal |
| issn | 2278-330X 2278-4306 |
| language | English |
| last_indexed | 2024-03-13T06:19:37Z |
| publishDate | 2023-06-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | South Asian Journal of Cancer |
| spelling | doaj.art-5a1905ed299845eabb24a14ea570a62b2023-06-09T23:00:46ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2278-43062023-06-0110.1055/s-0043-1768681Tumor-Induced Osteomalacia: A Case Report of Rare Disease and Literature reviewShivam Bansal0Vikas Maheshwari1Bishwa Bandhu Niraula2Anil Regmi3Kalyani Sridharan4Mohit Dhingra5Department of Orthopedics, All India Institute of Medical Science (AIIMS) Rishikesh, Rishikesh, Uttarakhand, IndiaDepartment of Orthopedics, All India Institute of Medical Science (AIIMS) Rishikesh, Rishikesh, Uttarakhand, IndiaDepartment of Orthopedics, All India Institute of Medical Science (AIIMS) Rishikesh, Rishikesh, Uttarakhand, IndiaDepartment of Orthopedics, All India Institute of Medical Science (AIIMS) Rishikesh, Rishikesh, Uttarakhand, IndiaDepartment of Endocrinology, All India Institute of Medical Science (AIIMS) Rishikesh, Rishikesh, Uttarakhand, IndiaDepartment of Orthopedics, All India Institute of Medical Science (AIIMS) Rishikesh, Rishikesh, Uttarakhand, IndiaAbstract Shivam Bansal Mohit Dhingra Background Oncogenic osteomalacia term used for tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome of abnormal phosphate metabolism secondary to ectopic endocrine tumors. The diagnosis often becomes difficult due to rarity of occurrence and deficient literature. The reconstruction following resection has its own technical difficulties, which are addressed in this article. Presentation of Case A 39-year-old female presented with pain in bilateral lower limbs and difficulty in mobilizing. The patient had unexplained hypophosphatemia which was diagnosed due to tumor (arising ectopically in greater trochanter), inducing osteomalacia. She was managed successfully with excision of tumor and reconstruction. The biochemical parameters improved drastically within 5 days and fracture healed in 6 weeks' time. Conclusion TIO is a debilitating disease with significant morbidity due to prolonged onset to diagnosis interval and difficulty in localizing the causative tumor. So thorough clinico-radiological and laboratory parameter correlation is a necessity. A rapid diagnosis followed by complete surgical excision, which remains the gold standard treatment modality that confers favorable prognosis in most patients, with strict vigilance for recurrence is required.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1768681tumor-induced osteomalaciagreater trochanter reconstructionphosphaturic mesenchymal tumorfragility fracturesurgical technique |
| spellingShingle | Shivam Bansal Vikas Maheshwari Bishwa Bandhu Niraula Anil Regmi Kalyani Sridharan Mohit Dhingra Tumor-Induced Osteomalacia: A Case Report of Rare Disease and Literature review South Asian Journal of Cancer tumor-induced osteomalacia greater trochanter reconstruction phosphaturic mesenchymal tumor fragility fracture surgical technique |
| title | Tumor-Induced Osteomalacia: A Case Report of Rare Disease and Literature review |
| title_full | Tumor-Induced Osteomalacia: A Case Report of Rare Disease and Literature review |
| title_fullStr | Tumor-Induced Osteomalacia: A Case Report of Rare Disease and Literature review |
| title_full_unstemmed | Tumor-Induced Osteomalacia: A Case Report of Rare Disease and Literature review |
| title_short | Tumor-Induced Osteomalacia: A Case Report of Rare Disease and Literature review |
| title_sort | tumor induced osteomalacia a case report of rare disease and literature review |
| topic | tumor-induced osteomalacia greater trochanter reconstruction phosphaturic mesenchymal tumor fragility fracture surgical technique |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1768681 |
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