Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML

Reciprocal regulation of TWIST1 and OGT determines the decitabine efficacy in MDS/AML

Abstract Chemoresistance poses a significant impediment to effective treatment strategies for myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Our previous study unveiled that oncogene TWIST1 interacted with DNA methyltransferase 3a (DNMT3a) to regulate the decitabine (DAC) resistan...

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Bibliographic Details
Main Authors: Hongjiao Li, Yi Wang, Shuang Feng, Kaijing Chang, Xinwen Yu, Fenfang Yang, Haozhe Huang, Yuanbo Wang, Xiang Li, Feng Guan
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cell Communication and Signaling
Subjects:
TWIST1
OGT
O-GlcNAc
DAC resistance
MDS/AML
Online Access:https://doi.org/10.1186/s12964-023-01278-y

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