Protein condensation diseases: therapeutic opportunities
In this review, the authors define protein condensation diseases as conditions caused by aberrant liquid-like or solid-like states of proteins, and describe opportunities for therapeutic interventions to restore the normal phase behaviour of proteins. The review accompanies the related collection of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32940-7 |
| _version_ | 1798001601904902144 |
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| author | Michele Vendruscolo Monika Fuxreiter |
| author_facet | Michele Vendruscolo Monika Fuxreiter |
| author_sort | Michele Vendruscolo |
| collection | DOAJ |
| description | In this review, the authors define protein condensation diseases as conditions caused by aberrant liquid-like or solid-like states of proteins, and describe opportunities for therapeutic interventions to restore the normal phase behaviour of proteins. The review accompanies the related collection of articles published in Nature Communications focusing on possible therapeutic approaches involving liquid-liquid phase separation. |
| first_indexed | 2024-04-11T11:40:01Z |
| format | Article |
| id | doaj.art-5a1a0361c601474cb9440cce7606f01a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T11:40:01Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5a1a0361c601474cb9440cce7606f01a2022-12-22T04:25:52ZengNature PortfolioNature Communications2041-17232022-09-0113111110.1038/s41467-022-32940-7Protein condensation diseases: therapeutic opportunitiesMichele Vendruscolo0Monika Fuxreiter1Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of CambridgeDepartment of Biomedical Sciences, University of PadovaIn this review, the authors define protein condensation diseases as conditions caused by aberrant liquid-like or solid-like states of proteins, and describe opportunities for therapeutic interventions to restore the normal phase behaviour of proteins. The review accompanies the related collection of articles published in Nature Communications focusing on possible therapeutic approaches involving liquid-liquid phase separation.https://doi.org/10.1038/s41467-022-32940-7 |
| spellingShingle | Michele Vendruscolo Monika Fuxreiter Protein condensation diseases: therapeutic opportunities Nature Communications |
| title | Protein condensation diseases: therapeutic opportunities |
| title_full | Protein condensation diseases: therapeutic opportunities |
| title_fullStr | Protein condensation diseases: therapeutic opportunities |
| title_full_unstemmed | Protein condensation diseases: therapeutic opportunities |
| title_short | Protein condensation diseases: therapeutic opportunities |
| title_sort | protein condensation diseases therapeutic opportunities |
| url | https://doi.org/10.1038/s41467-022-32940-7 |
| work_keys_str_mv | AT michelevendruscolo proteincondensationdiseasestherapeuticopportunities AT monikafuxreiter proteincondensationdiseasestherapeuticopportunities |