Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis
IntroductionAlopecia areata (AA) is a non-scarring hair loss condition, subclassified into AA, alopecia universalis, and alopecia totalis. There are indications that people with AA experience adverse psychosocial outcomes, but previous studies have not included a thorough meta-analysis and did not c...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1054898/full |
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| author | Marije van Dalen Marije van Dalen Kirsten S. Muller Johanna M. Kasperkovitz-Oosterloo Johanna M. Kasperkovitz-Oosterloo Jolanda M. E. Okkerse Suzanne G. M. A. Pasmans |
| author_facet | Marije van Dalen Marije van Dalen Kirsten S. Muller Johanna M. Kasperkovitz-Oosterloo Johanna M. Kasperkovitz-Oosterloo Jolanda M. E. Okkerse Suzanne G. M. A. Pasmans |
| author_sort | Marije van Dalen |
| collection | DOAJ |
| description | IntroductionAlopecia areata (AA) is a non-scarring hair loss condition, subclassified into AA, alopecia universalis, and alopecia totalis. There are indications that people with AA experience adverse psychosocial outcomes, but previous studies have not included a thorough meta-analysis and did not compare people with AA to people with other dermatological diagnoses. Therefore, the aim of this systematic review and meta-analysis was to update and expand previous systematic reviews, as well as describing and quantifying levels of anxiety, depression, and quality of life (QoL) in children and adults with AA.MethodsA search was conducted, yielding 1,249 unique records of which 93 were included.ResultsReview results showed that people with AA have higher chances of being diagnosed with anxiety and/or depression and experience impaired QoL. Their psychosocial outcomes are often similar to other people with a dermatological condition. Meta-analytic results showed significantly more symptoms of anxiety and depression in adults with AA compared to healthy controls. Results also showed a moderate impact on QoL. These results further highlight that AA, despite causing little physical impairments, can have a significant amount on patients’ well-being.DiscussionFuture studies should examine the influence of disease severity, disease duration, remission and relapse, and medication use to shed light on at-risk groups in need of referral to psychological care.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42022323174]. |
| first_indexed | 2024-04-11T07:41:40Z |
| format | Article |
| id | doaj.art-5a19b2555cd744999abc6c9bf2fd7c43 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T07:41:40Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-5a19b2555cd744999abc6c9bf2fd7c432022-12-22T04:36:29ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-11-01910.3389/fmed.2022.10548981054898Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysisMarije van Dalen0Marije van Dalen1Kirsten S. Muller2Johanna M. Kasperkovitz-Oosterloo3Johanna M. Kasperkovitz-Oosterloo4Jolanda M. E. Okkerse5Suzanne G. M. A. Pasmans6Department of Pediatric Gastroenterology, Erasmus MC Sophia Children’s Hospital, Rotterdam, NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC Sophia Children’s Hospital, Rotterdam, NetherlandsDepartment of Pediatric Gastroenterology, Erasmus MC Sophia Children’s Hospital, Rotterdam, NetherlandsDutch Alopecia Association, ’s-Hertogenbosch, NetherlandsIPSO Institutes for Psychosocial Oncology, Almere, NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC Sophia Children’s Hospital, Rotterdam, NetherlandsDepartment of Dermatology, Center of Pediatric Dermatology, Erasmus MC Sophia Children’s Hospital, Rotterdam, NetherlandsIntroductionAlopecia areata (AA) is a non-scarring hair loss condition, subclassified into AA, alopecia universalis, and alopecia totalis. There are indications that people with AA experience adverse psychosocial outcomes, but previous studies have not included a thorough meta-analysis and did not compare people with AA to people with other dermatological diagnoses. Therefore, the aim of this systematic review and meta-analysis was to update and expand previous systematic reviews, as well as describing and quantifying levels of anxiety, depression, and quality of life (QoL) in children and adults with AA.MethodsA search was conducted, yielding 1,249 unique records of which 93 were included.ResultsReview results showed that people with AA have higher chances of being diagnosed with anxiety and/or depression and experience impaired QoL. Their psychosocial outcomes are often similar to other people with a dermatological condition. Meta-analytic results showed significantly more symptoms of anxiety and depression in adults with AA compared to healthy controls. Results also showed a moderate impact on QoL. These results further highlight that AA, despite causing little physical impairments, can have a significant amount on patients’ well-being.DiscussionFuture studies should examine the influence of disease severity, disease duration, remission and relapse, and medication use to shed light on at-risk groups in need of referral to psychological care.Systematic review registration[https://www.crd.york.ac.uk/prospero/], identifier [CRD42022323174].https://www.frontiersin.org/articles/10.3389/fmed.2022.1054898/fullalopeciaalopecia areatapsychosocial functioninganxietydepressionquality of life |
| spellingShingle | Marije van Dalen Marije van Dalen Kirsten S. Muller Johanna M. Kasperkovitz-Oosterloo Johanna M. Kasperkovitz-Oosterloo Jolanda M. E. Okkerse Suzanne G. M. A. Pasmans Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis Frontiers in Medicine alopecia alopecia areata psychosocial functioning anxiety depression quality of life |
| title | Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis |
| title_full | Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis |
| title_fullStr | Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis |
| title_full_unstemmed | Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis |
| title_short | Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis |
| title_sort | anxiety depression and quality of life in children and adults with alopecia areata a systematic review and meta analysis |
| topic | alopecia alopecia areata psychosocial functioning anxiety depression quality of life |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1054898/full |
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