Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARα and PPARγ

Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARα and PPARγ

UDP-glucuronosyltransferase 1A1 (UGT1A1) is an essential enzyme in mammals that is responsible for detoxification and metabolic clearance of the endogenous toxin bilirubin and a variety of xenobiotics, including some crucial therapeutic drugs. Discovery of potent and safe UGT1A1 inducers will provid...

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Bibliographic Details
Main Authors:	Ya-Di Zhu, Xiao-Qing Guan, Jing Chen, Sheng Peng, Moshe Finel, Ying-Yuan Zhao, Rui-Min Wang, Hui-Chang Bi, Ming Lei, Dan-Dan Wang, Guang-Bo Ge
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Pharmacology
Subjects:	UDP-glucuronosyltransferase 1A1 flavonoids induction peroxisome proliferator-activated receptors neobavaisoflavone
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2020.628314/full

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